TUBA1B

Tubulin alpha-1B chain • UniProt accession P68363

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661)

Source: UniProt

Heterodimer of alpha- and beta-tubulin (PubMed:17563362, PubMed:34996871, PubMed:35482892, PubMed:38305685, PubMed:38609661). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM (PubMed:34996871, PubMed:35482892). Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity (PubMed:34996871, PubMed:35482892, PubMed:38305685, PubMed:38609661).

Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells (PubMed:34996871, PubMed:35482892, PubMed:38305685, PubMed:38609661). Interacts with gamma-tubulin; the interaction allows microtubules to nucleate from the gamma-tubulin ring complex (gTuRC) (PubMed:38305685, PubMed:38609661). Nascent microtubule interacts (via alpha-tubulin MREC motif) with TTC5/STRAP; this interaction may result in tubulin mRNA-targeted degradation (PubMed:31727855).

Component of sperm flagellar doublet microtubules (By similarity)

Source: UniProt
Cytoplasm, cytoskeleton
Source: UniProt

The MREC motif mediates interaction with TTC5/STRAP and may be critical for tubulin autoregulation

Source: UniProt
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
  • Gap junction assembly
  • MHC class II antigen presentation
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
  • Recruitment of NuMA to mitotic centrosomes
  • Formation of tubulin folding intermediates by CCT/TriC
  • Post-chaperonin tubulin folding pathway
  • Recycling pathway of L1
  • Hedgehog 'off' state
  • Cilium Assembly
  • Intraflagellar transport
  • RHO GTPases activate IQGAPs
  • RHO GTPases Activate Formins
  • COPI-mediated anterograde transport
  • COPI-dependent Golgi-to-ER retrograde traffic
  • COPI-independent Golgi-to-ER retrograde traffic
  • Mitotic Prometaphase
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • Carboxyterminal post-translational modifications of tubulin
  • RHOH GTPase cycle
  • HCMV Early Events
  • Assembly and cell surface presentation of NMDA receptors
  • Activation of AMPK downstream of NMDARs
  • Aggrephagy
  • EML4 and NUDC in mitotic spindle formation
  • Sealing of the nuclear envelope (NE) by ESCRT-III
  • Kinesins
  • PKR-mediated signaling
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to TUBA1B, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.