Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | RRM1 | Direct | 3 | ||||||||
| gemcitabine | RRM1 | Direct | yes | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | RRM1 | Direct | 3 | ||||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | RRM1 | Direct | 2 | ||||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | RRM1 | Direct | 2 | ||||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | RRM1 | Direct | 2 | ||||||||
| ksq-001ex, interleukin-2, cyclophosphamide, fludarabine | RRM1 | Direct | 2 | ||||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | RRM1 | Direct | 2 | ||||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | RRM1 | Direct | 2 | ||||||||
| nab-paclitaxel, gemcitabine | RRM1 | Direct | 2 | ||||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | RRM1 | Direct | 2 | ||||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | RRM1 | Direct | 2 | ||||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | RRM1 | Direct | 2 | ||||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | RRM1 | Direct | 1 | ||||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | RRM1 | Direct | 1 | ||||||||
| abraxane (nab-paclitaxel), gemcitabine | RRM1 | Direct | 1 | ||||||||
| adct-601, gemcitabine | RRM1 | Direct | 1 | ||||||||
| ag-013736, gemcitabine, gemcitabine, placebo | RRM1 | Direct | 1 | ||||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| ags-1c4d4, gemcitabine | RRM1 | Direct | 1 | ||||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | RRM1 | Direct | 1 | ||||||||
| aldesleukin, biopsy, biospecimen collection, computed tomography, cyclophosphamide, excisional biopsy, fludarabine, magnetic resonance imaging, standard treatment, therapeutic tumor infiltrating lymphocytes | RRM1 | Direct | 1 | ||||||||
| alisertib, gemcitabine | RRM1 | Direct | 1 | ||||||||
| amg 193, gemcitabine, nab-paclitaxel, modified folfirinox | RRM1 | Direct | 1 | ||||||||
| amg 479, placebo, amg 479, gemcitabine | RRM1 | Direct | 1 | ||||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | RRM1 | Direct | 1 | ||||||||
| apg-1387 for injection, gemcitabine, nab paclitaxel | RRM1 | Direct | 1 | ||||||||
| apx005m, nivolumab, nab-paclitaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| arq 197, gemcitabine | RRM1 | Direct | 1 | ||||||||
| ascorbate, nab paclitaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine | RRM1 | Direct | 1 | ||||||||
| atra, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| autologous mesothelin-specific tcr-t cells, cyclophosphamide, fludarabine, bendamustine | RRM1 | Direct | 1 | ||||||||
| avastin (bevacizumab), gemcitabine, radiation therapy | RRM1 | Direct | 1 | ||||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | RRM1 | Direct | 1 | ||||||||
| azd0171, durvalumab, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | RRM1 | Direct | 1 | ||||||||
| azd1775, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | RRM1 | Direct | 1 | ||||||||
| bendamustine, biopsy, biospecimen collection, computed tomography, cyclophosphamide, echocardiography, fludarabine, leukapheresis, magnetic resonance imaging, multigated acquisition scan, positron emission tomography, t-cell receptor-engineered t-cells | RRM1 | Direct | 1 | ||||||||
| bethanechol, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| bevacizumab, erlotinib, gemcitabine | RRM1 | Direct | 1 | ||||||||
| bi 765883, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| biopsy, biospecimen collection, cisplatin, computed tomography, gemcitabine, gemcitabine hydrochloride, magnetic resonance imaging, veliparib | RRM1 | Direct | 1 | ||||||||
| biopsy, biospecimen collection, cisplatin, computed tomography, gemcitabine, magnetic resonance imaging, nab-paclitaxel, pancreatic surgical procedure | RRM1 | Direct | 1 | ||||||||
| biopsy, biospecimen collection, diagnostic imaging, elimusertib, gemcitabine | RRM1 | Direct | 1 | ||||||||
| biospecimen collection, cholestyramine, computed tomography, diagnostic imaging, gemcitabine, leflunomide, magnetic resonance imaging | RRM1 | Direct | 1 | ||||||||
| bms-813160, nivolumab, gemcitabine, nab-paclitaxel, biopsy, peripheral blood | RRM1 | Direct | 1 | ||||||||
| botensilimab, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| busulfan, anti-thymocyte globulin, fludarabine, cyclosporine, mycophenolate mofetil | RRM1 | Direct | 1 | ||||||||
| cadonilimab, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| can04, cisplatin, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed | RRM1 | Direct | 1 | ||||||||
| canakinumab injection; spartalizumab, nab-paclitaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| canakinumab, tislelizumab, nab-paclitaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| capecitabine, cisplatin, epirubicin, gemcitabine | RRM1 | Direct | 1 | ||||||||
| cend-1, gemcitabine, nab paclitaxel | RRM1 | Direct | 1 | ||||||||
| cend-1, nab-paclitaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| cetuximab, capecitabine, oxaliplatin, conventional surgery, radiation therapy, gemcitabine | RRM1 | Direct | 1 | ||||||||
| chemotherapy, cladribine, radiation therapy | RRM1 | Direct | 1 | ||||||||
| chemotherapy, hydroxyurea, pentoxifylline, radiation therapy | RRM1 | Direct | 1 | ||||||||
| cisplatin, capecitabine, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy | RRM1 | Direct | 1 | ||||||||
| cisplatin, gemcitabine, anetumab ravtansine (bay94-9343) | RRM1 | Direct | 1 | ||||||||
| co-1.01, gemcitabine | RRM1 | Direct | 1 | ||||||||
| cpi-613® (dose level -1.0 250 mg/m^2), cpi-613® (dose level 1.0 500 mg/m^2), cpi-613® (dose level 2.0 1,000 mg/m^2), cpi-613® (dose level 3.0 1,500 mg/m^2), cpi-613® maximum tolerated dose (mtd), gemcitabine, intensity-modulated radiation therapy | RRM1 | Direct | 1 | ||||||||
| cyberknife based stereotactic radiotherapy, gemcitabine, fludeoxyglucose (18f) (fdg) | RRM1 | Direct | 1 | ||||||||
| cyclophosphamide, fludarabine, aldesleukin, anti-hcd70 car transduced pbl | RRM1 | Direct | 1 | ||||||||
| cyclophosphamide, fludarabine, mutant kras g12v-specific tcr transduced autologous t cells, anti-pd-1 monoclonal antibody | RRM1 | Direct | 1 | ||||||||
| decitabine, gemcitabine | RRM1 | Direct | 1 | ||||||||
| demcizumab, abraxane®, gemcitabine, placebo | RRM1 | Direct | 1 | ||||||||
| docetaxel, gemcitabine | RRM1 | Direct | 1 | ||||||||
| durvalumab, gemcitabine, nab paclitaxel, tremelimumab, propranolol, cisplatin | RRM1 | Direct | 1 | ||||||||
| durvalumab, gemcitabine, nab-paclitaxel, oleclumab | RRM1 | Direct | 1 | ||||||||
| e7 tcr cells, aldesleukin, fludarabine, cyclophosphamide | RRM1 | Direct | 1 | ||||||||
| electroporation, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| endotag-1, gemcitabine | RRM1 | Direct | 1 | ||||||||
| epacadostat, pembrolizumab, oxaliplatin, leucovorin, 5-fluorouracil, gemcitabine, nab-paclitaxel, carboplatin, paclitaxel, pemetrexed, cyclophosphamide, carboplatin, cisplatin, 5-fluorouracil, investigator's choice of platinum agent | RRM1 | Direct | 1 | ||||||||
| epidermal growth factor receptor(egfrv)iii chimeric antigen receptor (car) transduced pbl, aldesleukin, fludarabine, cyclophosphamide | RRM1 | Direct | 1 | ||||||||
| erlotinib, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| ery001, gemcitabine, 5-fluoro-uracil/oxaliplatin/leucovorin (folfox) | RRM1 | Direct | 1 | ||||||||
| fecal microbiota transplantation, peg3350, gemcitabine, nab-paclitaxel | RRM1 | Direct | 1 | ||||||||
| filgrastim, recombinant interferon alfa, fluorouracil, hydroxyurea | RRM1 | Direct | 1 | ||||||||
| fludarabine, cyclophosphamide, ima101 product, recombinant human interleukin-2, imadetect, atezolizumab | RRM1 | Direct | 1 | ||||||||
| fluorouracil, gemcitabine | RRM1 | Direct | 1 | ||||||||
| fluorouracil, gemcitabine, gemcitabine hydrochloride, leucovorin, leucovorin calcium, liposomal irinotecan, nab-paclitaxel, quality-of-life assessment, questionnaire administration | RRM1 | Direct | 1 | ||||||||
| fluorouracil, gemcitabine, image guided radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, nab-paclitaxel, therapeutic conventional surgery | RRM1 | Direct | 1 | ||||||||
| folfirinox, gemcitabine, radiation therapy, pancreatectomy | RRM1 | Direct | 1 | ||||||||
| folfirinox, lv5fu2, folfiri.3, gemcitabine | RRM1 | Direct | 1 | ||||||||
| ft500, nivolumab, pembrolizumab, atezolizumab, cyclophosphamide, fludarabine, il-2 | RRM1 | Direct | 1 | ||||||||
| galeterone, gemcitabine | RRM1 | Direct | 1 | ||||||||
| gallium maltolate | RRM1 | Direct | 1 | ||||||||
| gb201, paclitaxel, gemcitabine, standard of care treatment options | RRM1 | Direct | 1 | ||||||||
| gemcitabine, abraxane | RRM1 | Direct | 1 | ||||||||
| gemcitabine, abraxane, folfirinox, chemoradiation | RRM1 | Direct | 1 | ||||||||
| gemcitabine, abraxane, hydroxychloroquine | RRM1 | Direct | 1 | ||||||||
| gemcitabine, capecitabine, erlotinib | RRM1 | Direct | 1 | ||||||||
| gemcitabine, capecitabine, stereotactic body radiation therapy (sbrt) | RRM1 | Direct | 1 | ||||||||
| gemcitabine, cp-870,893 | RRM1 | Direct | 1 |