ORM1

Alpha-1-acid glycoprotein 1 UniProt accession P02763

Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body.

Appears to function in modulating the activity of the immune system during the acute-phase reaction

Source: UniProt
Secreted
Source: UniProt

Expressed by the liver and secreted in plasma

Source: UniProt

Contains a beta-barrel that binds various ligands in its interior

Source: UniProt
  • Platelet degranulation
  • Neutrophil degranulation
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to ORM1, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

Total Trials Found: 3

NCT ID Condition Brief Title Phase Status
NCT01812473 Focus of the Study:Protein Binding Characteristics of Voriconazole. Plasma Protein Binding Characteristics of Voriconazole N/A COMPLETED
NCT04532021 Preterm Premature Rupture of Membranes Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 Levels in PPROM N/A UNKNOWN
NCT01838525 Systemic Inflammatory Response Syndrome, Sepsis Alpha-1-acid Glycoprotein as a Biomarker of Developmental Diagnosing and Monitoring Effectiveness in Sepsis N/A UNKNOWN