Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage
Homotetramer
A form of bone marrow failure syndrome, a heterogeneous group of life-threatening disorders characterized by hematopoietic defects in association with a range of variable extra-hematopoietic manifestations. AMEDS is an autosomal recessive, digenic form characterized by childhood onset of bone marrow failure resulting in aplastic anemia, in association with global developmental delay, intellectual disability, and poor overall growth with short stature.
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to ALDH2, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 7
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT02309801 | Healthy | Interaction Between a Natural Aldehyde Dehydrogenase 2 (ALDH2) Inhibitor and Alcohol | PHASE1 | COMPLETED |
| NCT04270201 | Oral Squamous Cell Carcinoma (OSCC) | Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population | N/A | UNKNOWN |
| NCT05524142 | Atrial Fibrillation | Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation | N/A | UNKNOWN |
| NCT02630212 | Aortic Dissection | The Relationship Between ALDH2 and Aortic Dissection | N/A | UNKNOWN |
| NCT07273279 | Condition/Disease, Lung Cancer (Diagnosis), Lung Adenocarcinoma | ADH1B and ALDH Gene Variants and Lung Cancer Risk | N/A | NOT_YET_RECRUITING |
| NCT00661141 | Aldehyde Dehydrogenase-2 (ALDH2) Deficiency | Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism | PHASE2 | COMPLETED |
| NCT03762538 | Propofol | The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness | N/A | UNKNOWN |
| NCT06475781 | Group 3 Pulmonary Hypertension | Study to Evaluate Safety and Efficacy of Mirivadelgat in PH-ILD | PHASE2 | RECRUITING |
| NCT03780738 | Aortic Dissection | A Validation Study of The Relationship Between ALDH2 and Aortic Dissection | N/A | UNKNOWN |
| NCT02643706 | Radiographic Contrast Agent Nephropathy | Relationship Between ALDH2 and CIN | N/A | UNKNOWN |