Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| nicotinamide, placebo | BST1 | Direct | 1 | ||||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | TOP1 | SSL via TOP1 | 3 | ||||||||
| lurbinectedin, irinotecan | TOP1 | SSL via TOP1 | 3 | ||||||||
| apatinib, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | TOP1 | SSL via TOP1 | 2 | ||||||||
| biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging | ACE2 | SSL via ACE2 | 2 | ||||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | TOP1 | SSL via TOP1 | 2 | ||||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | TOP1 | SSL via TOP1 | 2 | ||||||||
| irinotecan, capecitabine | TOP1 | SSL via TOP1 | 2 | ||||||||
| irinotecan, docetaxel | TOP1 | SSL via TOP1 | 2 | ||||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | TOP1 | SSL via TOP1 | 2 | ||||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| rubitecan | TOP1 | SSL via TOP1 | 2 | ||||||||
| sacituzumab govitecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| topotecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| trastuzumab deruxtecan | TOP1 | SSL via TOP1 | yes | 2 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy (imrt), temozolomide, chloroquine, tumor treating fields therapy (ttf) | ACE2 | SSL via ACE2 | 1 | ||||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | TOP1 | SSL via TOP1 | 1 | ||||||||
| afatinib, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| aldoxorubicin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| amrubicin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| at-101, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avastin, temozolomide, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avastin, temozolomide, radiation therapy (xrt), irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| avelumab, irinotecan, paclitaxel, best supportive care (bsc) | TOP1 | SSL via TOP1 | 1 | ||||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | TOP1 | SSL via TOP1 | 1 | ||||||||
| azenosertib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, multigated acquisition scan, trastuzumab deruxtecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | TOP1 | SSL via TOP1 | 1 | ||||||||
| bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| berzosertib, sacituzumab govitecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab [avastin], irinotecan, temozolomide | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| bevacizumab, temozolomide, radiation therapy (xrt), topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bi 764532, topotecan, single agent chemotherapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| binimetinib, hydroxychloroquine | ACE2 | SSL via ACE2 | 1 | ||||||||
| biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin | TOP1 | SSL via TOP1 | 1 | ||||||||
| biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab | TOP1 | SSL via TOP1 | 1 | ||||||||
| biospecimen collection, lidocaine, resection | ORM2 | SSL via ORM2 | 1 | ||||||||
| bl-b01d1, irinotecan, paclitaxel, docetaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| bl-b01d1, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| bortezomib, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| camrelizumab, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib | TOP1 | SSL via TOP1 | 1 | ||||||||
| capecitabine, oxaliplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| carboplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study | TOP1 | SSL via TOP1 | 1 | ||||||||
| cetuximab, bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| cetuximab, irinotecan, oxaliplatin, uft | TOP1 | SSL via TOP1 | 1 | ||||||||
| chloroquine | ACE2 | SSL via ACE2 | 1 | ||||||||
| chloroquine, radiotherapy, temozolomide | ACE2 | SSL via ACE2 | 1 | ||||||||
| cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, gleevec™, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| cisplatin, irinotecan, capecitabine | TOP1 | SSL via TOP1 | 1 | ||||||||
| cobimetinib, hydroxychloroquine, atezolizumab | ACE2 | SSL via ACE2 | 1 | ||||||||
| digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| doxorubicin, cisplatin, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf | TOP1 | SSL via TOP1 | 1 | ||||||||
| edotecarin, temozolomide, carmustine (bcnu), lomustine (ccnu) | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil (5-fu), capecitabine, durvalumab, oxaliplatin, trastuzumab, trastuzumab deruxtecan, cisplatin, pembrolizumab, volrustomig, rilvegostomig | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration | TOP1 | SSL via TOP1 | 1 | ||||||||
| fluorouracil, oxaliplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| gemcitabine, abraxane, hydroxychloroquine | ACE2 | SSL via ACE2 | 1 | ||||||||
| gemcitabine, hydroxychloroquine, nab-paclitaxel, paricalcitol | ACE2 | SSL via ACE2 | 1 | ||||||||
| gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) | TOP1 | SSL via TOP1 | 1 | ||||||||
| gemcitabine, taxotere, xeloda, cisplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| hydroxychloroquine, gemcitabine | ACE2 | SSL via ACE2 | 1 | ||||||||
| hydroxychloroquine, radiotherapy | ACE2 | SSL via ACE2 | 1 | ||||||||
| hydroxychloroquine, temozolomide, pharmacological study, radiation | ACE2 | SSL via ACE2 | 1 | ||||||||
| ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| imatinib, irinotecan, carboplatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan hydrochloride liposome injection, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, 5-fluorouracil, leucovorin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, bevacizumab, fdopa-pet/mri imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab, radiation | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, carboplatin, bevacizumab, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, cisplatin, simvastatin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, ibi343, paclitaxel | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, leucovorin, 5-fluorouracil, docetaxel, cisplatin, leucovorin, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, lurbinectedin, irinotecan, topotecan, lurbinectedin | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, radiation therapy | TOP1 | SSL via TOP1 | 1 | ||||||||
| irinotecan, ramucirumab, blood for angiome profiling, blood for cfdna | TOP1 | SSL via TOP1 | 1 | ||||||||
| kc1036, irinotecan, docetaxel, s-1 | TOP1 | SSL via TOP1 | 1 | ||||||||
| liposomal irinotecan, 5-fu, lv, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| ljm716, byl719, paclitaxel, docetaxel, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| lurbinectedin, irinotecan, lurbinectedin, topotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| ly3962673, cetuximab, gemcitabine, nab-paclitaxel, oxaliplatin, leucovorin, irinotecan, 5-fluorouracil | TOP1 | SSL via TOP1 | 1 | ||||||||
| mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| mri-guided laser heat ablation (mla), doxorubicin, blood draw - dendritic cells, dynamic susceptibility contrast magnetic resonance imaging | TOP1 | SSL via TOP1 | 1 | ||||||||
| nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan, nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan | TOP1 | SSL via TOP1 | 1 | ||||||||
| nab-paclitaxel, gemcitabine, cisplatin, irinotecan, capecitabine, pembrolizumab, olaparib | TOP1 | SSL via TOP1 | 1 |