Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 90 of 90 matching drugs for SOD1 — including drugs targeting any of its 131 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
medical cannabis SOD1 Direct 1
nabiximols, temozolomide, nabiximols-matched placebo SOD1 Direct 1
adagrasib KRAS SSL via KRAS yes 2
afatinib EGFR SSL via EGFR yes 2
dacomitinib EGFR SSL via EGFR yes 2
erlotinib EGFR SSL via EGFR yes 2
gefitinib EGFR SSL via EGFR yes 2
sotorasib KRAS SSL via KRAS yes 2
lazertinib and amivantamab EGFR SSL via EGFR 1
osimertinib EGFR SSL via EGFR yes 1
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib CDK4 SSL via CDK4 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib FYN SSL via FYN 3
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone PPARG SSL via PPARG 3
abemaciclib CDK4 SSL via CDK4 yes 2
alvocidib, paclitaxel CDK4 SSL via CDK4 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment FYN SSL via FYN 2
binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib CDK4 SSL via CDK4 2
eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab CDK4 SSL via CDK4 2
palbociclib CDK4 SSL via CDK4 yes 2
abemaciclib, abemaciclib CDK4 SSL via CDK4 1
abemaciclib, bevacizumab CDK4 SSL via CDK4 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf CDK4 SSL via CDK4 1
abemaciclib, ly3023414, gemcitabine, capecitabine CDK4 SSL via CDK4 1
abemaciclib, ly3214996 CDK4 SSL via CDK4 1
abemaciclib, surgery CDK4 SSL via CDK4 1
adjuvant therapy, temozolomide, valproic acid, radiation therapy PPARG SSL via PPARG 1
adriamycin, cyclophosphamide, vindesine, valproic acid PPARG SSL via PPARG 1
afatinib, dasatinib, palbociclib, everolimus, olaparib CDK4 SSL via CDK4 1
afatinib, dasatinib, palbociclib, everolimus, olaparib FYN SSL via FYN 1
alvocidib, docetaxel CDK4 SSL via CDK4 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis CDK4 SSL via CDK4 1
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib CDK4 SSL via CDK4 1
bevacizumab, dasatinib, placebo FYN SSL via FYN 1
biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, palbociclib CDK4 SSL via CDK4 1
blu-222, carboplatin, ribociclib, fulvestrant CDK4 SSL via CDK4 1
byl719, poziotinib, nintedanib, abemaciclib, durvalumab,tremelimumab CDK4 SSL via CDK4 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin TP53 SSL via TP53 1
curcumin PPARG SSL via PPARG 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride FYN SSL via FYN 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method FYN SSL via FYN 1
dasatinib, laboratory biomarker analysis, physiologic testing FYN SSL via FYN 1
dasatinib, mfolfox6 FYN SSL via FYN 1
dasatinib, pharmacological study FYN SSL via FYN 1
dasatinib, temozolomide, placebo, radiation therapy FYN SSL via FYN 1
disulfiram, copper, alkylating agents PRDX1 SSL via PRDX1 1
docetaxel, laboratory biomarker analysis, palbociclib CDK4 SSL via CDK4 1
eras-007, encorafenib, cetuximab, palbociclib CDK4 SSL via CDK4 1
gabapentin, sulfasalazine, memantine, temozolomide, radiotherapy PPARG SSL via PPARG 1
gemcitabine, ribociclib, sonidegib, trametinib, filgrastim CDK4 SSL via CDK4 1
glipizide PPARG SSL via PPARG 1
medical cannabis PPARG SSL via PPARG 1
nabiximols, temozolomide, nabiximols-matched placebo PPARG SSL via PPARG 1
palbociclib, afatinib CDK4 SSL via CDK4 1
palbociclib, gedatolisib CDK4 SSL via CDK4 1
palbociclib, nab-paclitaxel CDK4 SSL via CDK4 1
pioglitazone, pioglitazone PPARG SSL via PPARG 1
ribociclib CDK4 SSL via CDK4 yes 1
ribociclib, everolimus CDK4 SSL via CDK4 1
sorafenib tosylate, valproic acid, sildenafil citrate PPARG SSL via PPARG 1
sulfasalazine PPARG SSL via PPARG 1
trilaciclib CDK4 SSL via CDK4 yes 1
valproic acid PPARG SSL via PPARG 1
valproic acid, bevacizumab, radiation therapy PPARG SSL via PPARG 1
valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine PPARG SSL via PPARG 1
afatinib dimaleate EGFR SSL via EGFR yes 0
balsalazide PPARG SSL via PPARG yes 0
balsalazide disodium PPARG SSL via PPARG yes 0
bezafibrate PPARG SSL via PPARG yes 0
cetuximab EGFR SSL via EGFR yes 0
dasatinib FYN SSL via FYN yes 0
erlotinib hydrochloride EGFR SSL via EGFR yes 0
lapatinib EGFR SSL via EGFR yes 0
lapatinib ditosylate EGFR SSL via EGFR yes 0
mesalamine PPARG SSL via PPARG yes 0
necitumumab EGFR SSL via EGFR yes 0
neratinib EGFR SSL via EGFR yes 0
neratinib maleate EGFR SSL via EGFR yes 0
olsalazine PPARG SSL via PPARG yes 0
olsalazine sodium PPARG SSL via PPARG yes 0
osimertinib mesylate EGFR SSL via EGFR yes 0
panitumumab EGFR SSL via EGFR yes 0
pioglitazone PPARG SSL via PPARG yes 0
pioglitazone hydrochloride PPARG SSL via PPARG yes 0
regorafenib EGFR SSL via EGFR yes 0
ribociclib succinate CDK4 SSL via CDK4 yes 0
rosiglitazone PPARG SSL via PPARG yes 0
rosiglitazone maleate PPARG SSL via PPARG yes 0
troglitazone PPARG SSL via PPARG yes 0
vandetanib EGFR SSL via EGFR yes 0
vandetanib FYN SSL via FYN yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.