Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 94 of 94 matching drugs for ALK — including drugs targeting any of its 29 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib ALK Direct 3
crizotinib ALK Direct yes 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel ALK Direct 2
alectinib, stereotactic radiosurgery ALK Direct 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib ALK Direct 2
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib ALK Direct 1
biopsy, biospecimen collection, crizotinib, radiologic examination ALK Direct 1
ceritinib, cisplatin, gemcitabine hydrochloride, laboratory biomarker analysis, paclitaxel albumin-stabilized nanoparticle formulation, pharmacological study ALK Direct 1
lorlatinib, lorlatinib with chemotherapy1, lorlatinib with chemotherapy 2, lorlatinib post radiation ALK Direct 1
alectinib ALK Direct yes 0
alectinib hydrochloride ALK Direct yes 0
brigatinib ALK Direct yes 0
ceritinib ALK Direct yes 0
entrectinib ALK Direct yes 0
lorlatinib ALK Direct yes 0
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib BTK SSL via BTK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib SMO SSL via SMO 3
alvocidib, paclitaxel CDK9 SSL via CDK9 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment BTK SSL via BTK 2
ibrutinib BTK SSL via BTK yes 2
motexafin gadolinium, radiation therapy RRM2 SSL via RRM2 2
pembrolizumab, sonidegib SMO SSL via SMO 2
3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide RRM2 SSL via RRM2 1
afatinib, dasatinib, palbociclib, everolimus, olaparib BTK SSL via BTK 1
alvocidib, docetaxel CDK9 SSL via CDK9 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis CDK9 SSL via CDK9 1
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib SMO SSL via SMO 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine DBH SSL via DBH 1
atezolizumab, tivozanib PTK6 SSL via PTK6 1
bevacizumab, dasatinib, placebo BTK SSL via BTK 1
biopsy, biospecimen collection, echocardiography, radionuclide imaging, vismodegib SMO SSL via SMO 1
chemotherapy, cladribine, radiation therapy RRM2 SSL via RRM2 1
chemotherapy, disulfiram, gemcitabine hydrochloride, laboratory biomarker analysis DBH SSL via DBH 1
conventional surgery, 3-dimensional conformal radiation therapy, stereotactic radiosurgery, motexafin gadolinium, magnetic resonance imaging, spectroscopy RRM2 SSL via RRM2 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride BTK SSL via BTK 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method BTK SSL via BTK 1
dasatinib, laboratory biomarker analysis, physiologic testing BTK SSL via BTK 1
dasatinib, mfolfox6 BTK SSL via BTK 1
dasatinib, pharmacological study BTK SSL via BTK 1
dasatinib, temozolomide, placebo, radiation therapy BTK SSL via BTK 1
diagnostic laboratory biomarker analysis, erlotinib hydrochloride, gemcitabine hydrochloride, vismodegib SMO SSL via SMO 1
disulfiram, copper gluconate, surgery, radiation, temozolomide DBH SSL via DBH 1
disulfiram, copper, alkylating agents DBH SSL via DBH 1
gemcitabine hydrochloride, hydrocortisone/placebo, vismodegib SMO SSL via SMO 1
gemcitabine, ribociclib, sonidegib, trametinib, filgrastim SMO SSL via SMO 1
ibrutinib, durvalumab BTK SSL via BTK 1
ibrutinib, fludarabine BTK SSL via BTK 1
ibrutinib, gemcitabine, nab-paclitaxel BTK SSL via BTK 1
ibrutinib, indoximod, cyclophosphamide, etoposide BTK SSL via BTK 1
ibrutinib, paclitaxel, gemcitabine BTK SSL via BTK 1
ibrutinib, radiation, temozolomide (tmz) BTK SSL via BTK 1
imexon, gemcitabine RRM2 SSL via RRM2 1
lutetium lu 177 dotatate, capecitabine, temozolomide, quality-of-life assessment, questionnaire administration SSTR5 SSL via SSTR5 1
motexafin gadolinium RRM2 SSL via RRM2 1
motexafin gadolinium, magnetic resonance imaging, surgical procedure RRM2 SSL via RRM2 1
oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, ascorbic acid DBH SSL via DBH 1
ryz101, everolimus, sunitinib, octreotide, lanreotide SSTR5 SSL via SSTR5 1
sirolimus, vandetanib PTK6 SSL via PTK6 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide SSTR5 SSL via SSTR5 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin DBH SSL via DBH 1
temozolomide, disulfiram, copper gluconate DBH SSL via DBH 1
temozolomide, radiation therapy, ascorbic acid DBH SSL via DBH 1
tivozanib PTK6 SSL via PTK6 1
trilaciclib CDK9 SSL via CDK9 1
vandetanib PTK6 SSL via PTK6 yes 1
vandetanib, 5 fluorouracil (fu), carboplatin, paclitaxel, external beam radiation therapy (rt) PTK6 SSL via PTK6 1
vandetanib, adjuvant therapy PTK6 SSL via PTK6 1
vismodegib, sirolimus, positron emission tomography, computed tomography, pharmacological study, laboratory biomarker analysis, fludeoxyglucose f 18 SMO SSL via SMO 1
vismodegib, therapeutic conventional surgery, laboratory biomarker analysis, pharmacological study SMO SSL via SMO 1
acalabrutinib BTK SSL via BTK yes 0
clofarabine RRM2 SSL via RRM2 yes 0
gallium citrate RRM2 SSL via RRM2 yes 0
gallium citrate ga 67 RRM2 SSL via RRM2 yes 0
gallium nitrate RRM2 SSL via RRM2 yes 0
gallium oxodotreotide RRM2 SSL via RRM2 yes 0
gallium oxodotreotide ga-68 RRM2 SSL via RRM2 yes 0
gemcitabine RRM2 SSL via RRM2 yes 0
gemcitabine hydrochloride RRM2 SSL via RRM2 yes 0
glasdegib SMO SSL via SMO yes 0
glasdegib maleate SMO SSL via SMO yes 0
hydroxyurea RRM2 SSL via RRM2 yes 0
lanreotide SSTR5 SSL via SSTR5 yes 0
lanreotide acetate SSTR5 SSL via SSTR5 yes 0
lemborexant HCRTR1 SSL via HCRTR1 yes 0
octreotide SSTR5 SSL via SSTR5 yes 0
octreotide acetate SSTR5 SSL via SSTR5 yes 0
pasireotide SSTR5 SSL via SSTR5 yes 0
pasireotide diaspartate SSTR5 SSL via SSTR5 yes 0
pasireotide pamoate SSTR5 SSL via SSTR5 yes 0
sonidegib SMO SSL via SMO yes 0
sonidegib phosphate SMO SSL via SMO yes 0
suvorexant HCRTR1 SSL via HCRTR1 yes 0
vismodegib SMO SSL via SMO yes 0
zanubrutinib BTK SSL via BTK yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.