Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| pazopanib | SH2B3 | Direct | 2 | ||||||||
| pazopanib, 5-fu, oxaliplatin, leukovorin (flo) | SH2B3 | Direct | 1 | ||||||||
| pazopanib, lapatinib | SH2B3 | Direct | 1 | ||||||||
| pazopanib, placebo | SH2B3 | Direct | 1 | ||||||||
| pegilodecakin, paclitaxel or docetaxel and carboplatin or cisplatin, folfox (oxaliplatin/leucovorin/5-fluorouracil), gemcitabine/nab-paclitaxel, capecitabine, pazopanib, pembrolizumab, paclitaxel, nivolumab, gemcitabine/carboplatin | SH2B3 | Direct | 1 | ||||||||
| topotecan, pazopanib | SH2B3 | Direct | 1 | ||||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | RET | SSL via RET | 4 | ||||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | RET | SSL via RET | 4 | ||||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | MST1R | SSL via MST1R | 3 | ||||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | RET | SSL via RET | 3 | ||||||||
| crizotinib | MST1R | SSL via MST1R | 3 | ||||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | TOP1MT | SSL via TOP1MT | 3 | ||||||||
| lurbinectedin, irinotecan | TOP1MT | SSL via TOP1MT | 3 | ||||||||
| pembrolizumab, belzutifan, lenvatinib | RET | SSL via RET | 3 | ||||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | RET | SSL via RET | 2 | ||||||||
| alvocidib, paclitaxel | CDK9 | SSL via CDK9 | 2 | ||||||||
| apatinib, irinotecan | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| cabozantinib | RET | SSL via RET | 2 | ||||||||
| cabozantinib, atezolizumab, cabozantinib, cabozantinib | RET | SSL via RET | 2 | ||||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | RET | SSL via RET | 2 | ||||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | HDAC3 | SSL via HDAC3 | 2 | ||||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | RET | SSL via RET | 2 | ||||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| irinotecan, capecitabine | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| irinotecan, docetaxel | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| lenvatinib, pembrolizumab | RET | SSL via RET | 2 | ||||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | RET | SSL via RET | 2 | ||||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | RET | SSL via RET | 2 | ||||||||
| pembrolizumab, guadecitabine, mocetinostat | HDAC3 | SSL via HDAC3 | 2 | ||||||||
| pembrolizumab, lenvatinib | RET | SSL via RET | 2 | ||||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | RET | SSL via RET | 2 | ||||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | RET | SSL via RET | 2 | ||||||||
| quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery | RET | SSL via RET | 2 | ||||||||
| regorafenib | RET | SSL via RET | yes | 2 | |||||||
| regorafenib, laboratory biomarker analysis | RET | SSL via RET | 2 | ||||||||
| sorafenib, administered orally, ct/mri | RET | SSL via RET | 2 | ||||||||
| topotecan | TOP1MT | SSL via TOP1MT | 2 | ||||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | HDAC3 | SSL via HDAC3 | 1 | ||||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | HDAC3 | SSL via HDAC3 | 1 | ||||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| acetazolamide, temozolomide | CA14 | SSL via CA14 | 1 | ||||||||
| afatinib, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| aldoxorubicin, topotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| alvocidib, docetaxel | CDK9 | SSL via CDK9 | 1 | ||||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | CDK9 | SSL via CDK9 | 1 | ||||||||
| aminolevulinic acid | ALAD | SSL via ALAD | 1 | ||||||||
| aminolevulinic acid, surgical resection | ALAD | SSL via ALAD | 1 | ||||||||
| amrubicin, topotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| at-101, topotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| atezolizumab, cabozantinib | RET | SSL via RET | 1 | ||||||||
| atorvastatin, temozolomide, radiotherapy | NR1I3 | SSL via NR1I3 | 1 | ||||||||
| avastin, temozolomide, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| avastin, temozolomide, radiation therapy (xrt), irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| avelumab, irinotecan, paclitaxel, best supportive care (bsc) | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | HDAC3 | SSL via HDAC3 | 1 | ||||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bevacizumab [avastin], irinotecan, temozolomide | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bevacizumab, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bevacizumab, temozolomide, radiation therapy (xrt), topotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bevacizumab, temozolomide, vorinostat | HDAC3 | SSL via HDAC3 | 1 | ||||||||
| bi 764532, topotecan, single agent chemotherapy | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging | RET | SSL via RET | 1 | ||||||||
| biopsy, biospecimen collection, crizotinib, radiologic examination | MST1R | SSL via MST1R | 1 | ||||||||
| biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography | RET | SSL via RET | 1 | ||||||||
| bl-b01d1, irinotecan, paclitaxel, docetaxel | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bl-b01d1, topotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| bortezomib, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cabozantinib, durvalumab, tremelimumab | RET | SSL via RET | 1 | ||||||||
| cabozantinib, nivolumab | RET | SSL via RET | 1 | ||||||||
| cabozantinib, pembrolizumab | RET | SSL via RET | 1 | ||||||||
| camrelizumab, docetaxel, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| capecitabine, oxaliplatin, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| capecitabine, vorinostat, radiotherapy, surgery to remove tumor | HDAC3 | SSL via HDAC3 | 1 | ||||||||
| carboplatin, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cetuximab, bevacizumab, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cetuximab, irinotecan, oxaliplatin, uft | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cisplatin, gleevec™, irinotecan | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cisplatin, irinotecan, capecitabine | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| cisplatin, pemetrexed disodium, sorafenib | RET | SSL via RET | 1 | ||||||||
| digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf | TOP1MT | SSL via TOP1MT | 1 | ||||||||
| eras-007, encorafenib, cetuximab, palbociclib | LIMK2 | SSL via LIMK2 | 1 |