Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 79 of 79 matching drugs for ADRA1A — including drugs targeting any of its 13 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
chlorpromazine, temozolomide, radiation therapy ADRA1A Direct 1
endoscopic variceal ligation, carvedilol ADRA1A Direct 1
selinexor, temozolomide, generic radiation therapy (rt), selective serotonin receptor (5-ht3) antagonists, olanzapine, salt tablets, anti-diarrheal ADRA1A Direct 1
alfuzosin ADRA1A Direct yes 0
alfuzosin hydrochloride ADRA1A Direct yes 0
carvedilol ADRA1A Direct yes 0
carvedilol phosphate ADRA1A Direct yes 0
dapiprazole ADRA1A Direct yes 0
dapiprazole hydrochloride ADRA1A Direct yes 0
dipivefrin ADRA1A Direct yes 0
dipivefrin hydrochloride ADRA1A Direct yes 0
dopamine ADRA1A Direct yes 0
dopamine hydrochloride ADRA1A Direct yes 0
doxazosin ADRA1A Direct yes 0
doxazosin mesylate ADRA1A Direct yes 0
ephedrine ADRA1A Direct yes 0
ephedrine hydrochloride ADRA1A Direct yes 0
ephedrine sulfate ADRA1A Direct yes 0
epinephrine ADRA1A Direct yes 0
epinephrine bitartrate ADRA1A Direct yes 0
ergoloid ADRA1A Direct yes 0
ergoloid mesylates ADRA1A Direct yes 0
hydroxyamphetamine ADRA1A Direct yes 0
hydroxyamphetamine hydrobromide ADRA1A Direct yes 0
isoxsuprine ADRA1A Direct yes 0
isoxsuprine hydrochloride ADRA1A Direct yes 0
labetalol ADRA1A Direct yes 0
labetalol hydrochloride ADRA1A Direct yes 0
levonordefrin ADRA1A Direct yes 0
mephentermine ADRA1A Direct yes 0
mephentermine sulfate ADRA1A Direct yes 0
metaraminol ADRA1A Direct yes 0
metaraminol bitartrate ADRA1A Direct yes 0
methoxamine ADRA1A Direct yes 0
methoxamine hydrochloride ADRA1A Direct yes 0
midodrine ADRA1A Direct yes 0
midodrine hydrochloride ADRA1A Direct yes 0
moxisylyte ADRA1A Direct yes 0
naphazoline ADRA1A Direct yes 0
naphazoline hydrochloride ADRA1A Direct yes 0
norepinephrine ADRA1A Direct yes 0
norepinephrine bitartrate ADRA1A Direct yes 0
olanzapine ADRA1A Direct yes 0
olanzapine pamoate ADRA1A Direct yes 0
oxymetazoline ADRA1A Direct yes 0
oxymetazoline hydrochloride ADRA1A Direct yes 0
phenoxybenzamine ADRA1A Direct yes 0
phenoxybenzamine hydrochloride ADRA1A Direct yes 0
phentolamine ADRA1A Direct yes 0
phentolamine mesylate ADRA1A Direct yes 0
phenylephrine ADRA1A Direct yes 0
phenylephrine bitartrate ADRA1A Direct yes 0
phenylephrine hydrochloride ADRA1A Direct yes 0
phenylpropanolamine ADRA1A Direct yes 0
phenylpropanolamine hydrochloride ADRA1A Direct yes 0
prazosin ADRA1A Direct yes 0
prazosin hydrochloride ADRA1A Direct yes 0
pseudoephedrine ADRA1A Direct yes 0
pseudoephedrine hydrochloride ADRA1A Direct yes 0
pseudoephedrine sulfate ADRA1A Direct yes 0
quetiapine ADRA1A Direct yes 0
quetiapine fumarate ADRA1A Direct yes 0
sertindole ADRA1A Direct yes 0
silodosin ADRA1A Direct yes 0
tamsulosin ADRA1A Direct yes 0
tamsulosin hydrochloride ADRA1A Direct yes 0
terazosin ADRA1A Direct yes 0
terazosin hydrochloride ADRA1A Direct yes 0
tetrahydrozoline ADRA1A Direct yes 0
tetrahydrozoline hydrochloride ADRA1A Direct yes 0
tolazoline ADRA1A Direct yes 0
tolazoline hydrochloride ADRA1A Direct yes 0
trimipramine ADRA1A Direct yes 0
trimipramine maleate ADRA1A Direct yes 0
ziprasidone ADRA1A Direct yes 0
ziprasidone hydrochloride ADRA1A Direct yes 0
ziprasidone mesylate ADRA1A Direct yes 0
gabapentin, sulfasalazine, memantine, temozolomide, radiotherapy NFKB2 SSL via NFKB2 1
sulfasalazine NFKB2 SSL via NFKB2 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.