Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity).
As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109)
Homodimer (PubMed:10074942, PubMed:10409685). Interacts with NHERF1 (PubMed:12080081). Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112).
Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (PubMed:25417112). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:21199876). Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876).
Forms a complex with ASL, ASS1 and HSP90AA1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305)
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to NANOS2, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 40
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT00242853 | Rheumatoid Arthritis, Osteoarthritis | A Study To Investigate Markers Of Inflammation In Rheumatoid Arthritis | N/A | COMPLETED |
| NCT01371929 | Sepsis, Severe Sepsis, Septic Shock | Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study | N/A | TERMINATED |
| NCT02151552 | Lung Inflammation | Assessing NOS Uptake With PET Imaging in Lung Inflammation | EARLY_PHASE1 | COMPLETED |
| NCT01407796 | Pneumonia | PET Imaging of Endotoxin-induced iNOS Activation | PHASE1 | COMPLETED |
| NCT01605695 | Normal Human Plasma Level of iNOS | Normal Human Plasma Level of iNOS Study | N/A | COMPLETED |
| NCT06803836 | Periodontitis, Type 2 Diabetes, Glycemic Control | Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients | N/A | COMPLETED |