Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 1250 matching drugs for KIT — including drugs targeting any of its 239 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
sunitinib KIT Direct yes 5
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab KIT Direct 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) KIT Direct 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib KIT Direct 3
pembrolizumab, belzutifan, lenvatinib KIT Direct 3
avapritinib KIT Direct yes 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment KIT Direct 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a KIT Direct 2
lenvatinib, pembrolizumab KIT Direct 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate KIT Direct 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a KIT Direct 2
pazopanib KIT Direct yes 2
pembrolizumab, lenvatinib KIT Direct 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu KIT Direct 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin KIT Direct 2
regorafenib KIT Direct yes 2
regorafenib, laboratory biomarker analysis KIT Direct 2
sorafenib, administered orally, ct/mri KIT Direct 2
afatinib, dasatinib, palbociclib, everolimus, olaparib KIT Direct 1
atezolizumab, tivozanib KIT Direct 1
avapritinib, midazolam KIT Direct 1
bevacizumab, dasatinib, placebo KIT Direct 1
biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging, sunitinib KIT Direct 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging KIT Direct 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography KIT Direct 1
cisplatin, pemetrexed disodium, sorafenib KIT Direct 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride KIT Direct 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method KIT Direct 1
dasatinib, laboratory biomarker analysis, physiologic testing KIT Direct 1
dasatinib, mfolfox6 KIT Direct 1
dasatinib, pharmacological study KIT Direct 1
dasatinib, temozolomide, placebo, radiation therapy KIT Direct 1
erdafitinib KIT Direct 1
everolimus, sorafenib KIT Direct 1
gemcitabine, erlotinib, sorafenib KIT Direct 1
gemcitabine, oxaliplatin, imatinib KIT Direct 1
gemcitabine, placebo, sorafenib KIT Direct 1
gemcitabine, sorafenib, radiotherapy KIT Direct 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff KIT Direct 1
gemcitabine, sunitinib KIT Direct 1
h101, tislelizumab, lenvatinib KIT Direct 1
imatinib, irinotecan, carboplatin KIT Direct 1
lenalidomide, bevacizumab, sorafenib, temsirolimus, lenalidomide, oxaliplatin, leucovorin, 5-fluorouracil KIT Direct 1
lenvatinib, bevacizumab KIT Direct 1
oxaliplatin, sorafenib KIT Direct 1
paclitaxel, irinotecan, pembrolizumab, mk-4830, lenvatinib, sacituzumab tirumotecan, antihistamine, h2 receptor antagonist, acetaminophen (or equivalent), dexamethasone (or equivalent) KIT Direct 1
pazopanib, 5-fu, oxaliplatin, leukovorin (flo) KIT Direct 1
pazopanib, lapatinib KIT Direct 1
pazopanib, placebo KIT Direct 1
pegilodecakin, paclitaxel or docetaxel and carboplatin or cisplatin, folfox (oxaliplatin/leucovorin/5-fluorouracil), gemcitabine/nab-paclitaxel, capecitabine, pazopanib, pembrolizumab, paclitaxel, nivolumab, gemcitabine/carboplatin KIT Direct 1
pembrolizumab, coformulation favezelimab/pembrolizumab, mk-4830, lenvatinib, irinotecan, paclitaxel KIT Direct 1
pembrolizumab, lenvatinib, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, paclitaxel KIT Direct 1
pexidartinib, durvalumab KIT Direct 1
ponatinib KIT Direct 1
radiation therapy, temozolomide, sorafenib KIT Direct 1
regorafenib, lomustine KIT Direct 1
regorafenib, nivolumab, capeox, folfox regimen KIT Direct 1
regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil KIT Direct 1
regorafenib, temozolomide KIT Direct 1
ryz101, everolimus, sunitinib, octreotide, lanreotide KIT Direct 1
serplulimab, lenvatinib, paclitaxel/paclitaxel-albumin/paclitaxel liposome KIT Direct 1
sorafenib KIT Direct yes 1
sorafenib, erlotinb KIT Direct 1
sorafenib, rad001 KIT Direct 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide KIT Direct 1
sunitinib, placebo KIT Direct 1
sunitinib, radiation KIT Direct 1
sunitinib, sunitinib KIT Direct 1
tace, lenvatinib, combined with tislelizumab group KIT Direct 1
tace, tislelizumab, lenvatinib KIT Direct 1
temozolomide, lomustine, regorafenib, radiation, paxalisib, val-083, vt1021, troriluzole, adi-peg 20 KIT Direct 1
tivozanib KIT Direct 1
topotecan, pazopanib KIT Direct 1
topotecan, sorafenib KIT Direct 1
trc 105, sorafenib KIT Direct 1
vemurafenib, sorafenib KIT Direct 1
axitinib KIT Direct yes 0
dasatinib KIT Direct yes 0
imatinib KIT Direct yes 0
imatinib mesylate KIT Direct yes 0
midostaurin KIT Direct yes 0
pazopanib hydrochloride KIT Direct yes 0
pexidartinib KIT Direct yes 0
pexidartinib hydrochloride KIT Direct yes 0
ripretinib KIT Direct yes 0
sorafenib tosylate KIT Direct yes 0
sunitinib malate KIT Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
afatinib EGFR SSL via EGFR yes 2
dacomitinib EGFR SSL via EGFR yes 2
erlotinib EGFR SSL via EGFR yes 2
gefitinib EGFR SSL via EGFR yes 2
sotorasib KRAS SSL via KRAS yes 2
binimetinib and encorafenib BRAF SSL via BRAF yes 1
lazertinib and amivantamab EGFR SSL via EGFR 1
osimertinib EGFR SSL via EGFR yes 1
sunitinib KDR SSL via KDR yes 5
sunitinib MET SSL via MET 5
sunitinib PDGFRA SSL via PDGFRA yes 5
sunitinib PDGFRB SSL via PDGFRB yes 5
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.