Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748).
Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189)
Identified in a complex with STOM
Expressed in testis at the blood-testis barrier (at protein level) (PubMed:23639800). Detected in erythrocytes (at protein level) (PubMed:11584005, PubMed:23219802). Expressed at relatively high levels in cerebral cortex, particularly the frontal and parietal lobes, and the thalamus and basal ganglia (at protein level) (PubMed:11311901).
In the midbrain expressed at moderate levels, whereas in the other areas of the brainstem, namely medulla and pons, cerebellum and the hippocampus expressed at lower amounts when compared to the other brain regions (at protein level) (PubMed:11311901). Expressed in Langerhans cells and lymphocytes in the pancreas (at protein level) (PubMed:15501974). Expressed in kidney, in polarized renal epithelial cells (PubMed:12527552).
Expressed in adipose tissues (PubMed:35790189). Expressed in placenta (PubMed:8986748). Expressed in small intestine (PubMed:10755314)
Cys-414 near TM10 is a major determinant of nucleobase transport activity
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to SLC29A1, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 9
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT01641575 | Solid Tumor, Non-small-cell Lung Cancer, Lung Cancer | A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin | PHASE1 | TERMINATED |
| NCT01124786 | Metastatic Pancreatic Adenocarcinoma | A Study Comparing CO-1.01 With Gemcitabine as First Line Therapy in Patients With Metastatic Pancreatic Adenocarcinoma (LEAP) | PHASE2 | COMPLETED |
| NCT02486497 | Pancreatic Cancer | Adjuvant Gemcitabine Versus 5-FU/Leucovorin Based on hENT1 Immunostaining | NA | COMPLETED |
| NCT02309658 | Cancer of Cervix | Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer Patients | PHASE2 | COMPLETED |
| NCT01307241 | Acute Lymphoblastic Leukemia., Acute Myeloblastic Leukemia | RFC and MTHFR SNPs & hENT1- dCK Expression as Prognostic Factors in ALL & hENT1- dCK Expression as Prognostic Factors in AML | N/A | UNKNOWN |
| NCT01233375 | Metastatic Pancreatic Adenocarcinoma | Study to Evaluate Efficacy of CO-1.01 as Second Line Therapy for Gemcitabine-Refractory Stage IV Pancreatic Adenocarcinoma | PHASE2 | COMPLETED |
| NCT03610100 | Pancreatic Acinar Carcinoma, Pancreatic Neoplasms | Acelarin First Line Randomised Pancreatic Study | PHASE2, PHASE3 | SUSPENDED |
| NCT01392976 | Advanced Solid Tumor | Safety and Pharmacokinetic Profiles of Two Formulations of CO-1.01 in Patients With Advanced Solid Tumors | PHASE1 | COMPLETED |
| NCT01586611 | Metastatic Pancreas Cancer | A Study to See if hENT1 Testing on Tumour Tissue Can Predict Response to Treatment With Gemcitabine Chemotherapy and if a Different Chemotherapy Called FOLFOX is Better Than Gemcitabine in Metastatic Pancreas Cancer | PHASE3 | UNKNOWN |