Drug × Cancer matrix

Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Clear
Showing 100 of 240 matching drugs for ARID1A — including drugs targeting any of its 55 synthetic-lethal partners , sorted by total cancer coverage.
Drug Target Relationship GBM LUAD SCLC LUSC OAC OSCC PDAC Reposition #cancers
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib ERBB2 SSL via ERBB2 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib SMO SSL via SMO 3
afatinib ERBB2 SSL via ERBB2 yes 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan TOP1 SSL via TOP1 3
lurbinectedin, irinotecan TOP1 SSL via TOP1 3
mrtx849, pembrolizumab, cetuximab, afatinib ERBB2 SSL via ERBB2 3
trastuzumab emtansine ERBB2 SSL via ERBB2 yes 3
tucatinib ERBB2 SSL via ERBB2 yes 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel ERBB2 SSL via ERBB2 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel IGF1R SSL via IGF1R 2
apatinib, irinotecan TOP1 SSL via TOP1 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan TOP1 SSL via TOP1 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine TOP1 SSL via TOP1 2
cetuximab, cisplatin, irinotecan, radiation therapy, surgery TOP1 SSL via TOP1 2
cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study IGF1R SSL via IGF1R 2
cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study IGF1R SSL via IGF1R 2
eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab ERBB2 SSL via ERBB2 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib ERBB2 SSL via ERBB2 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide TOP1 SSL via TOP1 2
irinotecan, capecitabine TOP1 SSL via TOP1 2
irinotecan, docetaxel TOP1 SSL via TOP1 2
lapatinib ERBB2 SSL via ERBB2 yes 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab TOP1 SSL via TOP1 2
motexafin gadolinium, radiation therapy RRM2 SSL via RRM2 2
pembrolizumab, paclitaxel, docetaxel, irinotecan TOP1 SSL via TOP1 2
pembrolizumab, sonidegib SMO SSL via SMO 2
radiotherapy targeted to the primary lesion, radiotherapy targeted to the metastatic lesions, anti-pd-1 monoclonal antibody, trastuzumab, chemotherapy, r0 total/subtotal gastrectomy with d2 lymphadenectomy, metastasectomy, local ablative therapies ERBB2 SSL via ERBB2 2
rubitecan TOP1 SSL via TOP1 2
sacituzumab govitecan TOP1 SSL via TOP1 yes 2
topotecan TOP1 SSL via TOP1 yes 2
trastuzumab ERBB2 SSL via ERBB2 yes 2
trastuzumab deruxtecan TOP1 SSL via TOP1 yes 2
trastuzumab, abt-806, bemarituzumab, ramucirumab, nivolumab, standard cytotherapy ERBB2 SSL via ERBB2 2
trastuzumab, tipifarnib ERBB2 SSL via ERBB2 2
2b3-101, trastuzumab, 2b3-101 60 mg/m2 every 4 weeks, 2b3-101 50 mg/m2 every 3 weeks ERBB2 SSL via ERBB2 1
3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide RRM2 SSL via RRM2 1
5 fluorouracil, leucovorin, irinotecan, oxaliplatin TOP1 SSL via TOP1 1
5-fu, leucovorin, docetaxel, oxaliplatin (flot), trastuzumab, post-operative treatment trastuzumab mono therapy ERBB2 SSL via ERBB2 1
9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan TOP1 SSL via TOP1 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf TOP1 SSL via TOP1 1
afatinib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging ERBB2 SSL via ERBB2 1
afatinib, dasatinib, palbociclib, everolimus, olaparib ERBB2 SSL via ERBB2 1
afatinib, docetaxel, radiation therapy ERBB2 SSL via ERBB2 1
afatinib, gefitinib ERBB2 SSL via ERBB2 1
afatinib, irinotecan ERBB2 SSL via ERBB2 1
afatinib, irinotecan TOP1 SSL via TOP1 1
aldoxorubicin, topotecan TOP1 SSL via TOP1 1
amrubicin, topotecan TOP1 SSL via TOP1 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel TOP1 SSL via TOP1 1
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib SMO SSL via SMO 1
at-101, topotecan TOP1 SSL via TOP1 1
avastin, temozolomide, irinotecan TOP1 SSL via TOP1 1
avastin, temozolomide, radiation therapy (xrt), irinotecan TOP1 SSL via TOP1 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) TOP1 SSL via TOP1 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine TOP1 SSL via TOP1 1
azenosertib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, multigated acquisition scan, trastuzumab deruxtecan TOP1 SSL via TOP1 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 TOP1 SSL via TOP1 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil TOP1 SSL via TOP1 1
berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging TOP1 SSL via TOP1 1
berzosertib, sacituzumab govitecan TOP1 SSL via TOP1 1
bevacizumab [avastin], irinotecan, temozolomide TOP1 SSL via TOP1 1
bevacizumab, irinotecan TOP1 SSL via TOP1 1
bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging TOP1 SSL via TOP1 1
bevacizumab, temozolomide, radiation therapy (xrt), topotecan TOP1 SSL via TOP1 1
bi 764532, topotecan, single agent chemotherapy TOP1 SSL via TOP1 1
biopsy, biospecimen collection, ceralasertib, computed tomography, echocardiography, multigated acquisition scan, positron emission tomography, trastuzumab deruxtecan TOP1 SSL via TOP1 1
biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin TOP1 SSL via TOP1 1
biopsy, biospecimen collection, echocardiography, pertuzumab, radiologic examination, trastuzumab ERBB2 SSL via ERBB2 1
biopsy, biospecimen collection, echocardiography, radionuclide imaging, vismodegib SMO SSL via SMO 1
biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab TOP1 SSL via TOP1 1
bl-b01d1, irinotecan, paclitaxel, docetaxel TOP1 SSL via TOP1 1
bl-b01d1, topotecan TOP1 SSL via TOP1 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan TOP1 SSL via TOP1 1
bortezomib, irinotecan TOP1 SSL via TOP1 1
camrelizumab, docetaxel, irinotecan TOP1 SSL via TOP1 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib TOP1 SSL via TOP1 1
capecitabine, medi4736 (durvalumab), trastuzumab, rucaparib, ramucirumab ERBB2 SSL via ERBB2 1
capecitabine, oxaliplatin, irinotecan TOP1 SSL via TOP1 1
carboplatin, irinotecan TOP1 SSL via TOP1 1
carboplatin, laboratory biomarker analysis, paclitaxel, quality-of-life assessment, radiation therapy, therapeutic conventional surgery, trastuzumab ERBB2 SSL via ERBB2 1
carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study TOP1 SSL via TOP1 1
cetuximab, bevacizumab, irinotecan TOP1 SSL via TOP1 1
cetuximab, irinotecan, oxaliplatin, uft TOP1 SSL via TOP1 1
cetuximab, trastuzumab ERBB2 SSL via ERBB2 1
chemotherapy, cladribine, radiation therapy RRM2 SSL via RRM2 1
chemotherapy, disulfiram, gemcitabine hydrochloride, laboratory biomarker analysis ALDH2 SSL via ALDH2 1
cisplatin, 5-fluorouracil or capecitabine, trastuzumab, pertuzumab, gastrectomy ERBB2 SSL via ERBB2 1
cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy TOP1 SSL via TOP1 1
cisplatin, gleevec™, irinotecan TOP1 SSL via TOP1 1
cisplatin, irinotecan, capecitabine TOP1 SSL via TOP1 1
conventional surgery, 3-dimensional conformal radiation therapy, stereotactic radiosurgery, motexafin gadolinium, magnetic resonance imaging, spectroscopy RRM2 SSL via RRM2 1
db-1310, trastuzumab, osimertinib ERBB2 SSL via ERBB2 1
diagnostic laboratory biomarker analysis, erlotinib hydrochloride, gemcitabine hydrochloride, vismodegib SMO SSL via SMO 1
digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin TOP1 SSL via TOP1 1
disitamab vedotin, tucatinib ERBB2 SSL via ERBB2 1
disulfiram, copper gluconate, surgery, radiation, temozolomide ALDH2 SSL via ALDH2 1
disulfiram, copper, alkylating agents ALDH2 SSL via ALDH2 1
disulfiram, copper, alkylating agents IGFALS SSL via IGFALS 1
docetaxel, leucovorin, fluorouracil, cisplatin, docetaxel, cisplatin, fluorouracil, neulasta, or neupogen, docetaxel, leukvorin, flurouracil, cisplatin, trastuzumab ERBB2 SSL via ERBB2 1
docetaxel, oxaliplatin, capecitabine, trastuzumab ERBB2 SSL via ERBB2 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable list from cansar.ai.