Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806).
Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013)
Liver
A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to APOC3, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 18
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT06784349 | Dyslipidemia | ALN-APOC3 in Adult Participants With Dyslipidemia | PHASE1 | COMPLETED |
| NCT01682655 | Fatty Liver, Obesity | Genetic Variant in Apolipoprotein C3 Gene and Fatty Liver in Obese Children | N/A | COMPLETED |
| NCT04419688 | Hypertriglyceridemia | A First in Human Study of STT-5058, an Antibody That Binds ApoC3 | PHASE1 | TERMINATED |
| NCT04720534 | Severe Hypertriglyceridemia | Study to Evaluate ARO-APOC3 in Adults With Severe Hypertriglyceridemia | PHASE2 | COMPLETED |
| NCT07176923 | Familial Chylomicronemia Syndrome (FCS) | CS-121 APOC3 Base Editing in FCS | EARLY_PHASE1 | RECRUITING |
| NCT05079919 | Severe Hypertriglyceridemia | A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia | PHASE3 | COMPLETED |
| NCT05902598 | Familial Chylomicronemia Syndrome | A Phase 3 Study of ARO-APOC3 / VSA001 / SAR449124 (Plozasiran) in Chinese Adults With Familial Chylomicronemia Syndrome | PHASE3 | COMPLETED |
| NCT04998201 | Mixed Dyslipidemia | Study of Plozasiran (ARO-APOC3) in Adults With Mixed Dyslipidemia | PHASE2 | COMPLETED |
| NCT03783377 | Hypertriglyceridemia, Familial Chylomicronemia | Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS) | PHASE1 | COMPLETED |
| NCT02083510 | Hypertriglyceridemia, Gout, Pericarditis | Apolipoprotein CIII Reduction Via Colchicine | EARLY_PHASE1 | COMPLETED |