PTPRD

Tumour Suppressor
Receptor-type tyrosine-protein phosphatase delta • UniProt accession P23468

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2

Source: UniProt

Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:9624153). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats). Interacts with SLITRK2; induces presynaptic differentiation.

Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity)

Source: UniProt
Membrane — Single-pass type I membrane protein
Source: UniProt
  • Receptor-type tyrosine-protein phosphatases
  • Synaptic adhesion-like molecules
Source: Reactome via UniProt

Mutations

Cancer Type Mutation Percentage
Central Nervous System Astrocytoma Grade Iv 0.95%
Lung Adenocarcinoma 13.53%
Lung Small Cell Carcinoma 6.23%
Lung Squamous Cell Carcinoma 7.07%
Oesophagus Adenocarcinoma 26.32%
Oesophagus Squamous Cell Carcinoma 3.87%
Pancreas Ductal Carcinoma 4.47%

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to PTPRD, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.