Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 552 matching drugs for DHFR — including drugs targeting any of its 20 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel DHFR Direct 2
avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 DHFR Direct 2
biospecimen collection, computed tomography, pemetrexed DHFR Direct 2
cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab DHFR Direct 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide DHFR Direct 2
ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib DHFR Direct 2
laboratory biomarker analysis, oxaliplatin, pralatrexate DHFR Direct 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab DHFR Direct 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed DHFR Direct 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a DHFR Direct 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine DHFR Direct 2
pemetrexed, bevacizumab DHFR Direct 2
pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography DHFR Direct 2
sar444881, pembrolizumab, cetuximab, carboplatin, pemetrexed DHFR Direct 2
tislelizumab, pemetrexed DHFR Direct 2
whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy DHFR Direct 2
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel DHFR Direct 1
can04, cisplatin, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed DHFR Direct 1
certolizumab, cisplatin, pemetrexed DHFR Direct 1
cisplatin, methotrexate, vinorelbine ditartrate, adjuvant therapy, conventional surgery, neoadjuvant therapy, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy DHFR Direct 1
cryoablation, pembrolizumab, pemetrexed, carboplatin DHFR Direct 1
epacadostat, pembrolizumab, oxaliplatin, leucovorin, 5-fluorouracil, gemcitabine, nab-paclitaxel, carboplatin, paclitaxel, pemetrexed, cyclophosphamide, carboplatin, cisplatin, 5-fluorouracil, investigator's choice of platinum agent DHFR Direct 1
erlotinib, pemetrexed, cisplatin, erlotinib DHFR Direct 1
farletuzumab, placebo, carboplatin, paclitaxel, pemetrexed, cisplatin DHFR Direct 1
gen1042, pembrolizumab, cisplatin, carboplatin, 5-fu, gemcitabine, nab paclitaxel, pemetrexed, paclitaxel DHFR Direct 1
leucovorin calcium, methotrexate DHFR Direct 1
methotrexate, pharmacological study DHFR Direct 1
mopp regimen, leucovorin calcium, mechlorethamine hydrochloride, methotrexate, prednisone, procarbazine hydrochloride, vincristine sulfate, conventional surgery DHFR Direct 1
paclitaxel, pemetrexed, 5fluorouracil, carboplatin, pembrolizumab DHFR Direct 1
pemetrexed DHFR Direct yes 1
pemetrexed, cetuximab, cisplatin, folic acid, vitamin b12 DHFR Direct 1
pemetrexed, cisplatin DHFR Direct 1
pf-07934040, gemcitabine, nab-paclitaxel, cetuximab, fluorouracil, oxaliplatin, leucovorin, bevacizumab, pembrolizumab, pemetrexed, cisplatin, paclitaxel, carboplatin DHFR Direct 1
pf-07985045, gemcitabine, nab-paclitaxel, cetuximab, fluorouracil, oxaliplatin, leucovorin, bevacizumab, pembrolizumab, sasanlimab, pemetrexed, cisplatin, paclitaxel, carboplatin, pf-07284892 DHFR Direct 1
tacrolimus, methotrexate, sirolimus DHFR Direct 1
treosulfan, fludarabine phosphate, tacrolimus, methotrexate, lapine t-lymphocyte immune globulin, peripheral blood stem cell transplantation, allogeneic bone marrow transplantation, quality-of-life assessment, echocardiography, multigated acquisition scan, bone marrow biopsy, bone marrow aspiration, biospecimen collection, x-ray imaging, computed tomography DHFR Direct 1
methotrexate DHFR Direct yes 0
methotrexate sodium DHFR Direct yes 0
pemetrexed disodium DHFR Direct yes 0
pralatrexate DHFR Direct yes 0
unnamed compound DHFR Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
afatinib EGFR SSL via EGFR yes 2
dacomitinib EGFR SSL via EGFR yes 2
erlotinib EGFR SSL via EGFR yes 2
gefitinib EGFR SSL via EGFR yes 2
sotorasib KRAS SSL via KRAS yes 2
lazertinib and amivantamab EGFR SSL via EGFR 1
osimertinib EGFR SSL via EGFR yes 1
ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine TYMS SSL via TYMS 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib WEE1 SSL via WEE1 3
capecitabine, cisplatin TYMS SSL via TYMS 3
gemcitabine TYMS SSL via TYMS 3
srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab TYMS SSL via TYMS 3
5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin TYMS SSL via TYMS 2
ab598, zimberelimab, fluorouracil, leucovorin, oxaliplatin TYMS SSL via TYMS 2
adavosertib, radiation therapy WEE1 SSL via WEE1 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel TYMS SSL via TYMS 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan TYMS SSL via TYMS 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine TYMS SSL via TYMS 2
avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 TYMS SSL via TYMS 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment TYMS SSL via TYMS 2
bevacizumab, oxaliplatin, leucovorin calcium, fluorouracil, therapeutic conventional surgery, laboratory biomarker analysis TYMS SSL via TYMS 2
biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging TYMS SSL via TYMS 2
biospecimen collection, computed tomography, pemetrexed TYMS SSL via TYMS 2
capecitabine TYMS SSL via TYMS yes 2
capecitabine, carboplatin, epirubicin hydrochloride TYMS SSL via TYMS 2
capecitabine, docetaxel TYMS SSL via TYMS 2
capecitabine, irinotecan hydrochloride TYMS SSL via TYMS 2
capecitabine, oxaliplatin TYMS SSL via TYMS 2
capecitabine, oxaliplatin, gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction, adjuvant therapy, biopsy, conventional surgery, neoadjuvant therapy, quality-of-life assessment, radiation therapy TYMS SSL via TYMS 2
capecitabine, temozolomide TYMS SSL via TYMS 2
carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy TYMS SSL via TYMS 2
cetuximab, cisplatin, fluorouracil, conventional surgery TYMS SSL via TYMS 2
chemotherapy, cisplatin, fluorouracil, low-let electron therapy, low-let photon therapy TYMS SSL via TYMS 2
cisplatin, fluorouracil, conventional surgery, neoadjuvant therapy, radiation therapy TYMS SSL via TYMS 2
cisplatin, fluorouracil, iressa, conventional surgery, radiation therapy TYMS SSL via TYMS 2
cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy TYMS SSL via TYMS 2
cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy TYMS SSL via TYMS 2
cisplatin, fluorouracil, surgical procedure, radiation therapy TYMS SSL via TYMS 2
cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab TYMS SSL via TYMS 2
durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel TYMS SSL via TYMS 2
erlotinib hydrochloride, oxaliplatin, fluorouracil, radiation therapy, conventional surgery, immunohistochemistry staining method, positron emission tomography, computed tomography, laboratory biomarker analysis, gene expression analysis, fludeoxyglucose f 18 TYMS SSL via TYMS 2
filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy TYMS SSL via TYMS 2
filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy TYMS SSL via TYMS 2
fluorouracil, gemcitabine hydrochloride, leucovorin calcium TYMS SSL via TYMS 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, pharmacogenomic studies, pharmacological study TYMS SSL via TYMS 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study HDAC2 SSL via HDAC2 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study TYMS SSL via TYMS 2
fluorouracil, oxaliplatin, conventional surgery, radiation therapy TYMS SSL via TYMS 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide TYMS SSL via TYMS 2
ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib TYMS SSL via TYMS 2
irinotecan, capecitabine TYMS SSL via TYMS 2
laboratory biomarker analysis, oxaliplatin, pralatrexate TYMS SSL via TYMS 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab TYMS SSL via TYMS 2
m6620, cisplatin, capecitabine, radiotherapy TYMS SSL via TYMS 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed TYMS SSL via TYMS 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a TYMS SSL via TYMS 2
nab-paclitaxel, gemcitabine TYMS SSL via TYMS 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine TYMS SSL via TYMS 2
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.