Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells | CHRNB4 | Direct | 2 | ||||||||
| ethanol, enoxaparin | CHRNB4 | Direct | 1 | ||||||||
| mecamylamine | CHRNB4 | Direct | yes | 0 | |||||||
| mecamylamine hydrochloride | CHRNB4 | Direct | yes | 0 | |||||||
| pentolinium | CHRNB4 | Direct | yes | 0 | |||||||
| pentolinium tartrate | CHRNB4 | Direct | yes | 0 | |||||||
| trimethaphan | CHRNB4 | Direct | yes | 0 | |||||||
| trimethaphan camsylate | CHRNB4 | Direct | yes | 0 | |||||||
| biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan | ATR | SSL via ATR | 1 | ||||||||
| ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin | TP53 | SSL via TP53 | 1 | ||||||||
| ceralasertib, olaparib, durvalumab | ATR | SSL via ATR | 1 | ||||||||
| cisplatin, carboplatin, etoposide, durvalumab, ceralasertib | ATR | SSL via ATR | 1 |