Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine | TOP2A | Direct | 2 | ||||||||
| adebrelimab injection, apatinib mesylate tablets, carboplatin, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| adebrelimab, apatinib mesylate, etoposide, carboplatin | TOP2A | Direct | 1 | ||||||||
| adebrelimab, carboplatin/cisplatin, etoposide, radiation therapy | TOP2A | Direct | 1 | ||||||||
| adebrelimab, radiation therapy, etoposide, carboplatin(ec) | TOP2A | Direct | 1 | ||||||||
| aldoxorubicin, topotecan | TOP2A | Direct | 1 | ||||||||
| amifostine trihydrate, cisplatin, etoposide, radiation therapy | TOP2A | Direct | 1 | ||||||||
| amrubicin | TOP2A | Direct | 1 | ||||||||
| amrubicin, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| amrubicin, topotecan | TOP2A | Direct | 1 | ||||||||
| anti-igf-1r recombinant monoclonal antibody mk-0646, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| atezolizumab, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| autologous dendritic cell-adenovirus p53 vaccine, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| becatecarin | TOP2A | Direct | 1 | ||||||||
| belinostat, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| belotecan, etoposide, cisplatin | TOP2A | Direct | 1 | ||||||||
| bevacizumab, cisplatin, etoposide, radiation therapy | TOP2A | Direct | 1 | ||||||||
| bi 764532, carboplatin, etoposide, atezolizumab, durvalumab, cisplatin | TOP2A | Direct | 1 | ||||||||
| biopsy, folfirinox, ciprofloxacin, metronidazole, pembrolizumab, surgical resection | TOP2A | Direct | 1 | ||||||||
| bms-833923, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| bms-986012, carboplatin, etoposide, nivolumab | TOP2A | Direct | 1 | ||||||||
| bms-986012, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| bms-986012, cisplatin, etoposide, platinum, carboplatin | TOP2A | Direct | 1 | ||||||||
| bms-986489 (bms-986012+nivolumab), atezolizumab, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan | TOP2A | Direct | 1 | ||||||||
| capecitabine, carboplatin, cisplatin, etoposide, laboratory biomarker analysis, temozolomide | TOP2A | Direct | 1 | ||||||||
| capecitabine, cisplatin, epirubicin, gemcitabine | TOP2A | Direct | 1 | ||||||||
| capecitabine, epirubicin, amg 102, cisplatin, placebo | TOP2A | Direct | 1 | ||||||||
| carboplatin, atezolizumab, etoposide, total body irradiation, hypofractionated radiation therapy, magnetic resonance imaging | TOP2A | Direct | 1 | ||||||||
| carboplatin, cisplatin, cyclophosphamide, doxorubicin hydrochloride, etoposide, ifosfamide, mesna, vincristine sulfate, radiation therapy | TOP2A | Direct | 1 | ||||||||
| carboplatin, cisplatin, docetaxel, etoposide, pembrolizumab | TOP2A | Direct | 1 | ||||||||
| carboplatin, cisplatin, etoposide, irinotecan hydrochloride, radiation therapy | TOP2A | Direct | 1 | ||||||||
| carboplatin, cisplatin, etoposide, sintilimab, ibi110 | TOP2A | Direct | 1 | ||||||||
| carboplatin, etoposide, ifosfamide, topotecan hydrochloride, radiation therapy | TOP2A | Direct | 1 | ||||||||
| carboplatin, etoposide, topotecan hydrochloride, radiation therapy | TOP2A | Direct | 1 | ||||||||
| carmustine, chemotherapy, cisplatin, etoposide, radiation therapy | TOP2A | Direct | 1 | ||||||||
| carmustine, cisplatin, etoposide, radiation therapy | TOP2A | Direct | 1 | ||||||||
| celecoxib, cyclophosphamide, etoposide, thalidomide | TOP2A | Direct | 1 | ||||||||
| cis platinum, etoposide, s1 | TOP2A | Direct | 1 | ||||||||
| cisplatin, carboplatin, etoposide, durvalumab, ceralasertib | TOP2A | Direct | 1 | ||||||||
| cisplatin, carboplatin, etoposide, pembrolizumab, computed tomography, positron emission tomography, magnetic resonance imaging, biospecimen collection, radiation therapy | TOP2A | Direct | 1 | ||||||||
| cisplatin, cyclophosphamide, etoposide | TOP2A | Direct | 1 | ||||||||
| cisplatin, etoposide, bevacizumab, laboratory biomarker analysis | TOP2A | Direct | 1 | ||||||||
| cisplatin, etoposide, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| cisplatin, etoposide, radiation therapy | TOP2A | Direct | 1 | ||||||||
| cisplatin, etoposide, tirapazamine, radiation therapy | TOP2A | Direct | 1 | ||||||||
| debio 0123, etoposide, carboplatin | TOP2A | Direct | 1 | ||||||||
| doxorubicin, cisplatin, 5-fluorouracil | TOP2A | Direct | 1 | ||||||||
| durvalumab, carboplatin, etoposide, thoracic radiotherapy | TOP2A | Direct | 1 | ||||||||
| durvalumab, cisplatin, etoposide, carboplatin | TOP2A | Direct | 1 | ||||||||
| durvalumab, monalizumab, carboplatin or cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| epirubicin, capecitabine, cisplatin, surgical resection | TOP2A | Direct | 1 | ||||||||
| epirubicin, cisplatin / oxaliplatin, 5 flourouracil/ capecitabine, (41.4 gy/23 fractions), paclitaxel, carboplatin, docetaxel, oxaliplatin, leucovorin, 5-fluorouracil | TOP2A | Direct | 1 | ||||||||
| epirubicin, cisplatin, 5-fluorouracil (5-fu), radiation | TOP2A | Direct | 1 | ||||||||
| epirubicin, cisplatin, capecitabine, bevacizumab, docetaxel and irinotecan | TOP2A | Direct | 1 | ||||||||
| epirubicin, cisplatin, capecitabine, surgical resection | TOP2A | Direct | 1 | ||||||||
| epirubicin, oxaliplatin, capecitabine, zolbetuximab | TOP2A | Direct | 1 | ||||||||
| etoposide, cisplatin, carboplatin, adebrelimab, radiotherapy | TOP2A | Direct | 1 | ||||||||
| filgrastim, amifostine trihydrate, cisplatin, etoposide, paclitaxel, topotecan hydrochloride, radiation therapy | TOP2A | Direct | 1 | ||||||||
| filgrastim, busulfan, cyclophosphamide, etoposide, melphalan, autologous-autologous tandem hematopoietic stem cell transplantation, radiation therapy | TOP2A | Direct | 1 | ||||||||
| filgrastim, carboplatin, cisplatin, cyclophosphamide, etoposide, thiotepa, vincristine sulfate, conventional surgery, peripheral blood stem cell transplantation | TOP2A | Direct | 1 | ||||||||
| filgrastim, carboplatin, cyclophosphamide, etoposide, autologous bone marrow transplantation, peripheral blood stem cell transplantation | TOP2A | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, bone marrow ablation with stem cell support, peripheral blood stem cell transplantation | TOP2A | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, ifosfamide, in vitro-treated peripheral blood stem cell transplantation | TOP2A | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, isotretinoin, thiotepa, autologous bone marrow transplantation, peripheral blood stem cell transplantation | TOP2A | Direct | 1 | ||||||||
| filgrastim, carboplatin, etoposide, paclitaxel, topotecan hydrochloride, radiation therapy | TOP2A | Direct | 1 | ||||||||
| gemcitabine, vinorelbine, cisplatin, etoposide, carboplatin | TOP2A | Direct | 1 | ||||||||
| genistein, erlotinib hydrochloride, gemcitabine hydrochloride | TOP2A | Direct | 1 | ||||||||
| ibrutinib, indoximod, cyclophosphamide, etoposide | TOP2A | Direct | 1 | ||||||||
| in10018, tislelizumab, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| indoximod, partial radiation, full-dose radiation, temozolomide, cyclophosphamide, etoposide, lomustine | TOP2A | Direct | 1 | ||||||||
| indoximod, temozolomide, conformal radiation, cyclophosphamide, etoposide | TOP2A | Direct | 1 | ||||||||
| m9466, carboplatin, etoposide, atezolizumab, m9446, m9446, carboplatin | TOP2A | Direct | 1 | ||||||||
| matuzumab, epirubicin, cisplatin, capecitabine | TOP2A | Direct | 1 | ||||||||
| mri-guided laser heat ablation (mla), doxorubicin, blood draw - dendritic cells, dynamic susceptibility contrast magnetic resonance imaging | TOP2A | Direct | 1 | ||||||||
| ngr-htnf, doxorubicin | TOP2A | Direct | 1 | ||||||||
| pegylated recombinant human arginase i, doxorubicin | TOP2A | Direct | 1 | ||||||||
| pm8002, platinum, atezolizumab, etoposide | TOP2A | Direct | 1 | ||||||||
| r-(-)-gossypol acetic acid, cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| radiotherapy, temozolomide, doxorubicin | TOP2A | Direct | 1 | ||||||||
| rta 744, rta 744 injection | TOP2A | Direct | 1 | ||||||||
| ryz101 dose level 1, ryz101 dose level 2, ryz101 dose level 3, ryz101 dose level -1, atezolizumab, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| serplulimab, lurbinectedin, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| shr1316, carboplatin, etoposide, radiation therapy, cisplatin | TOP2A | Direct | 1 | ||||||||
| tamoxifen, etoposide | TOP2A | Direct | 1 | ||||||||
| tarlatamab, carboplatin, etoposide, atezolizumab, durvalumab | TOP2A | Direct | 1 | ||||||||
| tarlatamab, lurbinectedin, topotecan, amrubicin | TOP2A | Direct | 1 | ||||||||
| tiragolumab, atezolizumab, carboplatin, etoposide, tiragolumab matching placebo | TOP2A | Direct | 1 | ||||||||
| tislelizumab, carboplatin /cisplatin, etoposide, carboplatin / cisplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| tislelizumab, etoposide, carboplatin or cisplatin, thoracic radiotherapy | TOP2A | Direct | 1 | ||||||||
| zkab001, placebo, carboplatin, etoposide | TOP2A | Direct | 1 | ||||||||
| amsacrine | TOP2A | Direct | yes | 0 | |||||||
| daunorubicin | TOP2A | Direct | yes | 0 | |||||||
| daunorubicin citrate | TOP2A | Direct | yes | 0 | |||||||
| daunorubicin hydrochloride | TOP2A | Direct | yes | 0 | |||||||
| doxorubicin | TOP2A | Direct | yes | 0 | |||||||
| doxorubicin hydrochloride | TOP2A | Direct | yes | 0 | |||||||
| etoposide | TOP2A | Direct | yes | 0 | |||||||
| etoposide phosphate | TOP2A | Direct | yes | 0 | |||||||
| idarubicin | TOP2A | Direct | yes | 0 |