Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 49 of 49 matching drugs for P4HB — including drugs targeting any of its 17 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
disulfiram, copper, alkylating agents P4HB Direct 1
lomitapide P4HB Direct yes 0
lomitapide mesylate P4HB Direct yes 0
alendronate, etidronate, ibandronate, risedronate, raloxifene ESR1 SSL via ESR1 2
eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab ESR1 SSL via ESR1 2
gefitinib, fulvestrant, erlotinib ESR1 SSL via ESR1 2
sy-5609, fulvestrant, gemcitabine, nab-paclitaxel ESR1 SSL via ESR1 2
blu-222, carboplatin, ribociclib, fulvestrant ESR1 SSL via ESR1 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin TP53 SSL via TP53 1
disulfiram, copper, alkylating agents PDIA3 SSL via PDIA3 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride ESR1 SSL via ESR1 1
levonorgestrel, metformin ESR1 SSL via ESR1 1
omeprazole, melatonin ESR1 SSL via ESR1 1
pf-07220060, letrozole, fulvestrant, midazolam, enzalutamide ESR1 SSL via ESR1 1
porfimer sodium LDLR SSL via LDLR 1
porfimer sodium, adjuvant therapy, conventional surgery LDLR SSL via LDLR 1
porfimer sodium, endoscopic ultrasonography, photodynamic therapy, gemcitabine hydrochloride LDLR SSL via LDLR 1
tamoxifen, etoposide ESR1 SSL via ESR1 1
allylestrenol ESR1 SSL via ESR1 yes 0
bazedoxifene ESR1 SSL via ESR1 yes 0
bazedoxifene acetate ESR1 SSL via ESR1 yes 0
clomiphene ESR1 SSL via ESR1 yes 0
clomiphene citrate ESR1 SSL via ESR1 yes 0
cyclofenil ESR1 SSL via ESR1 yes 0
danazol ESR1 SSL via ESR1 yes 0
dienestrol ESR1 SSL via ESR1 yes 0
diethylstilbestrol ESR1 SSL via ESR1 yes 0
diethylstilbestrol diphosphate ESR1 SSL via ESR1 yes 0
estetrol ESR1 SSL via ESR1 yes 0
estradiol ESR1 SSL via ESR1 yes 0
estradiol acetate ESR1 SSL via ESR1 yes 0
estradiol benzoate ESR1 SSL via ESR1 yes 0
estradiol cypionate ESR1 SSL via ESR1 yes 0
estradiol valerate ESR1 SSL via ESR1 yes 0
estriol ESR1 SSL via ESR1 yes 0
estrone ESR1 SSL via ESR1 yes 0
estrone sulfuric acid ESR1 SSL via ESR1 yes 0
estropipate ESR1 SSL via ESR1 yes 0
ethinyl estradiol ESR1 SSL via ESR1 yes 0
fulvestrant ESR1 SSL via ESR1 yes 0
lasofoxifene ESR1 SSL via ESR1 yes 0
mestranol ESR1 SSL via ESR1 yes 0
ospemifene ESR1 SSL via ESR1 yes 0
polyestradiol phosphate ESR1 SSL via ESR1 yes 0
quinestrol ESR1 SSL via ESR1 yes 0
tamoxifen ESR1 SSL via ESR1 yes 0
tamoxifen citrate ESR1 SSL via ESR1 yes 0
toremifene ESR1 SSL via ESR1 yes 0
toremifene citrate ESR1 SSL via ESR1 yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.