Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 2068 matching drugs for TYMS — including drugs targeting any of its 201 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine TYMS Direct 3
capecitabine, cisplatin TYMS Direct 3
gemcitabine TYMS Direct 3
srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab TYMS Direct 3
5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin TYMS Direct 2
ab598, zimberelimab, fluorouracil, leucovorin, oxaliplatin TYMS Direct 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel TYMS Direct 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan TYMS Direct 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine TYMS Direct 2
avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 TYMS Direct 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment TYMS Direct 2
bevacizumab, oxaliplatin, leucovorin calcium, fluorouracil, therapeutic conventional surgery, laboratory biomarker analysis TYMS Direct 2
biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging TYMS Direct 2
biospecimen collection, computed tomography, pemetrexed TYMS Direct 2
capecitabine TYMS Direct yes 2
capecitabine, carboplatin, epirubicin hydrochloride TYMS Direct 2
capecitabine, docetaxel TYMS Direct 2
capecitabine, irinotecan hydrochloride TYMS Direct 2
capecitabine, oxaliplatin TYMS Direct 2
capecitabine, oxaliplatin, gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction, adjuvant therapy, biopsy, conventional surgery, neoadjuvant therapy, quality-of-life assessment, radiation therapy TYMS Direct 2
capecitabine, temozolomide TYMS Direct 2
carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy TYMS Direct 2
cetuximab, cisplatin, fluorouracil, conventional surgery TYMS Direct 2
chemotherapy, cisplatin, fluorouracil, low-let electron therapy, low-let photon therapy TYMS Direct 2
cisplatin, fluorouracil, conventional surgery, neoadjuvant therapy, radiation therapy TYMS Direct 2
cisplatin, fluorouracil, iressa, conventional surgery, radiation therapy TYMS Direct 2
cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy TYMS Direct 2
cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy TYMS Direct 2
cisplatin, fluorouracil, surgical procedure, radiation therapy TYMS Direct 2
cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab TYMS Direct 2
durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel TYMS Direct 2
erlotinib hydrochloride, oxaliplatin, fluorouracil, radiation therapy, conventional surgery, immunohistochemistry staining method, positron emission tomography, computed tomography, laboratory biomarker analysis, gene expression analysis, fludeoxyglucose f 18 TYMS Direct 2
filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy TYMS Direct 2
filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy TYMS Direct 2
fluorouracil, gemcitabine hydrochloride, leucovorin calcium TYMS Direct 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, pharmacogenomic studies, pharmacological study TYMS Direct 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study TYMS Direct 2
fluorouracil, oxaliplatin, conventional surgery, radiation therapy TYMS Direct 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide TYMS Direct 2
ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib TYMS Direct 2
irinotecan, capecitabine TYMS Direct 2
laboratory biomarker analysis, oxaliplatin, pralatrexate TYMS Direct 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab TYMS Direct 2
m6620, cisplatin, capecitabine, radiotherapy TYMS Direct 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed TYMS Direct 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a TYMS Direct 2
nab-paclitaxel, gemcitabine TYMS Direct 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine TYMS Direct 2
oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu TYMS Direct 2
oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, laboratory biomarker analysis TYMS Direct 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu TYMS Direct 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin TYMS Direct 2
pemetrexed, bevacizumab TYMS Direct 2
pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography TYMS Direct 2
sar444881, pembrolizumab, cetuximab, carboplatin, pemetrexed TYMS Direct 2
sy-5609, fulvestrant, gemcitabine, nab-paclitaxel TYMS Direct 2
tislelizumab, pemetrexed TYMS Direct 2
whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy TYMS Direct 2
3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy TYMS Direct 1
3-dimensional conformal radiation therapy, biospecimen collection, capecitabine, chemotherapy, computed tomography, erlotinib hydrochloride, fluorouracil, gemcitabine hydrochloride, intensity-modulated radiation therapy, magnetic resonance imaging, quality-of-life assessment, x-ray imaging TYMS Direct 1
4-dimensional computed tomography, fluorouracil, gemcitabine hydrochloride, laboratory biomarker analysis, leucovorin calcium, nelfinavir mesylate, oregovomab, stereotactic body radiation therapy, therapeutic conventional surgery TYMS Direct 1
6,8-bis(benzylthio)octanoic acid, oxaliplatin, leucovorin calcium, irinotecan hydrochloride, fluorouracil, laboratory biomarker analysis TYMS Direct 1
7-hydroxystaurosporine, fluorouracil TYMS Direct 1
9-ing-41, retifanlimab, gemcitabine, abraxane TYMS Direct 1
abbv-400, budigalimab, fluorouracil, leucovorin, oxaliplatin TYMS Direct 1
abemaciclib, ly3023414, gemcitabine, capecitabine TYMS Direct 1
abraxane (nab-paclitaxel), gemcitabine TYMS Direct 1
adct-601, gemcitabine TYMS Direct 1
adebrelimab, apatinib, tegafur TYMS Direct 1
afatinib dimaleate, capecitabine, laboratory biomarker analysis TYMS Direct 1
ag-013736, gemcitabine, gemcitabine, placebo TYMS Direct 1
agen1423, botensilimab, gemcitabine, nab-paclitaxel TYMS Direct 1
ags-1c4d4, gemcitabine TYMS Direct 1
ak104, ak104, gemcitabine, nab-paclitaxel TYMS Direct 1
ak104, oxaliplatin, capecitabine TYMS Direct 1
ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine TYMS Direct 1
akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib TYMS Direct 1
albumin-bound paclitaxel (abi-007), gemcitabine TYMS Direct 1
aldesleukin, antibody therapy, fluorouracil, gemcitabine hydrochloride, irinotecan hydrochloride, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel albumin-stabilized nanoparticle formulation, sargramostim TYMS Direct 1
alisertib, gemcitabine TYMS Direct 1
amg 193, gemcitabine, nab-paclitaxel, modified folfirinox TYMS Direct 1
amg 386 placebo, amg 386 10mg/kg, amg 386 3mg/kg, cisplatin, capecitabine, cisplatin, capecitabine, cisplatin, capecitabine TYMS Direct 1
amg 479, placebo, amg 479, gemcitabine TYMS Direct 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel TYMS Direct 1
apg-1387 for injection, gemcitabine, nab paclitaxel TYMS Direct 1
aprepitant, gemcitabine hydrochloride, capecitabine, fluorouracil, radiation therapy, questionnaire administration, quality-of-life assessment, nausea and vomiting therapy, management of therapy complications TYMS Direct 1
apx005m, nivolumab, nab-paclitaxel, gemcitabine TYMS Direct 1
arq 197, gemcitabine TYMS Direct 1
ascorbate, nab paclitaxel, gemcitabine TYMS Direct 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine TYMS Direct 1
askb589, oxaliplatin, capecitabine, tislelizumab, placebo TYMS Direct 1
atezolizumab, biospecimen collection, capecitabine, computed tomography, docetaxel, echocardiography, fluorouracil, leucovorin calcium, lymphadenectomy, magnetic resonance imaging, oxaliplatin, positron emission tomography, surgical procedure TYMS Direct 1
atezolizumab, conventional surgery, fluorouracil, oxaliplatin, tiragolumab TYMS Direct 1
atra, gemcitabine, nab-paclitaxel TYMS Direct 1
avastin (bevacizumab), gemcitabine, radiation therapy TYMS Direct 1
avelumab, oxaliplatin, 5-fluorouracil, leucovorin, capecitabine, best supportive care, oxaliplatin, 5-fluorouracil, leucovorin, capecitabine TYMS Direct 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab TYMS Direct 1
azd0171, durvalumab, gemcitabine, nab-paclitaxel TYMS Direct 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine TYMS Direct 1
azd1775, gemcitabine, nab-paclitaxel TYMS Direct 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.