Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 89 of 89 matching drugs for FKBP1A — including drugs targeting any of its 85 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
intestinal, multivisceral or modified multivisceral transplantation, alemtuzumab, tacrolimus, sirolimus FKBP1A Direct 1
mycophenolate mofetil, tacrolimus, post-transplant cyclophosphamide, total body irradiation, hematopoietic cell transplant, jsp191, cyclophosphamide, fludarabine FKBP1A Direct 1
pacritinib, sirolimus, tacrolimus, allogenic hematopoietic cell transplant (allohct) FKBP1A Direct 1
tacrolimus modified release (mr), tacrolimus FKBP1A Direct 1
tacrolimus, methotrexate, sirolimus FKBP1A Direct 1
tacrolimus, tacrolimus immediate release FKBP1A Direct 1
treosulfan, fludarabine phosphate, tacrolimus, methotrexate, lapine t-lymphocyte immune globulin, peripheral blood stem cell transplantation, allogeneic bone marrow transplantation, quality-of-life assessment, echocardiography, multigated acquisition scan, bone marrow biopsy, bone marrow aspiration, biospecimen collection, x-ray imaging, computed tomography FKBP1A Direct 1
everolimus FKBP1A Direct yes 0
pimecrolimus FKBP1A Direct yes 0
rapamycin FKBP1A Direct yes 0
tacrolimus FKBP1A Direct yes 0
temsirolimus FKBP1A Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
sotorasib KRAS SSL via KRAS yes 2
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib MAP2K1 SSL via MAP2K1 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib YES1 SSL via YES1 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel MAP2K1 SSL via MAP2K1 2
binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib MAP2K1 SSL via MAP2K1 2
cft1946, trametinib, cetuximab MAP2K1 SSL via MAP2K1 2
cobimetinib, mehd7945a MAP2K1 SSL via MAP2K1 2
jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib MAP2K1 SSL via MAP2K1 2
mirdametinib, bgb-3245 MAP2K1 SSL via MAP2K1 2
nivolumab, ipilimumab, cobimetinib MAP2K1 SSL via MAP2K1 2
selumetinib, medi4736, tremelimumab MAP2K1 SSL via MAP2K1 2
5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) MAP2K1 SSL via MAP2K1 1
afatinib, dasatinib, palbociclib, everolimus, olaparib YES1 SSL via YES1 1
akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib MAP2K1 SSL via MAP2K1 1
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment YES1 SSL via YES1 1
bevacizumab, dasatinib, placebo YES1 SSL via YES1 1
binimetinib MAP2K1 SSL via MAP2K1 yes 1
binimetinib, hydroxychloroquine MAP2K1 SSL via MAP2K1 1
biopsy, calaspargase pegol-mknl, cobimetinib MAP2K1 SSL via MAP2K1 1
bosutinib MAP2K1 SSL via MAP2K1 1
cobimetinib, hydroxychloroquine, atezolizumab MAP2K1 SSL via MAP2K1 1
cobimetinib, olaparib, onvansertib, azenosertib, saruparib, tremelimumab MAP2K1 SSL via MAP2K1 1
dabrafenib, trametinib MAP2K1 SSL via MAP2K1 1
dabrafenib, trametinib, carboplatin, vincristine MAP2K1 SSL via MAP2K1 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride YES1 SSL via YES1 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method YES1 SSL via YES1 1
dasatinib, laboratory biomarker analysis, physiologic testing YES1 SSL via YES1 1
dasatinib, mfolfox6 YES1 SSL via YES1 1
dasatinib, pharmacological study YES1 SSL via YES1 1
dasatinib, temozolomide, placebo, radiation therapy YES1 SSL via YES1 1
disulfiram, copper, alkylating agents CALR SSL via CALR 1
disulfiram, copper, alkylating agents HSPD1 SSL via HSPD1 1
disulfiram, copper, alkylating agents PRDX1 SSL via PRDX1 1
enzastaurin, bevacizumab, enzyme-inducing antiepileptic drugs (eiaed), non-enzyme inducing antiepileptic drugs (neiaed) PIK3R1 SSL via PIK3R1 1
enzastaurin, lomustine PIK3R1 SSL via PIK3R1 1
enzastaurin, temozolomide, radiation therapy PIK3R1 SSL via PIK3R1 1
erlotinib hydrochloride, selumetinib, laboratory biomarker analysis MAP2K1 SSL via MAP2K1 1
gemcitabine, ribociclib, sonidegib, trametinib, filgrastim MAP2K1 SSL via MAP2K1 1
gsk2256098, trametinib MAP2K1 SSL via MAP2K1 1
mebendazole TUBA1A SSL via TUBA1A 1
mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan TUBA1A SSL via TUBA1A 1
mirdametinib MAP2K1 SSL via MAP2K1 1
nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, fluorouracil, atezolizumab, cobimetinib, pegph20, bl-8040, selicrelumab, bevacizumab, ro6874281, ab928, tiragolumab, tocilizumab MAP2K1 SSL via MAP2K1 1
omeprazole, melatonin CALR SSL via CALR 1
patupilone TUBA1A SSL via TUBA1A 1
pimasertib, gemcitabine, placebo MAP2K1 SSL via MAP2K1 1
recombinant interferon alfa-2b, cisplatin, sodium stibogluconate, dacarbazine, vinblastine TUBA1A SSL via TUBA1A 1
rmc-4630, cobimetinib, drug: osimertinib MAP2K1 SSL via MAP2K1 1
selumetinib MAP2K1 SSL via MAP2K1 yes 1
tovorafenib, pimasertib MAP2K1 SSL via MAP2K1 1
trametinib, erlotinib MAP2K1 SSL via MAP2K1 1
trametinib, ruxolitinib MAP2K1 SSL via MAP2K1 1
trametinib, ruxolitinib, retifanlimab MAP2K1 SSL via MAP2K1 1
trametinib, vinblastine MAP2K1 SSL via MAP2K1 1
trametinib, vinblastine TUBA1A SSL via TUBA1A 1
belantamab mafodotin TUBA1A SSL via TUBA1A yes 0
cobimetinib MAP2K1 SSL via MAP2K1 yes 0
cobimetinib fumarate MAP2K1 SSL via MAP2K1 yes 0
dasatinib YES1 SSL via YES1 yes 0
docetaxel TUBA1A SSL via TUBA1A yes 0
eribulin TUBA1A SSL via TUBA1A yes 0
eribulin mesylate TUBA1A SSL via TUBA1A yes 0
midostaurin PRKCI SSL via PRKCI yes 0
selumetinib sulfate MAP2K1 SSL via MAP2K1 yes 0
trametinib MAP2K1 SSL via MAP2K1 yes 0
trametinib dimethyl sulfoxide MAP2K1 SSL via MAP2K1 yes 0
vandetanib YES1 SSL via YES1 yes 0
vinblastine TUBA1A SSL via TUBA1A yes 0
vinblastine sulfate TUBA1A SSL via TUBA1A yes 0
vincristine TUBA1A SSL via TUBA1A yes 0
vincristine sulfate TUBA1A SSL via TUBA1A yes 0
vindesine TUBA1A SSL via TUBA1A yes 0
vindesine sulfate TUBA1A SSL via TUBA1A yes 0
vinflunine TUBA1A SSL via TUBA1A yes 0
vinorelbine TUBA1A SSL via TUBA1A yes 0
vinorelbine tartrate TUBA1A SSL via TUBA1A yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.