Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | MST1R | Direct | 3 | ||||||||
| crizotinib | MST1R | Direct | 3 | ||||||||
| biopsy, biospecimen collection, crizotinib, radiologic examination | MST1R | Direct | 1 | ||||||||
| adagrasib | KRAS | SSL via KRAS | yes | 2 | |||||||
| sotorasib | KRAS | SSL via KRAS | yes | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | MAP2K2 | SSL via MAP2K2 | 3 | ||||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | TOP1 | SSL via TOP1 | 3 | ||||||||
| lurbinectedin, irinotecan | TOP1 | SSL via TOP1 | 3 | ||||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | MAP2K2 | SSL via MAP2K2 | 2 | ||||||||
| apatinib, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | TOP1 | SSL via TOP1 | 2 | ||||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | MAP2K2 | SSL via MAP2K2 | 2 | ||||||||
| bryostatin 1, paclitaxel | PRKCA | SSL via PRKCA | 2 | ||||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | TOP1 | SSL via TOP1 | 2 | ||||||||
| cft1946, trametinib, cetuximab | MAP2K2 | SSL via MAP2K2 | 2 | ||||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | TOP1 | SSL via TOP1 | 2 | ||||||||
| irinotecan, capecitabine | TOP1 | SSL via TOP1 | 2 | ||||||||
| irinotecan, docetaxel | TOP1 | SSL via TOP1 | 2 | ||||||||
| jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib | MAP2K2 | SSL via MAP2K2 | 2 | ||||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | TOP1 | SSL via TOP1 | 2 | ||||||||
| pazopanib | SH2B3 | SSL via SH2B3 | 2 | ||||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| rubitecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| sacituzumab govitecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| selumetinib, medi4736, tremelimumab | MAP2K2 | SSL via MAP2K2 | 2 | ||||||||
| topotecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| trastuzumab deruxtecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | TOP1 | SSL via TOP1 | 1 | ||||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| adriamycin, cyclophosphamide, vindesine, valproic acid | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| afatinib, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| aldoxorubicin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| amrubicin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| arsenic trioxide | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| arsenic trioxide, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy | CDKN1A | SSL via CDKN1A | 1 | ||||||||
| at-101, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avastin, temozolomide, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avastin, temozolomide, radiation therapy (xrt), irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avelumab, irinotecan, paclitaxel, best supportive care (bsc) | TOP1 | SSL via TOP1 | 1 | ||||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | TOP1 | SSL via TOP1 | 1 | ||||||||
| azenosertib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, multigated acquisition scan, trastuzumab deruxtecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | TOP1 | SSL via TOP1 | 1 | ||||||||
| bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| berzosertib, sacituzumab govitecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab [avastin], irinotecan, temozolomide | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, temozolomide, radiation therapy (xrt), topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bi 764532, topotecan, single agent chemotherapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| binimetinib | MAP2K2 | SSL via MAP2K2 | yes | 1 | |||||||
| binimetinib, hydroxychloroquine | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan | ATR | SSL via ATR | 1 | ||||||||
| biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin | TOP1 | SSL via TOP1 | 1 | ||||||||
| biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab | TOP1 | SSL via TOP1 | 1 | ||||||||
| bl-b01d1, irinotecan, paclitaxel, docetaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| bl-b01d1, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bortezomib, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bosutinib | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| camrelizumab, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib | TOP1 | SSL via TOP1 | 1 | ||||||||
| capecitabine, oxaliplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| carboplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study | TOP1 | SSL via TOP1 | 1 | ||||||||
| ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin | TP53 | SSL via TP53 | 1 | ||||||||
| ceralasertib, olaparib, durvalumab | ATR | SSL via ATR | 1 | ||||||||
| cetuximab, bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| cetuximab, irinotecan, oxaliplatin, uft | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, carboplatin, etoposide, durvalumab, ceralasertib | ATR | SSL via ATR | 1 | ||||||||
| cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, gleevec™, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, irinotecan, capecitabine | TOP1 | SSL via TOP1 | 1 | ||||||||
| cytoreductive surgery, perifosine, temsirolimus | PRKCA | SSL via PRKCA | 1 | ||||||||
| dabrafenib, trametinib | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| dabrafenib, trametinib, carboplatin, vincristine | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| doxorubicin, cisplatin, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf | TOP1 | SSL via TOP1 | 1 | ||||||||
| edotecarin, temozolomide, carmustine (bcnu), lomustine (ccnu) | TOP1 | SSL via TOP1 | 1 | ||||||||
| erlotinib hydrochloride, selumetinib, laboratory biomarker analysis | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| fluorouracil (5-fu), capecitabine, durvalumab, oxaliplatin, trastuzumab, trastuzumab deruxtecan, cisplatin, pembrolizumab, volrustomig, rilvegostomig | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, oxaliplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) | TOP1 | SSL via TOP1 | 1 | ||||||||
| gemcitabine, ribociclib, sonidegib, trametinib, filgrastim | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| gemcitabine, taxotere, xeloda, cisplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| gsk2256098, trametinib | MAP2K2 | SSL via MAP2K2 | 1 | ||||||||
| ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| imatinib, irinotecan, carboplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan hydrochloride liposome injection, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, 5-fluorouracil, leucovorin | TOP1 | SSL via TOP1 | 1 |