Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 71 of 71 matching drugs for SSTR5 — including drugs targeting any of its 31 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
lutetium lu 177 dotatate, capecitabine, temozolomide, quality-of-life assessment, questionnaire administration SSTR5 Direct 1
ryz101, everolimus, sunitinib, octreotide, lanreotide SSTR5 Direct 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide SSTR5 Direct 1
lanreotide SSTR5 Direct yes 0
lanreotide acetate SSTR5 Direct yes 0
octreotide SSTR5 Direct yes 0
octreotide acetate SSTR5 Direct yes 0
pasireotide SSTR5 Direct yes 0
pasireotide diaspartate SSTR5 Direct yes 0
pasireotide pamoate SSTR5 Direct yes 0
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib ALK SSL via ALK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CD SSL via PIK3CD 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CG SSL via PIK3CG 3
crizotinib ALK SSL via ALK yes 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel ALK SSL via ALK 2
alectinib, stereotactic radiosurgery ALK SSL via ALK 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib ALK SSL via ALK 2
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib ALK SSL via ALK 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine DBH SSL via DBH 1
atorvastatin, temozolomide, radiotherapy HMGCR SSL via HMGCR 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CD SSL via PIK3CD 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CG SSL via PIK3CG 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CD SSL via PIK3CD 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CG SSL via PIK3CG 1
biopsy, biospecimen collection, crizotinib, radiologic examination ALK SSL via ALK 1
ceritinib, cisplatin, gemcitabine hydrochloride, laboratory biomarker analysis, paclitaxel albumin-stabilized nanoparticle formulation, pharmacological study ALK SSL via ALK 1
chemotherapy, disulfiram, gemcitabine hydrochloride, laboratory biomarker analysis DBH SSL via DBH 1
disulfiram, copper gluconate, surgery, radiation, temozolomide DBH SSL via DBH 1
disulfiram, copper, alkylating agents DBH SSL via DBH 1
irinotecan, cisplatin, simvastatin HMGCR SSL via HMGCR 1
lorlatinib, lorlatinib with chemotherapy1, lorlatinib with chemotherapy 2, lorlatinib post radiation ALK SSL via ALK 1
medical cannabis AANAT SSL via AANAT 1
medical cannabis HMGCR SSL via HMGCR 1
nabiximols, temozolomide, nabiximols-matched placebo AANAT SSL via AANAT 1
nabiximols, temozolomide, nabiximols-matched placebo HMGCR SSL via HMGCR 1
oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, ascorbic acid DBH SSL via DBH 1
rosuvastatin HMGCR SSL via HMGCR yes 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin DBH SSL via DBH 1
temozolomide, disulfiram, copper gluconate DBH SSL via DBH 1
temozolomide, radiation therapy, ascorbic acid DBH SSL via DBH 1
alectinib ALK SSL via ALK yes 0
alectinib hydrochloride ALK SSL via ALK yes 0
alpidem TSPO SSL via TSPO yes 0
atorvastatin HMGCR SSL via HMGCR yes 0
atorvastatin calcium HMGCR SSL via HMGCR yes 0
brigatinib ALK SSL via ALK yes 0
ceritinib ALK SSL via ALK yes 0
cerivastatin HMGCR SSL via HMGCR yes 0
cerivastatin sodium HMGCR SSL via HMGCR yes 0
copanlisib PIK3CD SSL via PIK3CD yes 0
copanlisib hydrochloride PIK3CD SSL via PIK3CD yes 0
duvelisib PIK3CD SSL via PIK3CD yes 0
duvelisib PIK3CG SSL via PIK3CG yes 0
entrectinib ALK SSL via ALK yes 0
fluvastatin HMGCR SSL via HMGCR yes 0
fluvastatin sodium HMGCR SSL via HMGCR yes 0
idelalisib PIK3CD SSL via PIK3CD yes 0
lemborexant HCRTR1 SSL via HCRTR1 yes 0
lorlatinib ALK SSL via ALK yes 0
lovastatin HMGCR SSL via HMGCR yes 0
pitavastatin HMGCR SSL via HMGCR yes 0
pitavastatin calcium HMGCR SSL via HMGCR yes 0
pitavastatin magnesium HMGCR SSL via HMGCR yes 0
pitavastatin sodium HMGCR SSL via HMGCR yes 0
pravastatin HMGCR SSL via HMGCR yes 0
pravastatin sodium HMGCR SSL via HMGCR yes 0
rosuvastatin calcium HMGCR SSL via HMGCR yes 0
simvastatin HMGCR SSL via HMGCR yes 0
suvorexant HCRTR1 SSL via HCRTR1 yes 0
umbralisib PIK3CD SSL via PIK3CD yes 0
umbralisib tosylate PIK3CD SSL via PIK3CD yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.