HTR4

5-hydroxytryptamine receptor 4 • UniProt accession Q13639

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed:9603189). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:16102731, PubMed:35714614). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:16102731, PubMed:35714614)

Source: UniProt

Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin)

Interacts with MAGI2, MPP3, NHERF1 and SNX27 isoforms 1 and 2 (By similarity). Forms a complex including NHERF1 and EZR (By similarity)

Interacts with PATJ, NOS1 and SEC23A

Source: UniProt
Cell membrane — Multi-pass membrane protein, Endosome membrane — Multi-pass membrane protein
Source: UniProt

Expressed in ileum, brain, and atrium, but not in the ventricle

Mainly expressed in atria and cardiac ventricle

Expressed in all cardiovascular tissues analyzed

Source: UniProt

Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6)

Source: UniProt
  • Serotonin receptors
  • G alpha (s) signalling events
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to HTR4, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.