Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A (PubMed:17446437, PubMed:24465725). Does not act as a receptor for angiotensin-2 (PubMed:17446437). Does not bind the VEGFA mature protein (By similarity).
May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity)
Expressed in kidney (PubMed:17446437). Expressed in endothelial cells (PubMed:24465725)
| Cancer Type | Mutation Percentage |
|---|---|
| Central Nervous System Astrocytoma Grade Iv | 0.95% |
| Lung Adenocarcinoma | 2.09% |
| Lung Small Cell Carcinoma | 2.37% |
| Lung Squamous Cell Carcinoma | 4.08% |
| Oesophagus Adenocarcinoma | 1.24% |
| Oesophagus Squamous Cell Carcinoma | 4.81% |
| Pancreas Ductal Carcinoma | 1.79% |
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to FBXW7, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 15
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT02873975 | Advanced Cancers | A Study of LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency | PHASE2 | COMPLETED |