Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 280 matching drugs for FDPS — including drugs targeting any of its 57 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
alendronate, etidronate, ibandronate, risedronate, raloxifene FDPS Direct 2
aldesleukin, therapeutic autologous lymphocytes, zoledronic acid FDPS Direct 1
capecitabine, fluorouracil, laboratory biomarker analysis, pharmacological study, stereotactic body radiation therapy, zoledronic acid FDPS Direct 1
imab362, zoledronic acid, interleukin-2 (1 million iu), interleukin-2 (3 million iu) FDPS Direct 1
alendronate sodium FDPS Direct yes 0
alendronic acid FDPS Direct yes 0
ibandronate sodium FDPS Direct yes 0
pamidronate disodium FDPS Direct yes 0
pamidronic acid FDPS Direct yes 0
risedronate sodium FDPS Direct yes 0
risedronic acid FDPS Direct yes 0
zoledronic acid FDPS Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
sotorasib KRAS SSL via KRAS yes 2
ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 3
gemcitabine RRM1 SSL via RRM1 yes 3
srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab RRM1 SSL via RRM1 3
5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin RRM1 SSL via RRM1 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine RRM1 SSL via RRM1 2
cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab RRM1 SSL via RRM1 2
ksq-001ex, interleukin-2, cyclophosphamide, fludarabine RRM1 SSL via RRM1 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab RRM1 SSL via RRM1 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed RRM1 SSL via RRM1 2
nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 2
oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu RRM1 SSL via RRM1 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin RRM1 SSL via RRM1 2
selinexor XPO1 SSL via XPO1 yes 2
sy-5609, fulvestrant, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 2
9-ing-41, retifanlimab, gemcitabine, abraxane RRM1 SSL via RRM1 1
abemaciclib, ly3023414, gemcitabine, capecitabine RRM1 SSL via RRM1 1
abraxane (nab-paclitaxel), gemcitabine RRM1 SSL via RRM1 1
adct-601, gemcitabine RRM1 SSL via RRM1 1
ag-013736, gemcitabine, gemcitabine, placebo RRM1 SSL via RRM1 1
agen1423, botensilimab, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
ags-1c4d4, gemcitabine RRM1 SSL via RRM1 1
ak104, ak104, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 1
albumin-bound paclitaxel (abi-007), gemcitabine RRM1 SSL via RRM1 1
aldesleukin, biopsy, biospecimen collection, computed tomography, cyclophosphamide, excisional biopsy, fludarabine, magnetic resonance imaging, standard treatment, therapeutic tumor infiltrating lymphocytes RRM1 SSL via RRM1 1
alisertib, gemcitabine RRM1 SSL via RRM1 1
amg 193, gemcitabine, nab-paclitaxel, modified folfirinox RRM1 SSL via RRM1 1
amg 479, placebo, amg 479, gemcitabine RRM1 SSL via RRM1 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel RRM1 SSL via RRM1 1
apg-1387 for injection, gemcitabine, nab paclitaxel RRM1 SSL via RRM1 1
apx005m, nivolumab, nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 1
arq 197, gemcitabine RRM1 SSL via RRM1 1
ascorbate, nab paclitaxel, gemcitabine RRM1 SSL via RRM1 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine RRM1 SSL via RRM1 1
atra, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
autologous mesothelin-specific tcr-t cells, cyclophosphamide, fludarabine, bendamustine RRM1 SSL via RRM1 1
avastin (bevacizumab), gemcitabine, radiation therapy RRM1 SSL via RRM1 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab RRM1 SSL via RRM1 1
azd0171, durvalumab, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine RRM1 SSL via RRM1 1
azd1775, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 RRM1 SSL via RRM1 1
bendamustine, biopsy, biospecimen collection, computed tomography, cyclophosphamide, echocardiography, fludarabine, leukapheresis, magnetic resonance imaging, multigated acquisition scan, positron emission tomography, t-cell receptor-engineered t-cells RRM1 SSL via RRM1 1
bethanechol, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
bevacizumab, erlotinib, gemcitabine RRM1 SSL via RRM1 1
bi 765883, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
biopsy, biospecimen collection, cisplatin, computed tomography, gemcitabine, gemcitabine hydrochloride, magnetic resonance imaging, veliparib RRM1 SSL via RRM1 1
biopsy, biospecimen collection, cisplatin, computed tomography, gemcitabine, magnetic resonance imaging, nab-paclitaxel, pancreatic surgical procedure RRM1 SSL via RRM1 1
biopsy, biospecimen collection, diagnostic imaging, elimusertib, gemcitabine RRM1 SSL via RRM1 1
biopsy, magnetic resonance imaging, radiation therapy, selinexor XPO1 SSL via XPO1 1
biospecimen collection, cholestyramine, computed tomography, diagnostic imaging, gemcitabine, leflunomide, magnetic resonance imaging RRM1 SSL via RRM1 1
biospecimen collection, magnetic resonance imaging, selinexor, temozolomide XPO1 SSL via XPO1 1
bms-813160, nivolumab, gemcitabine, nab-paclitaxel, biopsy, peripheral blood RRM1 SSL via RRM1 1
botensilimab, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
busulfan, anti-thymocyte globulin, fludarabine, cyclosporine, mycophenolate mofetil RRM1 SSL via RRM1 1
cadonilimab, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
can04, cisplatin, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed RRM1 SSL via RRM1 1
canakinumab injection; spartalizumab, nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 1
canakinumab, tislelizumab, nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 1
capecitabine, cisplatin, epirubicin, gemcitabine RRM1 SSL via RRM1 1
cend-1, gemcitabine, nab paclitaxel RRM1 SSL via RRM1 1
cend-1, nab-paclitaxel, gemcitabine RRM1 SSL via RRM1 1
cetuximab, capecitabine, oxaliplatin, conventional surgery, radiation therapy, gemcitabine RRM1 SSL via RRM1 1
chemotherapy, cladribine, radiation therapy RRM1 SSL via RRM1 1
chemotherapy, hydroxyurea, pentoxifylline, radiation therapy RRM1 SSL via RRM1 1
cisplatin, capecitabine, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy RRM1 SSL via RRM1 1
cisplatin, gemcitabine, anetumab ravtansine (bay94-9343) RRM1 SSL via RRM1 1
co-1.01, gemcitabine RRM1 SSL via RRM1 1
cpi-613® (dose level -1.0 250 mg/m^2), cpi-613® (dose level 1.0 500 mg/m^2), cpi-613® (dose level 2.0 1,000 mg/m^2), cpi-613® (dose level 3.0 1,500 mg/m^2), cpi-613® maximum tolerated dose (mtd), gemcitabine, intensity-modulated radiation therapy RRM1 SSL via RRM1 1
cyberknife based stereotactic radiotherapy, gemcitabine, fludeoxyglucose (18f) (fdg) RRM1 SSL via RRM1 1
cyclophosphamide, fludarabine, aldesleukin, anti-hcd70 car transduced pbl RRM1 SSL via RRM1 1
cyclophosphamide, fludarabine, mutant kras g12v-specific tcr transduced autologous t cells, anti-pd-1 monoclonal antibody RRM1 SSL via RRM1 1
decitabine, gemcitabine RRM1 SSL via RRM1 1
demcizumab, abraxane®, gemcitabine, placebo RRM1 SSL via RRM1 1
docetaxel, gemcitabine RRM1 SSL via RRM1 1
durvalumab, gemcitabine, nab paclitaxel, tremelimumab, propranolol, cisplatin RRM1 SSL via RRM1 1
durvalumab, gemcitabine, nab-paclitaxel, oleclumab RRM1 SSL via RRM1 1
e7 tcr cells, aldesleukin, fludarabine, cyclophosphamide RRM1 SSL via RRM1 1
electroporation, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
endotag-1, gemcitabine RRM1 SSL via RRM1 1
epacadostat, pembrolizumab, oxaliplatin, leucovorin, 5-fluorouracil, gemcitabine, nab-paclitaxel, carboplatin, paclitaxel, pemetrexed, cyclophosphamide, carboplatin, cisplatin, 5-fluorouracil, investigator's choice of platinum agent RRM1 SSL via RRM1 1
epidermal growth factor receptor(egfrv)iii chimeric antigen receptor (car) transduced pbl, aldesleukin, fludarabine, cyclophosphamide RRM1 SSL via RRM1 1
erlotinib, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
ery001, gemcitabine, 5-fluoro-uracil/oxaliplatin/leucovorin (folfox) RRM1 SSL via RRM1 1
fecal microbiota transplantation, peg3350, gemcitabine, nab-paclitaxel RRM1 SSL via RRM1 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.