Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 58 of 58 matching drugs for PIK3CG — including drugs targeting any of its 38 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CG Direct 3
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CG Direct 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CG Direct 1
duvelisib PIK3CG Direct yes 0
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab DDR2 SSL via DDR2 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) DDR2 SSL via DDR2 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib CSK SSL via CSK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib PIK3CD SSL via PIK3CD 3
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment CSK SSL via CSK 2
regorafenib DDR2 SSL via DDR2 yes 2
regorafenib, laboratory biomarker analysis DDR2 SSL via DDR2 2
afatinib, dasatinib, palbociclib, everolimus, olaparib CSK SSL via CSK 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab NOS2 SSL via NOS2 1
bevacizumab, dasatinib, placebo CSK SSL via CSK 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging PIK3CD SSL via PIK3CD 1
biopsy, biospecimen collection, copanlisib, radiologic examination PIK3CD SSL via PIK3CD 1
bosutinib CAMK2G SSL via CAMK2G 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin PRKAA1 SSL via PRKAA1 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride CSK SSL via CSK 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method CSK SSL via CSK 1
dasatinib, laboratory biomarker analysis, physiologic testing CSK SSL via CSK 1
dasatinib, mfolfox6 CSK SSL via CSK 1
dasatinib, pharmacological study CSK SSL via CSK 1
dasatinib, temozolomide, placebo, radiation therapy CSK SSL via CSK 1
dexamethasone NOS2 SSL via NOS2 1
dexamethasone, fluorouracil, brachytherapy, phosphorus p32, radiation therapy NOS2 SSL via NOS2 1
dexamethasone, ondansetron, quality-of-life assessment NOS2 SSL via NOS2 1
disulfiram, copper, alkylating agents GPI SSL via GPI 1
docetaxel, 5-fu, radiotherapy, esophagectomy, dexamethasone NOS2 SSL via NOS2 1
gemcitabine, oxaliplatin, dexamethasone, floxuridine (fudr), implanted medical device NOS2 SSL via NOS2 1
gemcitabine, oxaliplatin, imatinib DDR2 SSL via DDR2 1
imatinib, irinotecan, carboplatin DDR2 SSL via DDR2 1
lutetium lu 177 dotatate, capecitabine, temozolomide, quality-of-life assessment, questionnaire administration SSTR5 SSL via SSTR5 1
minocycline, placebo, questionnaires NOS2 SSL via NOS2 1
pegph20, nab-paclitaxel, gemcitabine, dexamethasone, enoxaparin NOS2 SSL via NOS2 1
regorafenib, lomustine DDR2 SSL via DDR2 1
regorafenib, nivolumab, capeox, folfox regimen DDR2 SSL via DDR2 1
regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil DDR2 SSL via DDR2 1
regorafenib, temozolomide DDR2 SSL via DDR2 1
ryz101, everolimus, sunitinib, octreotide, lanreotide SSTR5 SSL via SSTR5 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide SSTR5 SSL via SSTR5 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin NOS2 SSL via NOS2 1
temozolomide, lomustine, regorafenib, radiation, paxalisib, val-083, vt1021, troriluzole, adi-peg 20 DDR2 SSL via DDR2 1
copanlisib PIK3CD SSL via PIK3CD yes 0
copanlisib hydrochloride PIK3CD SSL via PIK3CD yes 0
duvelisib PIK3CD SSL via PIK3CD yes 0
idelalisib PIK3CD SSL via PIK3CD yes 0
lanreotide SSTR5 SSL via SSTR5 yes 0
lanreotide acetate SSTR5 SSL via SSTR5 yes 0
lemborexant HCRTR1 SSL via HCRTR1 yes 0
octreotide SSTR5 SSL via SSTR5 yes 0
octreotide acetate SSTR5 SSL via SSTR5 yes 0
pasireotide SSTR5 SSL via SSTR5 yes 0
pasireotide diaspartate SSTR5 SSL via SSTR5 yes 0
pasireotide pamoate SSTR5 SSL via SSTR5 yes 0
suvorexant HCRTR1 SSL via HCRTR1 yes 0
umbralisib PIK3CD SSL via PIK3CD yes 0
umbralisib tosylate PIK3CD SSL via PIK3CD yes 0
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.