Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 197 matching drugs for HDAC3 — including drugs targeting any of its 53 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study HDAC3 Direct 2
pembrolizumab, guadecitabine, mocetinostat HDAC3 Direct 2
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat HDAC3 Direct 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat HDAC3 Direct 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab HDAC3 Direct 1
bevacizumab, temozolomide, vorinostat HDAC3 Direct 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor HDAC3 Direct 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff HDAC3 Direct 1
laboratory biomarker analysis, pharmacological study, temozolomide, vorinostat HDAC3 Direct 1
pembrolizumab, vorinostat, temozolomide, radiotherapy HDAC3 Direct 1
vorinostat, bevacizumab HDAC3 Direct 1
vorinostat, bevacizumab, irinotecan HDAC3 Direct 1
vorinostat, bortezomib, pharmacological study, laboratory biomarker analysis HDAC3 Direct 1
vorinostat, conventional surgery HDAC3 Direct 1
vorinostat, temozolomide, diagnostic laboratory biomarker analysis, pharmacological study HDAC3 Direct 1
vorinostat, temozolomide, magnetic resonance spectroscopic imaging, survey administration HDAC3 Direct 1
vorinostat, therapeutic conventional surgery, bortezomib HDAC3 Direct 1
belinostat HDAC3 Direct yes 0
panobinostat HDAC3 Direct yes 0
panobinostat lactate HDAC3 Direct yes 0
romidepsin HDAC3 Direct yes 0
vorinostat HDAC3 Direct yes 0
afatinib EGFR SSL via EGFR yes 2
dacomitinib EGFR SSL via EGFR yes 2
erlotinib EGFR SSL via EGFR yes 2
gefitinib EGFR SSL via EGFR yes 2
lazertinib and amivantamab EGFR SSL via EGFR 1
osimertinib EGFR SSL via EGFR yes 1
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib AKT1 SSL via AKT1 3
alendronate, etidronate, ibandronate, risedronate, raloxifene ESR1 SSL via ESR1 2
eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab ESR1 SSL via ESR1 2
entinostat HDAC1 SSL via HDAC1 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study HDAC1 SSL via HDAC1 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study HDAC2 SSL via HDAC2 2
gefitinib, fulvestrant, erlotinib ESR1 SSL via ESR1 2
pazopanib SH2B3 SSL via SH2B3 2
pembrolizumab, guadecitabine, mocetinostat HDAC1 SSL via HDAC1 2
pembrolizumab, guadecitabine, mocetinostat HDAC2 SSL via HDAC2 2
pharmacological study, romidepsin HDAC1 SSL via HDAC1 2
pharmacological study, romidepsin HDAC2 SSL via HDAC2 2
pharmacological study, romidepsin HDAC4 SSL via HDAC4 2
sy-5609, fulvestrant, gemcitabine, nab-paclitaxel ESR1 SSL via ESR1 2
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat HDAC1 SSL via HDAC1 1
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat HDAC2 SSL via HDAC2 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat HDAC1 SSL via HDAC1 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat HDAC2 SSL via HDAC2 1
adjuvant therapy, temozolomide, valproic acid, radiation therapy HDAC1 SSL via HDAC1 1
adjuvant therapy, temozolomide, valproic acid, radiation therapy HDAC2 SSL via HDAC2 1
adriamycin, cyclophosphamide, vindesine, valproic acid HDAC1 SSL via HDAC1 1
adriamycin, cyclophosphamide, vindesine, valproic acid HDAC2 SSL via HDAC2 1
arsenic trioxide AKT1 SSL via AKT1 1
arsenic trioxide HDAC1 SSL via HDAC1 1
arsenic trioxide, radiation therapy AKT1 SSL via AKT1 1
arsenic trioxide, radiation therapy HDAC1 SSL via HDAC1 1
arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy AKT1 SSL via AKT1 1
arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy HDAC1 SSL via HDAC1 1
atorvastatin, temozolomide, radiotherapy HDAC2 SSL via HDAC2 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab HDAC1 SSL via HDAC1 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab HDAC2 SSL via HDAC2 1
belinostat, cisplatin, etoposide HDAC1 SSL via HDAC1 1
bevacizumab, temozolomide, vorinostat HDAC1 SSL via HDAC1 1
bevacizumab, temozolomide, vorinostat HDAC2 SSL via HDAC2 1
biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan ATR SSL via ATR 1
blu-222, carboplatin, ribociclib, fulvestrant ESR1 SSL via ESR1 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor HDAC1 SSL via HDAC1 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor HDAC2 SSL via HDAC2 1
capivasertib AKT1 SSL via AKT1 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin TP53 SSL via TP53 1
ceralasertib, olaparib, durvalumab ATR SSL via ATR 1
cisplatin, carboplatin, etoposide, durvalumab, ceralasertib ATR SSL via ATR 1
cytoreductive surgery, perifosine, temsirolimus AKT1 SSL via AKT1 1
decitabine, gemcitabine HDAC1 SSL via HDAC1 1
entinostat, nivolumab, entinostat, nivolumab HDAC1 SSL via HDAC1 1
enzastaurin, bevacizumab, enzyme-inducing antiepileptic drugs (eiaed), non-enzyme inducing antiepileptic drugs (neiaed) AKT1 SSL via AKT1 1
enzastaurin, bevacizumab, enzyme-inducing antiepileptic drugs (eiaed), non-enzyme inducing antiepileptic drugs (neiaed) PIK3R1 SSL via PIK3R1 1
enzastaurin, lomustine AKT1 SSL via AKT1 1
enzastaurin, lomustine PIK3R1 SSL via PIK3R1 1
enzastaurin, temozolomide, radiation therapy AKT1 SSL via AKT1 1
enzastaurin, temozolomide, radiation therapy PIK3R1 SSL via PIK3R1 1
fingolimod HDAC1 SSL via HDAC1 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff HDAC1 SSL via HDAC1 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff HDAC2 SSL via HDAC2 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride AKT1 SSL via AKT1 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride ESR1 SSL via ESR1 1
irinotecan, cisplatin, simvastatin HDAC2 SSL via HDAC2 1
laboratory biomarker analysis, perifosine, temsirolimus, therapeutic conventional surgery AKT1 SSL via AKT1 1
laboratory biomarker analysis, pharmacological study, temozolomide, vorinostat HDAC1 SSL via HDAC1 1
laboratory biomarker analysis, pharmacological study, temozolomide, vorinostat HDAC2 SSL via HDAC2 1
levonorgestrel, metformin ESR1 SSL via ESR1 1
omeprazole, melatonin ESR1 SSL via ESR1 1
pazopanib, 5-fu, oxaliplatin, leukovorin (flo) SH2B3 SSL via SH2B3 1
pazopanib, lapatinib SH2B3 SSL via SH2B3 1
pazopanib, placebo SH2B3 SSL via SH2B3 1
pegilodecakin, paclitaxel or docetaxel and carboplatin or cisplatin, folfox (oxaliplatin/leucovorin/5-fluorouracil), gemcitabine/nab-paclitaxel, capecitabine, pazopanib, pembrolizumab, paclitaxel, nivolumab, gemcitabine/carboplatin SH2B3 SSL via SH2B3 1
pembrolizumab, vorinostat, temozolomide, radiotherapy HDAC1 SSL via HDAC1 1
pembrolizumab, vorinostat, temozolomide, radiotherapy HDAC2 SSL via HDAC2 1
perifosine AKT1 SSL via AKT1 1
pf-07220060, letrozole, fulvestrant, midazolam, enzalutamide ESR1 SSL via ESR1 1
porfimer sodium LDLR SSL via LDLR 1
porfimer sodium, adjuvant therapy, conventional surgery LDLR SSL via LDLR 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.