Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | TOP1MT | Direct | 3 | ||||||||
| lurbinectedin, irinotecan | TOP1MT | Direct | 3 | ||||||||
| apatinib, irinotecan | TOP1MT | Direct | 2 | ||||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | TOP1MT | Direct | 2 | ||||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | TOP1MT | Direct | 2 | ||||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | TOP1MT | Direct | 2 | ||||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | TOP1MT | Direct | 2 | ||||||||
| irinotecan, capecitabine | TOP1MT | Direct | 2 | ||||||||
| irinotecan, docetaxel | TOP1MT | Direct | 2 | ||||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | TOP1MT | Direct | 2 | ||||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | TOP1MT | Direct | 2 | ||||||||
| topotecan | TOP1MT | Direct | 2 | ||||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | TOP1MT | Direct | 1 | ||||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | TOP1MT | Direct | 1 | ||||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | TOP1MT | Direct | 1 | ||||||||
| afatinib, irinotecan | TOP1MT | Direct | 1 | ||||||||
| aldoxorubicin, topotecan | TOP1MT | Direct | 1 | ||||||||
| amrubicin, topotecan | TOP1MT | Direct | 1 | ||||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | TOP1MT | Direct | 1 | ||||||||
| at-101, topotecan | TOP1MT | Direct | 1 | ||||||||
| avastin, temozolomide, irinotecan | TOP1MT | Direct | 1 | ||||||||
| avastin, temozolomide, radiation therapy (xrt), irinotecan | TOP1MT | Direct | 1 | ||||||||
| avelumab, irinotecan, paclitaxel, best supportive care (bsc) | TOP1MT | Direct | 1 | ||||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | TOP1MT | Direct | 1 | ||||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | TOP1MT | Direct | 1 | ||||||||
| bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil | TOP1MT | Direct | 1 | ||||||||
| berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging | TOP1MT | Direct | 1 | ||||||||
| bevacizumab [avastin], irinotecan, temozolomide | TOP1MT | Direct | 1 | ||||||||
| bevacizumab, irinotecan | TOP1MT | Direct | 1 | ||||||||
| bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging | TOP1MT | Direct | 1 | ||||||||
| bevacizumab, temozolomide, radiation therapy (xrt), topotecan | TOP1MT | Direct | 1 | ||||||||
| bi 764532, topotecan, single agent chemotherapy | TOP1MT | Direct | 1 | ||||||||
| biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin | TOP1MT | Direct | 1 | ||||||||
| biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab | TOP1MT | Direct | 1 | ||||||||
| bl-b01d1, irinotecan, paclitaxel, docetaxel | TOP1MT | Direct | 1 | ||||||||
| bl-b01d1, topotecan | TOP1MT | Direct | 1 | ||||||||
| bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan | TOP1MT | Direct | 1 | ||||||||
| bortezomib, irinotecan | TOP1MT | Direct | 1 | ||||||||
| camrelizumab, docetaxel, irinotecan | TOP1MT | Direct | 1 | ||||||||
| camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib | TOP1MT | Direct | 1 | ||||||||
| capecitabine, oxaliplatin, irinotecan | TOP1MT | Direct | 1 | ||||||||
| carboplatin, irinotecan | TOP1MT | Direct | 1 | ||||||||
| carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study | TOP1MT | Direct | 1 | ||||||||
| cetuximab, bevacizumab, irinotecan | TOP1MT | Direct | 1 | ||||||||
| cetuximab, irinotecan, oxaliplatin, uft | TOP1MT | Direct | 1 | ||||||||
| cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy | TOP1MT | Direct | 1 | ||||||||
| cisplatin, gleevec™, irinotecan | TOP1MT | Direct | 1 | ||||||||
| cisplatin, irinotecan, capecitabine | TOP1MT | Direct | 1 | ||||||||
| digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin | TOP1MT | Direct | 1 | ||||||||
| durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf | TOP1MT | Direct | 1 | ||||||||
| fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery | TOP1MT | Direct | 1 | ||||||||
| fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration | TOP1MT | Direct | 1 | ||||||||
| fluorouracil, oxaliplatin, irinotecan | TOP1MT | Direct | 1 | ||||||||
| gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) | TOP1MT | Direct | 1 | ||||||||
| gemcitabine, taxotere, xeloda, cisplatin, irinotecan | TOP1MT | Direct | 1 | ||||||||
| ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan | TOP1MT | Direct | 1 | ||||||||
| imatinib, irinotecan, carboplatin | TOP1MT | Direct | 1 | ||||||||
| irinotecan hydrochloride liposome injection, topotecan | TOP1MT | Direct | 1 | ||||||||
| irinotecan, 5-fluorouracil, leucovorin | TOP1MT | Direct | 1 | ||||||||
| irinotecan, bevacizumab, fdopa-pet/mri imaging | TOP1MT | Direct | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab | TOP1MT | Direct | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab, radiation | TOP1MT | Direct | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab, radiation therapy | TOP1MT | Direct | 1 | ||||||||
| irinotecan, cisplatin, simvastatin | TOP1MT | Direct | 1 | ||||||||
| irinotecan, ibi343, paclitaxel | TOP1MT | Direct | 1 | ||||||||
| irinotecan, leucovorin, 5-fluorouracil, docetaxel, cisplatin, leucovorin, 5-fluorouracil | TOP1MT | Direct | 1 | ||||||||
| irinotecan, lurbinectedin, irinotecan, topotecan, lurbinectedin | TOP1MT | Direct | 1 | ||||||||
| irinotecan, radiation therapy | TOP1MT | Direct | 1 | ||||||||
| irinotecan, ramucirumab, blood for angiome profiling, blood for cfdna | TOP1MT | Direct | 1 | ||||||||
| kc1036, irinotecan, docetaxel, s-1 | TOP1MT | Direct | 1 | ||||||||
| liposomal irinotecan, 5-fu, lv, irinotecan | TOP1MT | Direct | 1 | ||||||||
| ljm716, byl719, paclitaxel, docetaxel, irinotecan | TOP1MT | Direct | 1 | ||||||||
| lurbinectedin, irinotecan, lurbinectedin, topotecan | TOP1MT | Direct | 1 | ||||||||
| ly3962673, cetuximab, gemcitabine, nab-paclitaxel, oxaliplatin, leucovorin, irinotecan, 5-fluorouracil | TOP1MT | Direct | 1 | ||||||||
| mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan | TOP1MT | Direct | 1 | ||||||||
| nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan, nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan | TOP1MT | Direct | 1 | ||||||||
| nab-paclitaxel, gemcitabine, cisplatin, irinotecan, capecitabine, pembrolizumab, olaparib | TOP1MT | Direct | 1 | ||||||||
| napabucasin, nab-paclitaxel, gemcitabine, nivolumab, paclitaxel, irinotecan, leucovorin, 5fluorouracil, bevacizumab | TOP1MT | Direct | 1 | ||||||||
| np137, oxaliplatin, irinotecan, calcium levofolinate, 5 fu | TOP1MT | Direct | 1 | ||||||||
| olaparib, temozolomide, irinotecan | TOP1MT | Direct | 1 | ||||||||
| oxaliplatin, docetaxel, leucovorin, irinotecan, 5-fluorouracil | TOP1MT | Direct | 1 | ||||||||
| oxaliplatin, irinotecan, 5-fu, gemcitabine, radiation therapy | TOP1MT | Direct | 1 | ||||||||
| oxaliplatin, irinotecan, capecitabine | TOP1MT | Direct | 1 | ||||||||
| oxaliplatin, irinotecan, folinic acid, 5-fluorouracil, gemcitabine, capecitabine | TOP1MT | Direct | 1 | ||||||||
| oxaliplatin, irinotecan, leucovorin, 5-fluorouracil, capecitabine, radiation, surgery, gemcitabine | TOP1MT | Direct | 1 | ||||||||
| oxaliplatin, irinotecan, leucovorin, fluorouracil, laboratory biomarker analysis, flow cytometry, immunohistochemistry staining method, pharmacological study, pf-04136309 | TOP1MT | Direct | 1 | ||||||||
| oxaliplatine, folinic acid, irinotecan, 5-fu | TOP1MT | Direct | 1 | ||||||||
| paclitaxel, irinotecan, pembrolizumab, mk-4830, lenvatinib, sacituzumab tirumotecan, antihistamine, h2 receptor antagonist, acetaminophen (or equivalent), dexamethasone (or equivalent) | TOP1MT | Direct | 1 | ||||||||
| panitumumab, irinotecan | TOP1MT | Direct | 1 | ||||||||
| pd-1 inhibitors, irinotecan, capecitabine tablets | TOP1MT | Direct | 1 | ||||||||
| pegph20, oxaliplatin, leucovorin, irinotecan, 5-fluorouracil | TOP1MT | Direct | 1 | ||||||||
| pembrolizumab, coformulation favezelimab/pembrolizumab, mk-4830, lenvatinib, irinotecan, paclitaxel | TOP1MT | Direct | 1 | ||||||||
| pep02, irinotecan, docetaxel | TOP1MT | Direct | 1 | ||||||||
| pm8002, paclitaxel, topotecan | TOP1MT | Direct | 1 | ||||||||
| regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil | TOP1MT | Direct | 1 | ||||||||
| reolysin®, chemotherapy, gemcitabine, irinotecan, leucovorin, 5-fluorouracil, pembrolizumab | TOP1MT | Direct | 1 | ||||||||
| rmc-6236, gemcitabine, nab-paclitaxel, irinotecan, liposomal irinotecan, 5-fluorouracil, leucovorin, oxaliplatin | TOP1MT | Direct | 1 | ||||||||
| sacituzumab tirumotecan, trifluridine-tipiracil, irinotecan, paclitaxel, docetaxel, rescue medication, supportive care measures | TOP1MT | Direct | 1 | ||||||||
| shr-a1904, paclitaxel, docetaxel, irinotecan | TOP1MT | Direct | 1 | ||||||||
| si-b001, irinotecan | TOP1MT | Direct | 1 |