Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 100 of 1796 matching drugs for BCL2 — including drugs targeting any of its 153 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
docetaxel, thalidomide BCL2 Direct 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BCL2 Direct 4
amg 193, docetaxel, comparator amg 193 test tablet BCL2 Direct 3
bms-986340, bms-936558-01, docetaxel BCL2 Direct 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel BCL2 Direct 2
alvocidib, paclitaxel BCL2 Direct 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan BCL2 Direct 2
bryostatin 1, paclitaxel BCL2 Direct 2
btla inhibitor (js004), toripalimab, paclitaxel, cisplatin BCL2 Direct 2
capecitabine, docetaxel BCL2 Direct 2
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy BCL2 Direct 2
carboplatin, docetaxel BCL2 Direct 2
carboplatin, endoscopic biopsy, external beam radiation therapy, lenvatinib mesylate, paclitaxel, pembrolizumab, resection BCL2 Direct 2
carboplatin, esophagectomy, intensity-modulated radiation therapy, paclitaxel, proton beam radiation therapy, quality-of-life assessment, questionnaire administration, folfox regimen, capox regimen, docetaxel, 5fu BCL2 Direct 2
carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy BCL2 Direct 2
carboplatin, paclitaxel, panitumumab, radiotherapy BCL2 Direct 2
carboplatin, paclitaxel, radiation therapy, telomerase-specific type 5 adenovirus obp-301 BCL2 Direct 2
carboplatin, paclitaxel, three-dimensional conformal radiation therapy BCL2 Direct 2
cetuximab, cisplatin, docetaxel, adjuvant therapy, neoadjuvant therapy BCL2 Direct 2
chemotherapy, cisplatin, paclitaxel, low-let electron therapy, low-let photon therapy BCL2 Direct 2
cisplatin, docetaxel, irinotecan hydrochloride, radiation therapy BCL2 Direct 2
cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy BCL2 Direct 2
cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy BCL2 Direct 2
cisplatin, paclitaxel, surgical procedure, radiation therapy BCL2 Direct 2
cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study BCL2 Direct 2
dkn-01 150 mg, paclitaxel, pembrolizumab, dkn-01 300 mg BCL2 Direct 2
docetaxel, 5-fu, radiotherapy, esophagectomy, dexamethasone BCL2 Direct 2
durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel BCL2 Direct 2
filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy BCL2 Direct 2
filgrastim, paclitaxel, topotecan hydrochloride BCL2 Direct 2
filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy BCL2 Direct 2
gemcitabine hydrochloride, paclitaxel, tipifarnib, radiation therapy BCL2 Direct 2
irinotecan, docetaxel BCL2 Direct 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed BCL2 Direct 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a BCL2 Direct 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine BCL2 Direct 2
onc-392, pembrolizumab, docetaxel BCL2 Direct 2
paclitaxel BCL2 Direct 2
pembrolizumab, paclitaxel BCL2 Direct 2
pembrolizumab, paclitaxel, docetaxel, irinotecan BCL2 Direct 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin BCL2 Direct 2
pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography BCL2 Direct 2
ramucirumab, paclitaxel BCL2 Direct 2
5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) BCL2 Direct 1
5-fluorouracil, docetaxel, oxaliplatin BCL2 Direct 1
5-fluorouracil, leucovorin, oxaliplatin, docetaxel, carboplatin, paclitaxel, neoadjuvant radiation BCL2 Direct 1
5-fluoruracil, cisplatinum, docetaxel BCL2 Direct 1
5-fu, leucovorin, docetaxel, oxaliplatin (flot), trastuzumab, post-operative treatment trastuzumab mono therapy BCL2 Direct 1
afatinib, docetaxel, radiation therapy BCL2 Direct 1
afuresertib, nab paclitaxel, docetaxel, sintilimab BCL2 Direct 1
agent-797, botensilimab, balstilimab, ramucirumab, paclitaxel BCL2 Direct 1
ak109, paclitaxel, paclitaxel, ak104 BCL2 Direct 1
aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation BCL2 Direct 1
alvocidib, docetaxel BCL2 Direct 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel BCL2 Direct 1
anetumab ravtansine, bevacizumab, paclitaxel BCL2 Direct 1
atezolizumab, 5-fluorouracil, calciumfolinat, oxaliplatin, docetaxel BCL2 Direct 1
atezolizumab, biospecimen collection, capecitabine, computed tomography, docetaxel, echocardiography, fluorouracil, leucovorin calcium, lymphadenectomy, magnetic resonance imaging, oxaliplatin, positron emission tomography, surgical procedure BCL2 Direct 1
atezolizumab, tiragolumab, paclitaxel, cisplatin, atezolizumab matching placebo, tiragolumab matching placebo BCL2 Direct 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) BCL2 Direct 1
azd6244, dacarbazine, erlotinib, docetaxel, temsirolimus BCL2 Direct 1
bbi608, paclitaxel, placebo BCL2 Direct 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil BCL2 Direct 1
bevacizumab, docetaxel, oxaliplatin BCL2 Direct 1
biological ni-1801, ni-1801 in combination with anti-pd1 (pembrolizumab), ni-1801 in combination with paclitaxel, paclitaxel BCL2 Direct 1
biospecimen collection, computed tomography, endoscopic ultrasound, esophagogastroduodenoscopy, fluorouracil, hypofractionated radiation therapy, leucovorin calcium, oxaliplatin, positron emission tomography, survey administration, docetaxel BCL2 Direct 1
biospecimen collection, computed tomography, magnetic resonance imaging, nivolumab, paclitaxel, questionnaire administration, ramucirumab BCL2 Direct 1
bl-b01d1, irinotecan, paclitaxel, docetaxel BCL2 Direct 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan BCL2 Direct 1
bortezomib, carboplatin, paclitaxel BCL2 Direct 1
cadonilimab, ak117, oxaliplatin, tegafur-gimeracil-oteracil potassium, docetaxel, 5-fluorouracil BCL2 Direct 1
cadonilimab, pulocimab, paclitaxel, placebo BCL2 Direct 1
cadonilimab, radiotherapy, carboplatin, paclitaxel BCL2 Direct 1
camrelizumab, docetaxel, irinotecan BCL2 Direct 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib BCL2 Direct 1
camrelizumab, paclitaxel, cisplatin BCL2 Direct 1
camrelizumab, paclitaxel, cisplatin, radiotherapy BCL2 Direct 1
capecitabine, carboplatin, docetaxel, fluorouracil, hafnium oxide-containing nanoparticles nbtxr3, intensity-modulated radiation therapy, leucovorin, oxaliplatin, paclitaxel BCL2 Direct 1
capecitabine, cisplatin, docetaxel, epirubicin hydrochloride, gemcitabine hydrochloride BCL2 Direct 1
capecitabine, docetaxel, fluorouracil, leucovorin, oxaliplatin, radiation therapy, surgical procedure BCL2 Direct 1
capecitabine, docetaxel, fluorouracil, oxaliplatin, radiation therapy, therapeutic conventional surgery BCL2 Direct 1
carboplatin, 3 dimensional conformal radiation therapy, propranolol, intensity modulated radiation therapy, paclitaxel BCL2 Direct 1
carboplatin, cisplatin, docetaxel, etoposide, pembrolizumab BCL2 Direct 1
carboplatin, computed tomography, fluorouracil, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel, pembrolizumab, positron emission tomography, radiation therapy, therapeutic conventional surgery BCL2 Direct 1
carboplatin, ganetespib, paclitaxel, radiation therapy BCL2 Direct 1
carboplatin, laboratory biomarker analysis, paclitaxel, quality-of-life assessment, radiation therapy, therapeutic conventional surgery, trastuzumab BCL2 Direct 1
carboplatin, laboratory biomarker analysis, paclitaxel, wild-type reovirus BCL2 Direct 1
carboplatin, paclitaxel, azd1775 BCL2 Direct 1
carboplatin, paclitaxel, vadimezan BCL2 Direct 1
carboxyamidotriazole, paclitaxel BCL2 Direct 1
catumaxomab, fluorouracil, leucovorin, oxaliplatin, docetaxel, fluorouracil, leucovorin, oxaliplatin, docetaxel BCL2 Direct 1
cetuximab (erbitux), paclitaxel, cisplatin, radiation BCL2 Direct 1
cetuximab, cisplatin, paclitaxel, radiation therapy BCL2 Direct 1
cisplatin, docetaxel, floxuridine, fluorouracil, leucovorin calcium, conventional surgery BCL2 Direct 1
cisplatin, docetaxel, fluorouracil, radiation therapy BCL2 Direct 1
cisplatin, docetaxel, gemcitabine hydrochloride BCL2 Direct 1
cisplatin, docetaxel, gemcitabine hydrochloride, irinotecan hydrochloride BCL2 Direct 1
cisplatin, irinotecan hydrochloride, paclitaxel, conventional surgery, radiation therapy BCL2 Direct 1
cisplatin, oxaliplatin, fluorouracil (5-fu), capecitabine, paclitaxel, tislelizumab, placebo BCL2 Direct 1
cisplatin, paclitaxel, 5-fu BCL2 Direct 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.