Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 100 of 360 matching drugs for NR1I2 — including drugs targeting any of its 44 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
docetaxel, thalidomide NR1I2 Direct 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab NR1I2 Direct 4
amg 193, docetaxel, comparator amg 193 test tablet NR1I2 Direct 3
bms-986340, bms-936558-01, docetaxel NR1I2 Direct 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel NR1I2 Direct 2
alvocidib, paclitaxel NR1I2 Direct 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan NR1I2 Direct 2
bbi-355, erlotinib, futibatinib NR1I2 Direct 2
biopsy, biospecimen collection, computed tomography, cyclophosphamide, fludarabine phosphate, fludeoxyglucose f-18, il13ralpha2-specific hinge-optimized 4-1bb-co-stimulatory car/truncated cd19-expressing autologous tn/mem cells, magnetic resonance imaging, positron emission tomography NR1I2 Direct 2
bpi-7711, bpi-7711, itraconazole, rifampicin NR1I2 Direct 2
bryostatin 1, paclitaxel NR1I2 Direct 2
btla inhibitor (js004), toripalimab, paclitaxel, cisplatin NR1I2 Direct 2
capecitabine, docetaxel NR1I2 Direct 2
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy NR1I2 Direct 2
carboplatin, docetaxel NR1I2 Direct 2
carboplatin, endoscopic biopsy, external beam radiation therapy, lenvatinib mesylate, paclitaxel, pembrolizumab, resection NR1I2 Direct 2
carboplatin, esophagectomy, intensity-modulated radiation therapy, paclitaxel, proton beam radiation therapy, quality-of-life assessment, questionnaire administration, folfox regimen, capox regimen, docetaxel, 5fu NR1I2 Direct 2
carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy NR1I2 Direct 2
carboplatin, paclitaxel, panitumumab, radiotherapy NR1I2 Direct 2
carboplatin, paclitaxel, radiation therapy, telomerase-specific type 5 adenovirus obp-301 NR1I2 Direct 2
carboplatin, paclitaxel, three-dimensional conformal radiation therapy NR1I2 Direct 2
cetuximab, cisplatin, docetaxel, adjuvant therapy, neoadjuvant therapy NR1I2 Direct 2
chemotherapy, cisplatin, paclitaxel, low-let electron therapy, low-let photon therapy NR1I2 Direct 2
cisplatin, docetaxel, irinotecan hydrochloride, radiation therapy NR1I2 Direct 2
cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy NR1I2 Direct 2
cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy NR1I2 Direct 2
cisplatin, paclitaxel, surgical procedure, radiation therapy NR1I2 Direct 2
cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study NR1I2 Direct 2
cyclophosphamide, neoantigen peptide vaccine, pembrolizumab, sargramostim NR1I2 Direct 2
dkn-01 150 mg, paclitaxel, pembrolizumab, dkn-01 300 mg NR1I2 Direct 2
docetaxel, 5-fu, radiotherapy, esophagectomy, dexamethasone NR1I2 Direct 2
durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel NR1I2 Direct 2
erlotinib NR1I2 Direct 2
filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy NR1I2 Direct 2
filgrastim, paclitaxel, topotecan hydrochloride NR1I2 Direct 2
filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy NR1I2 Direct 2
gefitinib, fulvestrant, erlotinib NR1I2 Direct 2
gemcitabine hydrochloride, paclitaxel, tipifarnib, radiation therapy NR1I2 Direct 2
hlx208, hlx208, hlx208, hlx208, itraconazole 200 mg, rifampicin NR1I2 Direct 2
irinotecan, docetaxel NR1I2 Direct 2
itraconazole, rifampicin NR1I2 Direct 2
ksq-001ex, interleukin-2, cyclophosphamide, fludarabine NR1I2 Direct 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed NR1I2 Direct 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a NR1I2 Direct 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine NR1I2 Direct 2
onc-392, pembrolizumab, docetaxel NR1I2 Direct 2
paclitaxel NR1I2 Direct 2
pembrolizumab, paclitaxel NR1I2 Direct 2
pembrolizumab, paclitaxel, docetaxel, irinotecan NR1I2 Direct 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin NR1I2 Direct 2
pentostatin, cyclophosphamide, ss1(dsfv)pe38 - lot 073i0809, ss1(dsfv)pe38 - lot fil129j01 NR1I2 Direct 2
pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography NR1I2 Direct 2
ramucirumab, paclitaxel NR1I2 Direct 2
5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) NR1I2 Direct 1
5-fluorouracil, docetaxel, oxaliplatin NR1I2 Direct 1
5-fluorouracil, leucovorin, oxaliplatin, docetaxel, carboplatin, paclitaxel, neoadjuvant radiation NR1I2 Direct 1
5-fluoruracil, cisplatinum, docetaxel NR1I2 Direct 1
5-fu, leucovorin, docetaxel, oxaliplatin (flot), trastuzumab, post-operative treatment trastuzumab mono therapy NR1I2 Direct 1
adriamycin, cyclophosphamide, vindesine, valproic acid NR1I2 Direct 1
aerosol sargramostim, sargramostim, cisplatin, doxorubicin hydrochloride, ifosfamide, mitomycin c, flow cytometry, immunological diagnostic method, laboratory biomarker analysis, adjuvant therapy, multimodality therapy, neoadjuvant therapy, therapeutic conventional surgery, intraoperative radiation therapy, selective external radiation therapy NR1I2 Direct 1
afatinib, docetaxel, radiation therapy NR1I2 Direct 1
afuresertib, nab paclitaxel, docetaxel, sintilimab NR1I2 Direct 1
agent-797, botensilimab, balstilimab, ramucirumab, paclitaxel NR1I2 Direct 1
ak109, paclitaxel, paclitaxel, ak104 NR1I2 Direct 1
aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation NR1I2 Direct 1
aldesleukin, biopsy, biospecimen collection, computed tomography, cyclophosphamide, excisional biopsy, fludarabine, magnetic resonance imaging, standard treatment, therapeutic tumor infiltrating lymphocytes NR1I2 Direct 1
allogeneic tumor cell vaccine, recombinant interferon alfa, sargramostim, cyclophosphamide NR1I2 Direct 1
alvocidib, docetaxel NR1I2 Direct 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel NR1I2 Direct 1
anetumab ravtansine, bevacizumab, paclitaxel NR1I2 Direct 1
anti-thymocyte globulin, filgrastim, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy NR1I2 Direct 1
anti-thymocyte globulin, filgrastim, busulfan, cyclophosphamide, methylprednisolone, umbilical cord blood transplantation, radiation therapy NR1I2 Direct 1
apixaban, dabigatran, rivaroxaban, warfarin NR1I2 Direct 1
apixaban, dabigatran, rivaroxaban, warfarin, antiplatelets NR1I2 Direct 1
apixaban, rivaroxaban, edoxaban, dabigatran, acenocoumarol, phenindione, warfarin NR1I2 Direct 1
apixaban, warfarin NR1I2 Direct 1
atezolizumab, 5-fluorouracil, calciumfolinat, oxaliplatin, docetaxel NR1I2 Direct 1
atezolizumab, biospecimen collection, capecitabine, computed tomography, docetaxel, echocardiography, fluorouracil, leucovorin calcium, lymphadenectomy, magnetic resonance imaging, oxaliplatin, positron emission tomography, surgical procedure NR1I2 Direct 1
atezolizumab, tiragolumab, paclitaxel, cisplatin, atezolizumab matching placebo, tiragolumab matching placebo NR1I2 Direct 1
autologous mesothelin-specific tcr-t cells, cyclophosphamide, fludarabine, bendamustine NR1I2 Direct 1
autologous tumor cell vaccine, sargramostim, tumor-draining lymph node lymphocyte therapy, cyclophosphamide, conventional surgery NR1I2 Direct 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) NR1I2 Direct 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab NR1I2 Direct 1
azd6244, dacarbazine, erlotinib, docetaxel, temsirolimus NR1I2 Direct 1
bbi608, paclitaxel, placebo NR1I2 Direct 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil NR1I2 Direct 1
bendamustine, biopsy, biospecimen collection, computed tomography, cyclophosphamide, echocardiography, fludarabine, leukapheresis, magnetic resonance imaging, multigated acquisition scan, positron emission tomography, t-cell receptor-engineered t-cells NR1I2 Direct 1
bevacizumab, docetaxel, oxaliplatin NR1I2 Direct 1
bevacizumab, erlotinib, gemcitabine NR1I2 Direct 1
biological ni-1801, ni-1801 in combination with anti-pd1 (pembrolizumab), ni-1801 in combination with paclitaxel, paclitaxel NR1I2 Direct 1
biospecimen collection, computed tomography, endoscopic ultrasound, esophagogastroduodenoscopy, fluorouracil, hypofractionated radiation therapy, leucovorin calcium, oxaliplatin, positron emission tomography, survey administration, docetaxel NR1I2 Direct 1
biospecimen collection, computed tomography, magnetic resonance imaging, nivolumab, paclitaxel, questionnaire administration, ramucirumab NR1I2 Direct 1
bl-b01d1, irinotecan, paclitaxel, docetaxel NR1I2 Direct 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan NR1I2 Direct 1
bortezomib, carboplatin, paclitaxel NR1I2 Direct 1
cadonilimab, ak117, oxaliplatin, tegafur-gimeracil-oteracil potassium, docetaxel, 5-fluorouracil NR1I2 Direct 1
cadonilimab, pulocimab, paclitaxel, placebo NR1I2 Direct 1
cadonilimab, radiotherapy, carboplatin, paclitaxel NR1I2 Direct 1
camrelizumab, docetaxel, irinotecan NR1I2 Direct 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib NR1I2 Direct 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.