Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 226 matching drugs for DBH — including drugs targeting any of its 22 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine DBH Direct 1
chemotherapy, disulfiram, gemcitabine hydrochloride, laboratory biomarker analysis DBH Direct 1
disulfiram, copper gluconate, surgery, radiation, temozolomide DBH Direct 1
disulfiram, copper, alkylating agents DBH Direct 1
oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, ascorbic acid DBH Direct 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin DBH Direct 1
temozolomide, disulfiram, copper gluconate DBH Direct 1
temozolomide, radiation therapy, ascorbic acid DBH Direct 1
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib ALK SSL via ALK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib FGFR3 SSL via FGFR3 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CD SSL via PIK3CD 3
crizotinib ALK SSL via ALK yes 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan FGFR3 SSL via FGFR3 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan TOP1 SSL via TOP1 3
lurbinectedin, irinotecan TOP1 SSL via TOP1 3
pembrolizumab, belzutifan, lenvatinib FGFR3 SSL via FGFR3 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel ALK SSL via ALK 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel FGFR3 SSL via FGFR3 2
alectinib, stereotactic radiosurgery ALK SSL via ALK 2
apatinib, irinotecan TOP1 SSL via TOP1 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan TOP1 SSL via TOP1 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine TOP1 SSL via TOP1 2
bbi-355, erlotinib, futibatinib FGFR3 SSL via FGFR3 2
bryostatin 1, paclitaxel PRKCA SSL via PRKCA 2
cetuximab, cisplatin, irinotecan, radiation therapy, surgery TOP1 SSL via TOP1 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib ALK SSL via ALK 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a FGFR3 SSL via FGFR3 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide TOP1 SSL via TOP1 2
irinotecan, capecitabine TOP1 SSL via TOP1 2
irinotecan, docetaxel TOP1 SSL via TOP1 2
lenvatinib, pembrolizumab FGFR3 SSL via FGFR3 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate FGFR3 SSL via FGFR3 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab TOP1 SSL via TOP1 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a FGFR3 SSL via FGFR3 2
nintedanib FGFR3 SSL via FGFR3 yes 2
nintedanib, pembrolizumab FGFR3 SSL via FGFR3 2
pazopanib FGFR3 SSL via FGFR3 yes 2
pembrolizumab, lenvatinib FGFR3 SSL via FGFR3 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu FGFR3 SSL via FGFR3 2
pembrolizumab, paclitaxel, docetaxel, irinotecan TOP1 SSL via TOP1 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin FGFR3 SSL via FGFR3 2
quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery FGFR3 SSL via FGFR3 2
rubitecan TOP1 SSL via TOP1 2
sacituzumab govitecan TOP1 SSL via TOP1 yes 2
topotecan TOP1 SSL via TOP1 yes 2
trastuzumab deruxtecan TOP1 SSL via TOP1 yes 2
5 fluorouracil, leucovorin, irinotecan, oxaliplatin TOP1 SSL via TOP1 1
9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan TOP1 SSL via TOP1 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf TOP1 SSL via TOP1 1
afatinib, irinotecan TOP1 SSL via TOP1 1
aldoxorubicin, topotecan TOP1 SSL via TOP1 1
amrubicin, topotecan TOP1 SSL via TOP1 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel TOP1 SSL via TOP1 1
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib ALK SSL via ALK 1
at-101, topotecan TOP1 SSL via TOP1 1
avastin, temozolomide, irinotecan TOP1 SSL via TOP1 1
avastin, temozolomide, radiation therapy (xrt), irinotecan TOP1 SSL via TOP1 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) TOP1 SSL via TOP1 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine TOP1 SSL via TOP1 1
azenosertib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, multigated acquisition scan, trastuzumab deruxtecan TOP1 SSL via TOP1 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 TOP1 SSL via TOP1 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil TOP1 SSL via TOP1 1
berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging TOP1 SSL via TOP1 1
berzosertib, sacituzumab govitecan TOP1 SSL via TOP1 1
bevacizumab [avastin], irinotecan, temozolomide TOP1 SSL via TOP1 1
bevacizumab, irinotecan TOP1 SSL via TOP1 1
bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging TOP1 SSL via TOP1 1
bevacizumab, temozolomide, radiation therapy (xrt), topotecan TOP1 SSL via TOP1 1
bi 764532, topotecan, single agent chemotherapy TOP1 SSL via TOP1 1
biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan TOP1 SSL via TOP1 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CD SSL via PIK3CD 1
biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin TOP1 SSL via TOP1 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging FGFR3 SSL via FGFR3 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CD SSL via PIK3CD 1
biopsy, biospecimen collection, crizotinib, radiologic examination ALK SSL via ALK 1
biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab TOP1 SSL via TOP1 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography FGFR3 SSL via FGFR3 1
bl-b01d1, irinotecan, paclitaxel, docetaxel TOP1 SSL via TOP1 1
bl-b01d1, topotecan TOP1 SSL via TOP1 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan TOP1 SSL via TOP1 1
bortezomib, irinotecan TOP1 SSL via TOP1 1
byl719, poziotinib, nintedanib, abemaciclib, durvalumab,tremelimumab FGFR3 SSL via FGFR3 1
camrelizumab, docetaxel, irinotecan TOP1 SSL via TOP1 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib TOP1 SSL via TOP1 1
capecitabine, oxaliplatin, irinotecan TOP1 SSL via TOP1 1
carboplatin, irinotecan TOP1 SSL via TOP1 1
carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study TOP1 SSL via TOP1 1
ceritinib, cisplatin, gemcitabine hydrochloride, laboratory biomarker analysis, paclitaxel albumin-stabilized nanoparticle formulation, pharmacological study ALK SSL via ALK 1
cetuximab, bevacizumab, irinotecan TOP1 SSL via TOP1 1
cetuximab, irinotecan, oxaliplatin, uft TOP1 SSL via TOP1 1
cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy TOP1 SSL via TOP1 1
cisplatin, gleevec™, irinotecan TOP1 SSL via TOP1 1
cisplatin, irinotecan, capecitabine TOP1 SSL via TOP1 1
cytoreductive surgery, perifosine, temsirolimus PRKCA SSL via PRKCA 1
digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin TOP1 SSL via TOP1 1
doxorubicin, cisplatin, 5-fluorouracil TOP1 SSL via TOP1 1
durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf TOP1 SSL via TOP1 1
edotecarin, temozolomide, carmustine (bcnu), lomustine (ccnu) TOP1 SSL via TOP1 1
erdafitinib FGFR3 SSL via FGFR3 yes 1
fluorouracil (5-fu), capecitabine, durvalumab, oxaliplatin, trastuzumab, trastuzumab deruxtecan, cisplatin, pembrolizumab, volrustomig, rilvegostomig TOP1 SSL via TOP1 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.