IGFALS

Insulin-like growth factor-binding protein complex acid labile subunit • UniProt accession P35858

Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion

Source: UniProt

Forms a ternary complex with IGF1 and IGFBP3 (PubMed:35907924)

Source: UniProt
Secreted, extracellular space
Source: UniProt

Plasma

Source: UniProt
  • Acid-labile subunit deficiency (ACLSD)

    A disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings.

Source: UniProt
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Source: Reactome via UniProt

Mutations

No mutation information available.

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to IGFALS, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.