Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| carboplatin, 3 dimensional conformal radiation therapy, propranolol, intensity modulated radiation therapy, paclitaxel | ADRB3 | Direct | 1 | ||||||||
| durvalumab, gemcitabine, nab paclitaxel, tremelimumab, propranolol, cisplatin | ADRB3 | Direct | 1 | ||||||||
| propranolol, esophageal variceal ligation | ADRB3 | Direct | 1 | ||||||||
| propranolol, placebo | ADRB3 | Direct | 1 | ||||||||
| carteolol | ADRB3 | Direct | yes | 0 | |||||||
| carteolol hydrochloride | ADRB3 | Direct | yes | 0 | |||||||
| carvedilol | ADRB3 | Direct | yes | 0 | |||||||
| carvedilol phosphate | ADRB3 | Direct | yes | 0 | |||||||
| dilevalol | ADRB3 | Direct | yes | 0 | |||||||
| dilevalol hydrochloride | ADRB3 | Direct | yes | 0 | |||||||
| dipivefrin | ADRB3 | Direct | yes | 0 | |||||||
| dipivefrin hydrochloride | ADRB3 | Direct | yes | 0 | |||||||
| ephedrine | ADRB3 | Direct | yes | 0 | |||||||
| ephedrine hydrochloride | ADRB3 | Direct | yes | 0 | |||||||
| ephedrine sulfate | ADRB3 | Direct | yes | 0 | |||||||
| epinephrine | ADRB3 | Direct | yes | 0 | |||||||
| epinephrine bitartrate | ADRB3 | Direct | yes | 0 | |||||||
| hydroxyamphetamine | ADRB3 | Direct | yes | 0 | |||||||
| hydroxyamphetamine hydrobromide | ADRB3 | Direct | yes | 0 | |||||||
| isoproterenol | ADRB3 | Direct | yes | 0 | |||||||
| isoproterenol hydrochloride | ADRB3 | Direct | yes | 0 | |||||||
| isoproterenol sulfate | ADRB3 | Direct | yes | 0 | |||||||
| labetalol | ADRB3 | Direct | yes | 0 | |||||||
| labetalol hydrochloride | ADRB3 | Direct | yes | 0 | |||||||
| mephentermine | ADRB3 | Direct | yes | 0 | |||||||
| mephentermine sulfate | ADRB3 | Direct | yes | 0 | |||||||
| mirabegron | ADRB3 | Direct | yes | 0 | |||||||
| norepinephrine | ADRB3 | Direct | yes | 0 | |||||||
| norepinephrine bitartrate | ADRB3 | Direct | yes | 0 | |||||||
| vibegron | ADRB3 | Direct | yes | 0 | |||||||
| gabapentin, sulfasalazine, memantine, temozolomide, radiotherapy | NFKB2 | SSL via NFKB2 | 1 | ||||||||
| sulfasalazine | NFKB2 | SSL via NFKB2 | 1 | ||||||||
| ataluren | RPL22 | SSL via RPL22 | yes | 0 |