Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).
Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303)
Interacts (via the SH2 and SH3 domains) with DOK1 (PubMed:23822091). Interacts with KHDRBS1/SAM68 and VIM (PubMed:29496907)
Highly expressed in most breast cancers (at protein level)
The N-terminal region regulates its kinase activity
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to SRMS, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 2
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT02828709 | Kidney Cancer | Safety and Feasibility of IRE for SRMs | PHASE2 | UNKNOWN |
| NCT03804320 | Kidney Cancer | Protocol Active Surveillance Small Renal Masses (SRMs) | NA | RECRUITING |