HTR3C

5-hydroxytryptamine receptor 3C • UniProt accession Q8WXA8

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons

Source: UniProt

Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3A. The homomeric complex is not functional. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo

Source: UniProt
Postsynaptic cell membrane — Multi-pass membrane protein, Cell membrane — Multi-pass membrane protein
Source: UniProt

Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney

Source: UniProt

The HA-stretch region of HTR3C seems to confer increased conductance to HTR3A/HTR3C heteropentamers compared to that of HTR3A homopentamers

Source: UniProt
  • Neurotransmitter receptors and postsynaptic signal transmission
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to HTR3C, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.