Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity).
In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility (PubMed:11437381). Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons (PubMed:11004567, PubMed:3352745). Released by lectin-stimulated T-cells to induce immunoglobulin secretion (PubMed:11004567, PubMed:3352745)
Homodimer; in the catalytically active form (PubMed:11371164, PubMed:12054796, PubMed:12777791). Monomer in the secreted form (PubMed:11371164, PubMed:12054796, PubMed:12777791)
An autosomal recessive form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency.
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to GPI, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 40
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT04255719 | Parkinson Disease, Deep Brain Stimulation, Globus Pallidus Interna, Subthalamic Nucleus | Unilateral GPi vs Unilateral STN DBS in the Same Patient With PD | NA | COMPLETED |
| NCT07092995 | Parkinson&Amp;#39;s Disease, Freezing of Gait, Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease | Understanding Freezing of Gait Using Brain Signals and Virtual Reality | NA | ENROLLING_BY_INVITATION |
| NCT00090376 | Impotence, Prostate Cancer | Evaluate the Effects of GPI 1485 on Erectile Function Following Bilateral Nerve-Sparing Prostatectomy | PHASE2 | COMPLETED |
| NCT00360009 | Parkinson Disease | Effects of Deep Brain Stimulation on Motor, Mood, and Cognitive Symptoms in Parkinson's Disease | NA | COMPLETED |
| NCT04618887 | Meige Syndrome, Meigs Syndrome, Meige Disease, Meig Syndrome, Blepharospasm, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid, Blepharospasm of Both Eyelids, Blepharospasm Oromandibular Dystonia | A Comparative Study of GPI's DBS and Pallidotomy in the Treatment of Meige Syndrome | N/A | UNKNOWN |
| NCT07130162 | Breast Cancer | Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein in Breast Cancer | N/A | NOT_YET_RECRUITING |
| NCT00108511 | Hypertriglyceridemia | Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides | PHASE1 | COMPLETED |
| NCT00331669 | Dystonia, Movement Disorder | Efficacy and Safety of Deep Brain Stimulation (DBS) of the Pallidal (GPi) in Patients With Tardive Dystonia | PHASE2 | UNKNOWN |
| NCT01870518 | Parkinson's Disease, Mild Cognitive Impairment, Dementia | Neurocognitive Effects of Bilateral STN Versus GPi DBS in Parkinson's Disease Patients With MCI | NA | TERMINATED |
| NCT02438033 | Parkinson's Disease | Characterizing the Specificity and Stability of Local Field Potentials in the Globus Pallidus Internus of Patients Undergoing Deep Brain Stimulation for Parkinson's Disease | PHASE1 | WITHDRAWN |