Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 113 matching drugs for PARP3 — including drugs targeting any of its 93 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
olaparib PARP3 Direct 2
18f-fluoromisonidazole, cediranib maleate, laboratory biomarker analysis, olaparib, positron emission tomography PARP3 Direct 1
afatinib, dasatinib, palbociclib, everolimus, olaparib PARP3 Direct 1
azd1775, olaparib PARP3 Direct 1
bevacizumab, cediranib, cediranib maleate, olaparib PARP3 Direct 1
biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, olaparib PARP3 Direct 1
biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, olaparib, pembrolizumab PARP3 Direct 1
biospecimen collection, computed tomography, magnetic resonance imaging, olaparib, placebo administration PARP3 Direct 1
capecitabine, medi4736 (durvalumab), trastuzumab, rucaparib, ramucirumab PARP3 Direct 1
ceralasertib, olaparib, durvalumab PARP3 Direct 1
cobimetinib, olaparib, onvansertib, azenosertib, saruparib, tremelimumab PARP3 Direct 1
durvalumab, olaparib PARP3 Direct 1
durvalumab, olaparib, cediranib PARP3 Direct 1
ep0057, olaparib PARP3 Direct 1
fluorouracil, irinotecan sucrosofate, laboratory biomarker analysis, leucovorin calcium, rucaparib PARP3 Direct 1
nab-paclitaxel, gemcitabine, cisplatin, irinotecan, capecitabine, pembrolizumab, olaparib PARP3 Direct 1
olaparib, olaparib, placebo, placebo PARP3 Direct 1
olaparib, ramucirumab PARP3 Direct 1
olaparib, temozolomide (tmz), imrt (intensity modulated radiation therapy) PARP3 Direct 1
olaparib, temozolomide, gene expression analysis, protein expression analysis, laboratory biomarker analysis, pharmacological study, diffusion-weighted magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging, therapeutic conventional surgery PARP3 Direct 1
olaparib, temozolomide, irinotecan PARP3 Direct 1
pamiparib, olaparib, radiation therapy, temozolomide PARP3 Direct 1
pembrolizumab, olaparib PARP3 Direct 1
pembrolizumab, olaparib, temozolomide PARP3 Direct 1
rucaparib PARP3 Direct 1
rucaparib, ramucirumab, nivolumab PARP3 Direct 1
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone PPARG SSL via PPARG 3
alendronate, etidronate, ibandronate, risedronate, raloxifene ESR1 SSL via ESR1 2
eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab ESR1 SSL via ESR1 2
gefitinib, fulvestrant, erlotinib ESR1 SSL via ESR1 2
sy-5609, fulvestrant, gemcitabine, nab-paclitaxel ESR1 SSL via ESR1 2
adjuvant therapy, temozolomide, valproic acid, radiation therapy PPARG SSL via PPARG 1
adriamycin, cyclophosphamide, vindesine, valproic acid PPARG SSL via PPARG 1
biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan ATR SSL via ATR 1
blu-222, carboplatin, ribociclib, fulvestrant ESR1 SSL via ESR1 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin CASP3 SSL via CASP3 1
ceralasertib, olaparib, durvalumab ATR SSL via ATR 1
cisplatin, carboplatin, etoposide, durvalumab, ceralasertib ATR SSL via ATR 1
curcumin PPARG SSL via PPARG 1
digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin ATP1A1 SSL via ATP1A1 1
dimethyl fumarate, temozolomide, radiation therapy KEAP1 SSL via KEAP1 1
durvalumab, tazemetostat EZH2 SSL via EZH2 1
enzastaurin, bevacizumab, enzyme-inducing antiepileptic drugs (eiaed), non-enzyme inducing antiepileptic drugs (neiaed) PIK3R1 SSL via PIK3R1 1
enzastaurin, lomustine PIK3R1 SSL via PIK3R1 1
enzastaurin, temozolomide, radiation therapy PIK3R1 SSL via PIK3R1 1
gabapentin, sulfasalazine, memantine, temozolomide, radiotherapy PPARG SSL via PPARG 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride ESR1 SSL via ESR1 1
glipizide PPARG SSL via PPARG 1
levonorgestrel, metformin ESR1 SSL via ESR1 1
medical cannabis PPARG SSL via PPARG 1
minocycline, placebo, questionnaires CASP3 SSL via CASP3 1
nabiximols, temozolomide, nabiximols-matched placebo PPARG SSL via PPARG 1
omeprazole, melatonin ESR1 SSL via ESR1 1
pf-07220060, letrozole, fulvestrant, midazolam, enzalutamide ESR1 SSL via ESR1 1
pioglitazone, pioglitazone PPARG SSL via PPARG 1
sorafenib tosylate, valproic acid, sildenafil citrate PPARG SSL via PPARG 1
sulfasalazine PPARG SSL via PPARG 1
tamoxifen, etoposide ESR1 SSL via ESR1 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin CASP3 SSL via CASP3 1
valproic acid PPARG SSL via PPARG 1
valproic acid, bevacizumab, radiation therapy PPARG SSL via PPARG 1
valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine PPARG SSL via PPARG 1
acetyldigitoxin ATP1A1 SSL via ATP1A1 yes 0
allylestrenol ESR1 SSL via ESR1 yes 0
ataluren RPL22 SSL via RPL22 yes 0
balsalazide PPARG SSL via PPARG yes 0
balsalazide disodium PPARG SSL via PPARG yes 0
bazedoxifene ESR1 SSL via ESR1 yes 0
bazedoxifene acetate ESR1 SSL via ESR1 yes 0
bezafibrate PPARG SSL via PPARG yes 0
clomiphene ESR1 SSL via ESR1 yes 0
clomiphene citrate ESR1 SSL via ESR1 yes 0
cyclofenil ESR1 SSL via ESR1 yes 0
danazol ESR1 SSL via ESR1 yes 0
deslanoside ATP1A1 SSL via ATP1A1 yes 0
dienestrol ESR1 SSL via ESR1 yes 0
diethylstilbestrol ESR1 SSL via ESR1 yes 0
diethylstilbestrol diphosphate ESR1 SSL via ESR1 yes 0
digitoxin ATP1A1 SSL via ATP1A1 yes 0
digoxin ATP1A1 SSL via ATP1A1 yes 0
dimethyl fumarate KEAP1 SSL via KEAP1 yes 0
diroximel fumarate KEAP1 SSL via KEAP1 yes 0
estetrol ESR1 SSL via ESR1 yes 0
estradiol ESR1 SSL via ESR1 yes 0
estradiol acetate ESR1 SSL via ESR1 yes 0
estradiol benzoate ESR1 SSL via ESR1 yes 0
estradiol cypionate ESR1 SSL via ESR1 yes 0
estradiol valerate ESR1 SSL via ESR1 yes 0
estriol ESR1 SSL via ESR1 yes 0
estrone ESR1 SSL via ESR1 yes 0
estrone sulfuric acid ESR1 SSL via ESR1 yes 0
estropipate ESR1 SSL via ESR1 yes 0
ethinyl estradiol ESR1 SSL via ESR1 yes 0
fulvestrant ESR1 SSL via ESR1 yes 0
lasofoxifene ESR1 SSL via ESR1 yes 0
mesalamine PPARG SSL via PPARG yes 0
mestranol ESR1 SSL via ESR1 yes 0
monomethyl fumarate KEAP1 SSL via KEAP1 yes 0
olsalazine PPARG SSL via PPARG yes 0
olsalazine sodium PPARG SSL via PPARG yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.