Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element
Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4.
Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with CRY1 (By similarity).
Interacts with CRY2 in a ligand-dependent manner (By similarity)
Predominantly expressed in liver
Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to NR1I3, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
No clinical trials information available.