RXRB

Retinoic acid receptor RXR-beta • UniProt accession P28702

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)

Source: UniProt

Homodimer (in vitro) (PubMed:11782480). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:1310259).

Interacts with NR1H3 (PubMed:12970175). Interacts with AKAP13 (By similarity)

Source: UniProt
Nucleus, Cytoplasm
Source: UniProt

Expressed in aortic endothelial cells (at protein level) (PubMed:28167758). Expressed in monocytes (PubMed:26463675). Expressed in a variety of tumor cell lines

Source: UniProt

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain

Source: UniProt
  • PPARA activates gene expression
  • Nuclear Receptor transcription pathway
  • Signaling by Retinoic Acid
  • NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
  • NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
  • NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
  • NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to RXRB, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.