Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| medical cannabis | AANAT | Direct | 1 | ||||||||
| nabiximols, temozolomide, nabiximols-matched placebo | AANAT | Direct | 1 | ||||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | EPHB4 | SSL via EPHB4 | 3 | ||||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | TOP1 | SSL via TOP1 | 3 | ||||||||
| lurbinectedin, irinotecan | TOP1 | SSL via TOP1 | 3 | ||||||||
| apatinib, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | TOP1 | SSL via TOP1 | 2 | ||||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | EPHB4 | SSL via EPHB4 | 2 | ||||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | TOP1 | SSL via TOP1 | 2 | ||||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | TOP1 | SSL via TOP1 | 2 | ||||||||
| irinotecan, capecitabine | TOP1 | SSL via TOP1 | 2 | ||||||||
| irinotecan, docetaxel | TOP1 | SSL via TOP1 | 2 | ||||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | TOP1 | SSL via TOP1 | 2 | ||||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| rubitecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| sacituzumab govitecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| topotecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| trastuzumab deruxtecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | TOP1 | SSL via TOP1 | 1 | ||||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| afatinib, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| aldoxorubicin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| amrubicin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| at-101, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avastin, temozolomide, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avastin, temozolomide, radiation therapy (xrt), irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avelumab, irinotecan, paclitaxel, best supportive care (bsc) | TOP1 | SSL via TOP1 | 1 | ||||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | TOP1 | SSL via TOP1 | 1 | ||||||||
| azenosertib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, multigated acquisition scan, trastuzumab deruxtecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | TOP1 | SSL via TOP1 | 1 | ||||||||
| bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| berzosertib, sacituzumab govitecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab [avastin], irinotecan, temozolomide | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, dasatinib, placebo | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, temozolomide, radiation therapy (xrt), topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bi 764532, topotecan, single agent chemotherapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin | TOP1 | SSL via TOP1 | 1 | ||||||||
| biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab | TOP1 | SSL via TOP1 | 1 | ||||||||
| bl-b01d1, irinotecan, paclitaxel, docetaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| bl-b01d1, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bortezomib, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| camrelizumab, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib | TOP1 | SSL via TOP1 | 1 | ||||||||
| capecitabine, oxaliplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| carboplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study | TOP1 | SSL via TOP1 | 1 | ||||||||
| cetuximab, bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| cetuximab, irinotecan, oxaliplatin, uft | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, gleevec™, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, irinotecan, capecitabine | TOP1 | SSL via TOP1 | 1 | ||||||||
| dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| dasatinib, laboratory biomarker analysis, physiologic testing | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| dasatinib, mfolfox6 | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| dasatinib, pharmacological study | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| dasatinib, temozolomide, placebo, radiation therapy | EPHB4 | SSL via EPHB4 | 1 | ||||||||
| digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| doxorubicin, cisplatin, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf | TOP1 | SSL via TOP1 | 1 | ||||||||
| edotecarin, temozolomide, carmustine (bcnu), lomustine (ccnu) | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil (5-fu), capecitabine, durvalumab, oxaliplatin, trastuzumab, trastuzumab deruxtecan, cisplatin, pembrolizumab, volrustomig, rilvegostomig | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, oxaliplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) | TOP1 | SSL via TOP1 | 1 | ||||||||
| gemcitabine, taxotere, xeloda, cisplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| imatinib, irinotecan, carboplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan hydrochloride liposome injection, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, 5-fluorouracil, leucovorin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, bevacizumab, fdopa-pet/mri imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab, radiation | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, cisplatin, simvastatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, ibi343, paclitaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, leucovorin, 5-fluorouracil, docetaxel, cisplatin, leucovorin, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, lurbinectedin, irinotecan, topotecan, lurbinectedin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, ramucirumab, blood for angiome profiling, blood for cfdna | TOP1 | SSL via TOP1 | 1 | ||||||||
| kc1036, irinotecan, docetaxel, s-1 | TOP1 | SSL via TOP1 | 1 | ||||||||
| liposomal irinotecan, 5-fu, lv, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| ljm716, byl719, paclitaxel, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| lurbinectedin, irinotecan, lurbinectedin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| lutetium lu 177 dotatate, capecitabine, temozolomide, quality-of-life assessment, questionnaire administration | SSTR5 | SSL via SSTR5 | 1 | ||||||||
| ly3962673, cetuximab, gemcitabine, nab-paclitaxel, oxaliplatin, leucovorin, irinotecan, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| mri-guided laser heat ablation (mla), doxorubicin, blood draw - dendritic cells, dynamic susceptibility contrast magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan, nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| nab-paclitaxel, gemcitabine, cisplatin, irinotecan, capecitabine, pembrolizumab, olaparib | TOP1 | SSL via TOP1 | 1 |