Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| patupilone | TUBA1B | Direct | 1 | ||||||||
| belantamab mafodotin | TUBA1B | Direct | yes | 0 | |||||||
| docetaxel | TUBA1B | Direct | yes | 0 | |||||||
| eribulin | TUBA1B | Direct | yes | 0 | |||||||
| eribulin mesylate | TUBA1B | Direct | yes | 0 | |||||||
| vinblastine | TUBA1B | Direct | yes | 0 | |||||||
| vinblastine sulfate | TUBA1B | Direct | yes | 0 | |||||||
| vincristine | TUBA1B | Direct | yes | 0 | |||||||
| vincristine sulfate | TUBA1B | Direct | yes | 0 | |||||||
| vinorelbine | TUBA1B | Direct | yes | 0 | |||||||
| vinorelbine tartrate | TUBA1B | Direct | yes | 0 | |||||||
| adagrasib | KRAS | SSL via KRAS | yes | 2 | |||||||
| afatinib | EGFR | SSL via EGFR | yes | 2 | |||||||
| dacomitinib | EGFR | SSL via EGFR | yes | 2 | |||||||
| erlotinib | EGFR | SSL via EGFR | yes | 2 | |||||||
| gefitinib | EGFR | SSL via EGFR | yes | 2 | |||||||
| sotorasib | KRAS | SSL via KRAS | yes | 2 | |||||||
| lazertinib and amivantamab | EGFR | SSL via EGFR | 1 | ||||||||
| osimertinib | EGFR | SSL via EGFR | yes | 1 | |||||||
| vinorelbine, cisplatin, vinorelbine, cisplatin, radiotherapy | TUBB | SSL via TUBB | 2 | ||||||||
| ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin | HSPA5 | SSL via HSPA5 | 1 | ||||||||
| concomitant temozolomide (tmz), radiotherapy, procarbazine, adjuvant temozolomide (tmz), ccnu, vincristine | TUBB | SSL via TUBB | 1 | ||||||||
| dabrafenib, trametinib, carboplatin, vincristine | TUBB | SSL via TUBB | 1 | ||||||||
| depatuxizumab mafodotin, temozolomide, lomustine | TUBB | SSL via TUBB | 1 | ||||||||
| disulfiram, copper, alkylating agents | HSPA5 | SSL via HSPA5 | 1 | ||||||||
| disulfiram, copper, alkylating agents | PRDX1 | SSL via PRDX1 | 1 | ||||||||
| disulfiram, copper, alkylating agents | TUBB | SSL via TUBB | 1 | ||||||||
| docetaxel, cisplatin, radiation, surgery, vinorelbine, cisplatin | TUBB | SSL via TUBB | 1 | ||||||||
| gemcitabine, vinorelbine, cisplatin, etoposide, carboplatin | TUBB | SSL via TUBB | 1 | ||||||||
| mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan | TUBB | SSL via TUBB | 1 | ||||||||
| patupilone | TUBB | SSL via TUBB | 1 | ||||||||
| recombinant interferon alfa-2b, cisplatin, sodium stibogluconate, dacarbazine, vinblastine | TUBB | SSL via TUBB | 1 | ||||||||
| temozolomide, depatuxizumab mafodotin, radiation, placebo for abt-414 | TUBB | SSL via TUBB | 1 | ||||||||
| trametinib, vinblastine | TUBB | SSL via TUBB | 1 | ||||||||
| vinorelbine | TUBB | SSL via TUBB | yes | 1 | |||||||
| vinorelbine, xr9576 | TUBB | SSL via TUBB | 1 | ||||||||
| afatinib dimaleate | EGFR | SSL via EGFR | yes | 0 | |||||||
| belantamab mafodotin | TUBB | SSL via TUBB | yes | 0 | |||||||
| cabazitaxel | TUBB | SSL via TUBB | yes | 0 | |||||||
| cetuximab | EGFR | SSL via EGFR | yes | 0 | |||||||
| docetaxel | TUBB | SSL via TUBB | yes | 0 | |||||||
| eribulin | TUBB | SSL via TUBB | yes | 0 | |||||||
| eribulin mesylate | TUBB | SSL via TUBB | yes | 0 | |||||||
| erlotinib hydrochloride | EGFR | SSL via EGFR | yes | 0 | |||||||
| lapatinib | EGFR | SSL via EGFR | yes | 0 | |||||||
| lapatinib ditosylate | EGFR | SSL via EGFR | yes | 0 | |||||||
| necitumumab | EGFR | SSL via EGFR | yes | 0 | |||||||
| neratinib | EGFR | SSL via EGFR | yes | 0 | |||||||
| neratinib maleate | EGFR | SSL via EGFR | yes | 0 | |||||||
| osimertinib mesylate | EGFR | SSL via EGFR | yes | 0 | |||||||
| panitumumab | EGFR | SSL via EGFR | yes | 0 | |||||||
| regorafenib | EGFR | SSL via EGFR | yes | 0 | |||||||
| vandetanib | EGFR | SSL via EGFR | yes | 0 | |||||||
| vinblastine | TUBB | SSL via TUBB | yes | 0 | |||||||
| vinblastine sulfate | TUBB | SSL via TUBB | yes | 0 | |||||||
| vincristine | TUBB | SSL via TUBB | yes | 0 | |||||||
| vincristine sulfate | TUBB | SSL via TUBB | yes | 0 | |||||||
| vindesine | TUBB | SSL via TUBB | yes | 0 | |||||||
| vindesine sulfate | TUBB | SSL via TUBB | yes | 0 | |||||||
| vinflunine | TUBB | SSL via TUBB | yes | 0 | |||||||
| vinorelbine tartrate | TUBB | SSL via TUBB | yes | 0 |