Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 99 of 99 matching drugs for PIK3CD — including drugs targeting any of its 31 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CD Direct 3
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CD Direct 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CD Direct 1
copanlisib PIK3CD Direct yes 0
copanlisib hydrochloride PIK3CD Direct yes 0
duvelisib PIK3CD Direct yes 0
idelalisib PIK3CD Direct yes 0
umbralisib PIK3CD Direct yes 0
umbralisib tosylate PIK3CD Direct yes 0
sunitinib CSF1R SSL via CSF1R yes 5
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib CSF1R SSL via CSF1R 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib CSK SSL via CSK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CA SSL via PIK3CA 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CG SSL via PIK3CG 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel IGF1R SSL via IGF1R 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment CSK SSL via CSK 2
cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study IGF1R SSL via IGF1R 2
cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study IGF1R SSL via IGF1R 2
afatinib, dasatinib, palbociclib, everolimus, olaparib CSK SSL via CSK 1
alpelisib, everolimus, exemestane PIK3CA SSL via PIK3CA 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine DBH SSL via DBH 1
atorvastatin, temozolomide, radiotherapy HMGCR SSL via HMGCR 1
bevacizumab, dasatinib, placebo CSK SSL via CSK 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CA SSL via PIK3CA 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CG SSL via PIK3CG 1
biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging, sunitinib CSF1R SSL via CSF1R 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging CSF1R SSL via CSF1R 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CA SSL via PIK3CA 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CG SSL via PIK3CG 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography CSF1R SSL via CSF1R 1
chemotherapy, disulfiram, gemcitabine hydrochloride, laboratory biomarker analysis DBH SSL via DBH 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride CSK SSL via CSK 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method CSK SSL via CSK 1
dasatinib, laboratory biomarker analysis, physiologic testing CSK SSL via CSK 1
dasatinib, mfolfox6 CSK SSL via CSK 1
dasatinib, pharmacological study CSK SSL via CSK 1
dasatinib, temozolomide, placebo, radiation therapy CSK SSL via CSK 1
disulfiram, copper gluconate, surgery, radiation, temozolomide DBH SSL via DBH 1
disulfiram, copper, alkylating agents DBH SSL via DBH 1
erdafitinib CSF1R SSL via CSF1R 1
gemcitabine, oxaliplatin, imatinib CSF1R SSL via CSF1R 1
gemcitabine, sunitinib CSF1R SSL via CSF1R 1
imatinib, irinotecan, carboplatin CSF1R SSL via CSF1R 1
insulin degludec, insulin glargine IGF1R SSL via IGF1R 1
irinotecan, cisplatin, simvastatin HMGCR SSL via HMGCR 1
laboratory biomarker analysis, linsitinib, pharmacological study, topotecan hydrochloride IGF1R SSL via IGF1R 1
lutetium lu 177 dotatate, capecitabine, temozolomide, quality-of-life assessment, questionnaire administration SSTR5 SSL via SSTR5 1
medical cannabis HMGCR SSL via HMGCR 1
nabiximols, temozolomide, nabiximols-matched placebo HMGCR SSL via HMGCR 1
oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, ascorbic acid DBH SSL via DBH 1
pexidartinib, durvalumab CSF1R SSL via CSF1R 1
rosuvastatin HMGCR SSL via HMGCR yes 1
ryz101, everolimus, sunitinib, octreotide, lanreotide CSF1R SSL via CSF1R 1
ryz101, everolimus, sunitinib, octreotide, lanreotide SSTR5 SSL via SSTR5 1
semaglutide, insulin aspart, insulin glargine u100 IGF1R SSL via IGF1R 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide SSTR5 SSL via SSTR5 1
sunitinib, placebo CSF1R SSL via CSF1R 1
sunitinib, radiation CSF1R SSL via CSF1R 1
sunitinib, sunitinib CSF1R SSL via CSF1R 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin DBH SSL via DBH 1
temozolomide, disulfiram, copper gluconate DBH SSL via DBH 1
temozolomide, radiation therapy, ascorbic acid DBH SSL via DBH 1
alpelisib PIK3CA SSL via PIK3CA yes 0
atorvastatin HMGCR SSL via HMGCR yes 0
atorvastatin calcium HMGCR SSL via HMGCR yes 0
brigatinib IGF1R SSL via IGF1R yes 0
cerivastatin HMGCR SSL via HMGCR yes 0
cerivastatin sodium HMGCR SSL via HMGCR yes 0
copanlisib PIK3CA SSL via PIK3CA yes 0
copanlisib hydrochloride PIK3CA SSL via PIK3CA yes 0
duvelisib PIK3CG SSL via PIK3CG yes 0
fluvastatin HMGCR SSL via HMGCR yes 0
fluvastatin sodium HMGCR SSL via HMGCR yes 0
lanreotide SSTR5 SSL via SSTR5 yes 0
lanreotide acetate SSTR5 SSL via SSTR5 yes 0
lemborexant HCRTR1 SSL via HCRTR1 yes 0
lovastatin HMGCR SSL via HMGCR yes 0
mecasermin IGF1R SSL via IGF1R yes 0
mecasermin rinfabate IGF1R SSL via IGF1R yes 0
octreotide SSTR5 SSL via SSTR5 yes 0
octreotide acetate SSTR5 SSL via SSTR5 yes 0
pasireotide SSTR5 SSL via SSTR5 yes 0
pasireotide diaspartate SSTR5 SSL via SSTR5 yes 0
pasireotide pamoate SSTR5 SSL via SSTR5 yes 0
pazopanib CSF1R SSL via CSF1R yes 0
pazopanib hydrochloride CSF1R SSL via CSF1R yes 0
pexidartinib CSF1R SSL via CSF1R yes 0
pexidartinib hydrochloride CSF1R SSL via CSF1R yes 0
pitavastatin HMGCR SSL via HMGCR yes 0
pitavastatin calcium HMGCR SSL via HMGCR yes 0
pitavastatin magnesium HMGCR SSL via HMGCR yes 0
pitavastatin sodium HMGCR SSL via HMGCR yes 0
pravastatin HMGCR SSL via HMGCR yes 0
pravastatin sodium HMGCR SSL via HMGCR yes 0
rosuvastatin calcium HMGCR SSL via HMGCR yes 0
simvastatin HMGCR SSL via HMGCR yes 0
somatropin IGF1R SSL via IGF1R yes 0
sunitinib malate CSF1R SSL via CSF1R yes 0
suvorexant HCRTR1 SSL via HCRTR1 yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.