HPGD

6-phosphogluconate dehydrogenase, decarboxylating UniProt accession P52209

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

Source: UniProt

Homodimer

Source: UniProt
Cytoplasm
Source: UniProt
  • Pentose phosphate pathway
  • NFE2L2 regulates pentose phosphate pathway genes
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to HPGD, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

Total Trials Found: 43

NCT ID Condition Brief Title Phase Status
NCT06084377 Females Undergoing PGD Technology for Medical Conditions Isolation of Cell Free Fetal DNA From Spent Culture Medium and Its Potential Role for Preimplantation Genetic Diagnosis (PGD). N/A COMPLETED
NCT01852331 Schizophrenia, Schizophrenic Disorder, Hyperprolactinemia, Hyperprolactinaemia Peony-Glycyrrhiza Decoction (PGD) for Antipsychotic-induced Hyperprolactinemia in Patients With Schizophrenia PHASE2 COMPLETED
NCT06605326 Pulmonary Hypertension, Pulmonary Arterial Hypertension, Chronic Lung Disease-Associated Pulmonary Hypertension, Lung Transplantation, Heart Failure Subcutaneous Treprostinil as a Bridge to Lung Transplantation in Severe Pulmonary Hypertension: A Single-Arm Retrospective Study PHASE4 COMPLETED
NCT00646893 Infertility Preimplantation Genetic Diagnosis for the Indication of Advanced Reproductive Age PHASE4 SUSPENDED
NCT05365139 Prolonged Grief Disorder Diagnostic Tools for Identifying Prolonged Grief N/A COMPLETED
NCT03208595 Endometrial Flora Characterization in Infertile Women Endometrial Flora in Women Undergoing IVF Treatments N/A UNKNOWN
NCT02133950 Clinical Pregnancy, Live Birth Efficacy Study of Segmentation of PGD Treatment NA UNKNOWN
NCT07487233 Physicians' Knowledge and Diagnostic Practices for PGD in Older Adults, Effect of Brief Training on PGD Diagnosis Prolonged Grief Disorder (PGD) Diagnosis in Older Adults: Physicians' Knowledge and Practice NA NOT_YET_RECRUITING
NCT01332643 Infertility, Miscarriage Preimplantation Genetic Diagnosis (PGD) by Array Comparative Genome Hybridization (CGH) and Blastocyst Biopsy PHASE3 TERMINATED
NCT04376385 Grief An Internet-based Self Applied Treatment Program for Prolonged Grief Disorder (PGD) NA COMPLETED