Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:7746284). ADRA1D binds the catecholamine ligands norepinephrine and epinephrine (PubMed:7815325, PubMed:8024574, PubMed:8183249)
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA
No mutation information available.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to ADRA1A, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 1
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT03132272 | Alzheimer Dementia | Immunoadsorption for Treatment of Alzheimer's Disease | NA | TERMINATED |