Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| filgrastim, paclitaxel, topotecan hydrochloride | CSF3R | Direct | 2 | ||||||||
| aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| anti-thymocyte globulin, filgrastim, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy | CSF3R | Direct | 1 | ||||||||
| anti-thymocyte globulin, filgrastim, busulfan, cyclophosphamide, methylprednisolone, umbilical cord blood transplantation, radiation therapy | CSF3R | Direct | 1 | ||||||||
| cetuximab, filgrastim, fluorouracil, irinotecan hydrochloride, leucovorin calcium | CSF3R | Direct | 1 | ||||||||
| epoetin alfa, filgrastim, cisplatin, fluorouracil, gemcitabine hydrochloride, adjuvant therapy, conventional surgery, neoadjuvant therapy, radiation therapy | CSF3R | Direct | 1 | ||||||||
| filgrastim, amifostine trihydrate, cisplatin, etoposide, paclitaxel, topotecan hydrochloride, radiation therapy | CSF3R | Direct | 1 | ||||||||
| filgrastim, busulfan, cyclophosphamide, etoposide, melphalan, autologous-autologous tandem hematopoietic stem cell transplantation, radiation therapy | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, cisplatin, cyclophosphamide, etoposide, thiotepa, vincristine sulfate, conventional surgery, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, cyclophosphamide, etoposide, autologous bone marrow transplantation, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, cyclophosphamide, paclitaxel, topotecan hydrochloride, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, bone marrow ablation with stem cell support, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, ifosfamide, in vitro-treated peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, isotretinoin, thiotepa, autologous bone marrow transplantation, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, paclitaxel, topotecan hydrochloride, radiation therapy | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, paclitaxel, topotecan hydrochloride | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, temozolomide, thiotepa, autologous bone marrow transplantation, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, carboplatin, thiotepa, autologous bone marrow transplantation, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy | CSF3R | Direct | 1 | ||||||||
| filgrastim, docetaxel, gemcitabine hydrochloride | CSF3R | Direct | 1 | ||||||||
| filgrastim, exatecan mesylate | CSF3R | Direct | 1 | ||||||||
| filgrastim, gemcitabine hydrochloride, vinorelbine tartrate | CSF3R | Direct | 1 | ||||||||
| filgrastim, gene therapy, lomustine, procarbazine hydrochloride, vincristine sulfate, in vitro-treated peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | CSF3R | Direct | 1 | ||||||||
| filgrastim, recombinant interferon alfa, fluorouracil, hydroxyurea | CSF3R | Direct | 1 | ||||||||
| filgrastim, sargramostim, cyclophosphamide, thiotepa, autologous bone marrow transplantation, bone marrow ablation with stem cell support, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| filgrastim, temozolomide, peripheral blood stem cell transplantation | CSF3R | Direct | 1 | ||||||||
| fludarabine phosphate, cyclophosphamide, rituxan (rituximab), filgrastim, methylprednisolone, immunologic technique, laboratory biomarker analysis, autologous hematopoietic stem cell transplantation, diphenhydramine, mesna | CSF3R | Direct | 1 | ||||||||
| gemcitabine, ribociclib, sonidegib, trametinib, filgrastim | CSF3R | Direct | 1 | ||||||||
| laboratory biomarker analysis, pegfilgrastim, pharmacological study, tivantinib, topotecan hydrochloride | CSF3R | Direct | 1 | ||||||||
| ly2523355, pegfilgrastim | CSF3R | Direct | 1 | ||||||||
| o6-benzylguanine, temozolomide, filgrastim, pharmacological study, laboratory biomarker analysis | CSF3R | Direct | 1 | ||||||||
| p140k-mgmt, o6-benzylguanine, photon based radiotherapy, temozolomide, filgrastim, carmustine | CSF3R | Direct | 1 | ||||||||
| filgrastim | CSF3R | Direct | yes | 0 | |||||||
| pegfilgrastim | CSF3R | Direct | yes | 0 | |||||||
| unnamed compound | CSF3R | Direct | yes | 0 | |||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| adriamycin, cyclophosphamide, vindesine, valproic acid | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| arsenic trioxide | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| arsenic trioxide, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| atorvastatin, temozolomide, radiotherapy | HMGCR | SSL via HMGCR | 1 | ||||||||
| irinotecan, cisplatin, simvastatin | HMGCR | SSL via HMGCR | 1 | ||||||||
| medical cannabis | HMGCR | SSL via HMGCR | 1 | ||||||||
| nabiximols, temozolomide, nabiximols-matched placebo | HMGCR | SSL via HMGCR | 1 | ||||||||
| rosuvastatin | HMGCR | SSL via HMGCR | yes | 1 | |||||||
| sorafenib tosylate, valproic acid, sildenafil citrate | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| valproic acid | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| valproic acid, bevacizumab, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| atorvastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| atorvastatin calcium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| cerivastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| cerivastatin sodium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| fluvastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| fluvastatin sodium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| lemborexant | HCRTR1 | SSL via HCRTR1 | yes | 0 | |||||||
| lovastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| midostaurin | PRKCD | SSL via PRKCD | yes | 0 | |||||||
| pitavastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| pitavastatin calcium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| pitavastatin magnesium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| pitavastatin sodium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| pravastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| pravastatin sodium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| rosuvastatin calcium | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| simvastatin | HMGCR | SSL via HMGCR | yes | 0 | |||||||
| suvorexant | HCRTR1 | SSL via HCRTR1 | yes | 0 |