Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 52 of 52 matching drugs for PPARD — including drugs targeting any of its 16 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone PPARD Direct 3
adjuvant therapy, temozolomide, valproic acid, radiation therapy PPARD Direct 1
adriamycin, cyclophosphamide, vindesine, valproic acid PPARD Direct 1
sorafenib tosylate, valproic acid, sildenafil citrate PPARD Direct 1
valproic acid PPARD Direct 1
valproic acid, bevacizumab, radiation therapy PPARD Direct 1
valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine PPARD Direct 1
bezafibrate PPARD Direct yes 0
adagrasib KRAS SSL via KRAS yes 2
sotorasib KRAS SSL via KRAS yes 2
alendronate, etidronate, ibandronate, risedronate, raloxifene ESR1 SSL via ESR1 2
eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab ESR1 SSL via ESR1 2
gefitinib, fulvestrant, erlotinib ESR1 SSL via ESR1 2
sy-5609, fulvestrant, gemcitabine, nab-paclitaxel ESR1 SSL via ESR1 2
blu-222, carboplatin, ribociclib, fulvestrant ESR1 SSL via ESR1 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin TP53 SSL via TP53 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride ESR1 SSL via ESR1 1
levonorgestrel, metformin ESR1 SSL via ESR1 1
omeprazole, melatonin ESR1 SSL via ESR1 1
pf-07220060, letrozole, fulvestrant, midazolam, enzalutamide ESR1 SSL via ESR1 1
tamoxifen, etoposide ESR1 SSL via ESR1 1
allylestrenol ESR1 SSL via ESR1 yes 0
bazedoxifene ESR1 SSL via ESR1 yes 0
bazedoxifene acetate ESR1 SSL via ESR1 yes 0
clomiphene ESR1 SSL via ESR1 yes 0
clomiphene citrate ESR1 SSL via ESR1 yes 0
cyclofenil ESR1 SSL via ESR1 yes 0
danazol ESR1 SSL via ESR1 yes 0
dienestrol ESR1 SSL via ESR1 yes 0
diethylstilbestrol ESR1 SSL via ESR1 yes 0
diethylstilbestrol diphosphate ESR1 SSL via ESR1 yes 0
estetrol ESR1 SSL via ESR1 yes 0
estradiol ESR1 SSL via ESR1 yes 0
estradiol acetate ESR1 SSL via ESR1 yes 0
estradiol benzoate ESR1 SSL via ESR1 yes 0
estradiol cypionate ESR1 SSL via ESR1 yes 0
estradiol valerate ESR1 SSL via ESR1 yes 0
estriol ESR1 SSL via ESR1 yes 0
estrone ESR1 SSL via ESR1 yes 0
estrone sulfuric acid ESR1 SSL via ESR1 yes 0
estropipate ESR1 SSL via ESR1 yes 0
ethinyl estradiol ESR1 SSL via ESR1 yes 0
fulvestrant ESR1 SSL via ESR1 yes 0
lasofoxifene ESR1 SSL via ESR1 yes 0
mestranol ESR1 SSL via ESR1 yes 0
ospemifene ESR1 SSL via ESR1 yes 0
polyestradiol phosphate ESR1 SSL via ESR1 yes 0
quinestrol ESR1 SSL via ESR1 yes 0
tamoxifen ESR1 SSL via ESR1 yes 0
tamoxifen citrate ESR1 SSL via ESR1 yes 0
toremifene ESR1 SSL via ESR1 yes 0
toremifene citrate ESR1 SSL via ESR1 yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.