Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B.
Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes.
Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling.
Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization.
Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity)
Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated).
Interacts with PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1.
Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation. Interacts with PIK3R1 and FASLG (By similarity). Interacts with CLNK (By similarity)
Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to FGR, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 4
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT04228627 | Iron Deficiency (Without Anemia), Pregnancy Related | Ferritin Screening And IRon Treatment for Maternal Anemia and FGR Prevention Trial | PHASE4 | COMPLETED |
| NCT06104748 | MVM-FGR | A Cohort of Maternal Vascular Malperfusion-related FGR (CoMVMFGR) | N/A | RECRUITING |
| NCT05601375 | Speckle Tracking, Fetus Fetus, Neonate, Structural Heart Disease, Fetal Growth Restriction | Speckle Tracking Echocardiography in Infants, Prenatally and Postnatally | N/A | UNKNOWN |
| NCT07549295 | Fetal Growth Restriction (FGR) | Melatonin and Perinatal Outcomes in MVM-Related Fetal Growth Restriction (MIMVMFGR) | PHASE1 | ENROLLING_BY_INVITATION |
| NCT07152106 | Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset, Neonatal Sepsis, Late-Onset, Fetal Growth Restriction (FGR), Preterm Birth Complication, Prematurity Complications | Amniotic Fluid & the Preterm Gut | N/A | RECRUITING |
| NCT06893926 | s100b, Hypoxia-Ischemia, Brain, Fetal Growth Restriction (FGR) | Cord Blood S100B Protein Concentration in Neonates With Fetal Growth Restriction | N/A | RECRUITING |
| NCT04447248 | Late-onset Fetal Growth Restriction | qCTG and Doppler Ultrasound in the Detection of Hypoxia Among FGR Fetuses | N/A | COMPLETED |
| NCT05837195 | Hypoxia, Anemia | Diastolic Deceleration Area in Late-onset FGR | N/A | UNKNOWN |
| NCT07473739 | Fetal Growth Restriction (FGR) | AI-Based Ultrasound Prediction of Pregnancy Outcomes in Placental-Related Fetal Growth Restriction (MVM-FGR): A Prospective Cohort Study | N/A | RECRUITING |
| NCT05034861 | Fetal Growth Restriction | COmputerized CTG Self-MOnitoring Versus Standard Doppler Assessment in Late-onset FGR: COSMOS Study | NA | UNKNOWN |