Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 23 of 23 matching drugs for HDAC7 — including drugs targeting any of its 8 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
belinostat HDAC7 Direct yes 0
panobinostat HDAC7 Direct yes 0
panobinostat lactate HDAC7 Direct yes 0
romideps HDAC7 Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
sotorasib KRAS SSL via KRAS yes 2
7-hydroxystaurosporine, irinotecan hydrochloride, diagnostic laboratory biomarker analysis PDPK1 SSL via PDPK1 3
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy PDPK1 SSL via PDPK1 2
cpt- 11, cisplatin, celecoxib, radiation, surgery PDPK1 SSL via PDPK1 2
7-hydroxystaurosporine, fluorouracil PDPK1 SSL via PDPK1 1
7-hydroxystaurosporine, gemcitabine hydrochloride, pharmacological study, laboratory biomarker analysis PDPK1 SSL via PDPK1 1
botensilimab, balstilimab, chloroquine phosphate, celecoxib PDPK1 SSL via PDPK1 1
celecoxib, cyclophosphamide, etoposide, thalidomide PDPK1 SSL via PDPK1 1
celecoxib, isotretinoin, temozolomide, thalidomide PDPK1 SSL via PDPK1 1
celecoxib, temozolomide, thalidomide, adjuvant therapy PDPK1 SSL via PDPK1 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin PDPK1 SSL via PDPK1 1
topotecan hydrochloride, 7-hydroxystaurosporine PDPK1 SSL via PDPK1 1
dextrothyroxine THRB SSL via THRB yes 0
dextrothyroxine sodium THRB SSL via THRB yes 0
levothyroxine THRB SSL via THRB yes 0
levothyroxine sodium THRB SSL via THRB yes 0
liothyronine THRB SSL via THRB yes 0
liothyronine sodium THRB SSL via THRB yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.