Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 1063 matching drugs for PDGFRB — including drugs targeting any of its 310 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
sunitinib PDGFRB Direct yes 5
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PDGFRB Direct 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) PDGFRB Direct 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PDGFRB Direct 3
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment PDGFRB Direct 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib PDGFRB Direct 2
nintedanib PDGFRB Direct yes 2
nintedanib, pembrolizumab PDGFRB Direct 2
pazopanib PDGFRB Direct yes 2
regorafenib PDGFRB Direct yes 2
regorafenib, laboratory biomarker analysis PDGFRB Direct 2
sorafenib, administered orally, ct/mri PDGFRB Direct 2
afatinib, dasatinib, palbociclib, everolimus, olaparib PDGFRB Direct 1
atezolizumab, tivozanib PDGFRB Direct 1
bevacizumab, dasatinib, placebo PDGFRB Direct 1
biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging, sunitinib PDGFRB Direct 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging PDGFRB Direct 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography PDGFRB Direct 1
byl719, poziotinib, nintedanib, abemaciclib, durvalumab,tremelimumab PDGFRB Direct 1
cisplatin, pemetrexed disodium, sorafenib PDGFRB Direct 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride PDGFRB Direct 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method PDGFRB Direct 1
dasatinib, laboratory biomarker analysis, physiologic testing PDGFRB Direct 1
dasatinib, mfolfox6 PDGFRB Direct 1
dasatinib, pharmacological study PDGFRB Direct 1
dasatinib, temozolomide, placebo, radiation therapy PDGFRB Direct 1
erdafitinib PDGFRB Direct 1
everolimus, sorafenib PDGFRB Direct 1
gemcitabine, erlotinib, sorafenib PDGFRB Direct 1
gemcitabine, oxaliplatin, imatinib PDGFRB Direct 1
gemcitabine, placebo, sorafenib PDGFRB Direct 1
gemcitabine, sorafenib, radiotherapy PDGFRB Direct 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff PDGFRB Direct 1
gemcitabine, sunitinib PDGFRB Direct 1
imatinib, irinotecan, carboplatin PDGFRB Direct 1
lenalidomide, bevacizumab, sorafenib, temsirolimus, lenalidomide, oxaliplatin, leucovorin, 5-fluorouracil PDGFRB Direct 1
oxaliplatin, sorafenib PDGFRB Direct 1
pazopanib, 5-fu, oxaliplatin, leukovorin (flo) PDGFRB Direct 1
pazopanib, lapatinib PDGFRB Direct 1
pazopanib, placebo PDGFRB Direct 1
pegilodecakin, paclitaxel or docetaxel and carboplatin or cisplatin, folfox (oxaliplatin/leucovorin/5-fluorouracil), gemcitabine/nab-paclitaxel, capecitabine, pazopanib, pembrolizumab, paclitaxel, nivolumab, gemcitabine/carboplatin PDGFRB Direct 1
pexidartinib, durvalumab PDGFRB Direct 1
radiation therapy, temozolomide, sorafenib PDGFRB Direct 1
regorafenib, lomustine PDGFRB Direct 1
regorafenib, nivolumab, capeox, folfox regimen PDGFRB Direct 1
regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil PDGFRB Direct 1
regorafenib, temozolomide PDGFRB Direct 1
ryz101, everolimus, sunitinib, octreotide, lanreotide PDGFRB Direct 1
sorafenib PDGFRB Direct yes 1
sorafenib, erlotinb PDGFRB Direct 1
sorafenib, rad001 PDGFRB Direct 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide PDGFRB Direct 1
sunitinib, placebo PDGFRB Direct 1
sunitinib, radiation PDGFRB Direct 1
sunitinib, sunitinib PDGFRB Direct 1
temozolomide, lomustine, regorafenib, radiation, paxalisib, val-083, vt1021, troriluzole, adi-peg 20 PDGFRB Direct 1
tivozanib PDGFRB Direct 1
topotecan, pazopanib PDGFRB Direct 1
topotecan, sorafenib PDGFRB Direct 1
trc 105, sorafenib PDGFRB Direct 1
vemurafenib, sorafenib PDGFRB Direct 1
axitinib PDGFRB Direct yes 0
becaplermin PDGFRB Direct yes 0
dasatinib PDGFRB Direct yes 0
imatinib PDGFRB Direct yes 0
imatinib mesylate PDGFRB Direct yes 0
midostaurin PDGFRB Direct yes 0
nintedanib esylate PDGFRB Direct yes 0
pazopanib hydrochloride PDGFRB Direct yes 0
sorafenib tosylate PDGFRB Direct yes 0
sunitinib malate PDGFRB Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
afatinib EGFR SSL via EGFR yes 2
dacomitinib EGFR SSL via EGFR yes 2
erlotinib EGFR SSL via EGFR yes 2
gefitinib EGFR SSL via EGFR yes 2
sotorasib KRAS SSL via KRAS yes 2
binimetinib and encorafenib BRAF SSL via BRAF yes 1
lazertinib and amivantamab EGFR SSL via EGFR 1
osimertinib EGFR SSL via EGFR yes 1
sunitinib KDR SSL via KDR yes 5
sunitinib KIT SSL via KIT yes 5
sunitinib PDGFRA SSL via PDGFRA yes 5
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ABL1 SSL via ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FGFR1 SSL via FGFR1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab KDR SSL via KDR 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab KIT SSL via KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab NTRK1 SSL via NTRK1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PDGFRA SSL via PDGFRA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab RAF1 SSL via RAF1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab RET SSL via RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) ABL1 SSL via ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) FGFR1 SSL via FGFR1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) KDR SSL via KDR 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) KIT SSL via KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) NTRK1 SSL via NTRK1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) PDGFRA SSL via PDGFRA 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) RAF1 SSL via RAF1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) RET SSL via RET 4
ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine KDR SSL via KDR 3
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.